Complement component 1s

C1S
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ELV, 1NZI, 4J1Y, 4LMF, 4LOR, 4LOS, 4LOT
Identifiers
Aliases	C1S , EDSPD2, complement C1s
External IDs	OMIM: 120580; MGI: 3644269; HomoloGene: 1314; GeneCards: C1S; OMA:C1S - orthologs
EC number	3.4.21.42
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.31 Start 6,988,259 bp [1] End 7,071,032 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F2 Start 124,601,584 bp [2] End 124,613,044 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium right lobe of liver parietal pleura right ovary gallbladder left ovary gastric mucosa tibial nerve left uterine tube synovial joint Top expressed in muscle of thigh morula embryo white adipose tissue bone marrow adrenal gland urinary bladder ovary lens islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding peptidase activity serine-type peptidase activity protein binding hydrolase activity metal ion binding identical protein binding serine-type endopeptidase activity Cellular component blood microparticle extracellular exosome extracellular region extracellular space Biological process proteolysis complement activation, classical pathway immune system process innate immune response complement activation, lectin pathway complement activation regulation of complement activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 716 317677 Ensembl ENSG00000182326 ENSMUSG00000079343 UniProt P09871 Q8CFG8 RefSeq (mRNA) NM_001734 NM_201442 NM_001346850 NM_173864 RefSeq (protein) NP_001333779 NP_001725 NP_958850 NP_776289 Location (UCSC) Chr 12: 6.99 – 7.07 Mb Chr 6: 124.6 – 124.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Complement component 1s (EC 3.4.21.42, C1 esterase , activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system. C1s is part of the C1 complex. ^{[5] [6] [7] [8]} In humans, it is encoded by the C1S gene. ^[9]

C1s cleaves C4 and C2, which eventually leads to the production of the classical pathway C3-convertase.

Classical pathway. (Some labels are in Polish.)

See also

• C1q - another part of the C1 complex
• C1r - another part of the C1 complex
• MASP-2 - a protein similar to C1s, part of the lectin pathway

References

1. GRCh38: Ensembl release 89: ENSG00000182326 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079343 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sim RB (1981). "The human complement system serine proteases and their proenzymes". Proteolytic Enzymes, Part C. Methods in Enzymology. Vol. 80 Pt C. pp. 26–42. doi:10.1016/s0076-6879(81)80006-7. ISBN   9780121819804. PMID   6281620.
6. Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (December 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". European Journal of Biochemistry. 169 (3): 547–53. doi: 10.1111/j.1432-1033.1987.tb13644.x . PMID   3500856.
7. Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system". Annual Review of Biochemistry. 57: 321–47. doi:10.1146/annurev.bi.57.070188.001541. PMID   3052276.
8. Skoog MT, Mehdi S, Wiseman JS, Bey P (June 1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 996 (1–2): 89–94. doi:10.1016/0167-4838(89)90099-x. PMID   2500154.
9. "Entrez Gene: C1S Complement component 1, s subcomponent".

Further reading

• Luo C, Thielens NM, Gagnon J, Gal P, Sarvari M, Tseng Y, Tosi M, Zavodszky P, Arlaud GJ, Schumaker VN (May 1992). "Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex". Biochemistry. 31 (17): 4254–62. doi:10.1021/bi00132a015. PMID   1533159.
• Illy C, Thielens NM, Gagnon J, Arlaud GJ (July 1991). "Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites". Biochemistry. 30 (29): 7135–41. doi:10.1021/bi00243a014. PMID   1854725.
• Hess D, Schaller J, Rickli EE (March 1991). "Identification of the disulfide bonds of human complement C1s". Biochemistry. 30 (11): 2827–33. doi:10.1021/bi00225a014. PMID   2007122.
• Thielens NM, Van Dorsselaer A, Gagnon J, Arlaud GJ (April 1990). "Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region". Biochemistry. 29 (14): 3570–8. doi:10.1021/bi00466a021. PMID   2141278.
• Busby TF, Ingham KC (May 1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q". Biochemistry. 29 (19): 4613–8. doi:10.1021/bi00471a016. PMID   2372546.
• Kusumoto H, Hirosawa S, Salier JP, Hagen FS, Kurachi K (October 1988). "Human genes for complement components C1r and C1s in a close tail-to-tail arrangement". Proceedings of the National Academy of Sciences of the United States of America. 85 (19): 7307–11. Bibcode:1988PNAS...85.7307K. doi: 10.1073/pnas.85.19.7307 . PMC   282175 . PMID   2459702.
• Katz Y, Strunk RC (March 1989). "Synthesis and regulation of C1 inhibitor in human skin fibroblasts". Journal of Immunology. 142 (6): 2041–5. doi: 10.4049/jimmunol.142.6.2041 . PMID   2537870.
• Tosi M, Duponchel C, Meo T, Couture-Tosi E (August 1989). "Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin". Journal of Molecular Biology. 208 (4): 709–14. doi:10.1016/0022-2836(89)90161-7. PMID   2553984.
• Tosi M, Duponchel C, Meo T, Julier C (December 1987). "Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr". Biochemistry. 26 (26): 8516–24. doi:10.1021/bi00400a004. PMID   2831944.
• Nguyen VC, Tosi M, Gross MS, Cohen-Haguenauer O, Jegou-Foubert C, de Tand MF, Meo T, Frézal J (April 1988). "Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13". Human Genetics. 78 (4): 363–8. doi:10.1007/BF00291737. PMID   2834284. S2CID   30582112.
• Spycher SE, Nick H, Rickli EE (April 1986). "Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation". European Journal of Biochemistry. 156 (1): 49–57. doi: 10.1111/j.1432-1033.1986.tb09546.x . PMID   3007145.
• Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (December 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". European Journal of Biochemistry. 169 (3): 547–53. doi: 10.1111/j.1432-1033.1987.tb13644.x . PMID   3500856.
• Kauffman D, Hofmann T, Bennick A, Keller P (May 1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry. 25 (9): 2387–92. doi:10.1021/bi00357a013. PMID   3521730.
• Bock SC, Skriver K, Nielsen E, Thøgersen HC, Wiman B, Donaldson VH, Eddy RL, Marrinan J, Radziejewska E, Huber R (July 1986). "Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization". Biochemistry. 25 (15): 4292–301. doi:10.1021/bi00363a018. PMID   3756141.
• Carter PE, Dunbar B, Fothergill JE (December 1983). "The serine proteinase chain of human complement component C1s. Cyanogen bromide cleavage and N-terminal sequences of the fragments". The Biochemical Journal. 215 (3): 565–71. doi:10.1042/bj2150565. PMC   1152437 . PMID   6362661.
• Nilsson T, Sjöholm I, Wiman B (September 1983). "Structural and circular-dichroism studies on the interaction between human C1-esterase inhibitor and C1s". The Biochemical Journal. 213 (3): 617–24. doi:10.1042/bj2130617. PMC   1152176 . PMID   6604523.
• Rossi V, Gaboriaud C, Lacroix M, Ulrich J, Fontecilla-Camps JC, Gagnon J, Arlaud GJ (June 1995). "Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling". Biochemistry. 34 (22): 7311–21. doi:10.1021/bi00022a004. PMID   7779774.
• Bersch B, Hernandez JF, Marion D, Arlaud GJ (February 1998). "Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family". Biochemistry. 37 (5): 1204–14. doi:10.1021/bi971851v. PMID   9477945.
• Endo Y, Takahashi M, Nakao M, Saiga H, Sekine H, Matsushita M, Nonaka M, Fujita T (November 1998). "Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates". Journal of Immunology. 161 (9): 4924–30. doi: 10.4049/jimmunol.161.9.4924 . PMID   9794427.
• Inoue N, Saito T, Masuda R, Suzuki Y, Ohtomi M, Sakiyama H (October 1998). "Selective complement C1s deficiency caused by homozygous four-base deletion in the C1s gene". Human Genetics. 103 (4): 415–8. doi:10.1007/s004390050843. PMID   9856483. S2CID   7689382.

External links

• Complement+C1s at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human C1S genome location and C1S gene details page in the UCSC Genome Browser .