KLK9

KLK9
Identifiers
Aliases	KLK9 , KLK-L3, KLKL3, kallikrein related peptidase 9
External IDs	OMIM: 605504; MGI: 1921082; HomoloGene: 40832; GeneCards: KLK9; OMA:KLK9 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.41 Start 51,002,508 bp [1] End 51,009,634 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 B3|7 28.26 cM Start 43,441,315 bp [2] End 43,446,181 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen mucosa of esophagus tonsil vagina right uterine tube ectocervix minor salivary glands prefrontal cortex endometrium Top expressed in esophagus lip zone of skin embryo genital tubercle stomach tail of embryo urinary bladder placenta thymus More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region secretory granule Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284366 101533 Ensembl ENSG00000213022 ENSMUSG00000047884 UniProt Q9UKQ9 Q32M27 RefSeq (mRNA) NM_012315 NM_028660 RefSeq (protein) NP_036447 NP_082936 Location (UCSC) Chr 19: 51 – 51.01 Mb Chr 7: 43.44 – 43.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene. ^[5]

Function

KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. ^{[6] [7] [8]} KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin. ^[5]

Clinical significance

KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian ^[9] and breast cancer patients. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000213022 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047884 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yousef GM, Diamandis EP (April 2000). "The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9)". Genomics. 65 (2): 184–94. CiteSeerX   10.1.1.326.8491 . doi:10.1006/geno.2000.6159. PMID   10783266.
6. "Entrez Gene: KLK9".
7. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID   16800724. S2CID   436200.
8. Diamandis EP, Deperthes D, Lundwall Å (June 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biological Chemistry. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID   16800723. S2CID   83910246.
9. Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker". Cancer Research. 61 (21): 7811–8. PMID   11691797.
10. Yousef GM, Scorilas A, Nakamura T, Ellatif MA, Ponzone R, Biglia N, Maggiorotto F, Roagna R, Sismondi P, Diamandis EP (March 2003). "The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer". Breast Cancer Research and Treatment. 78 (2): 149–58. doi:10.1023/A:1022931403825. PMID   12725415. S2CID   6515644.

Further reading

• Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker". Cancer Research. 61 (21): 7811–8. PMID   11691797.
• Yousef GM, Luo LY, Diamandis EP (1999). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Research. 19 (4B): 2843–52. PMID   10652563.
• Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, Moss P, Paeper B, Wang K (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID   11054574.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.307 ^{[ permanent dead link ]}