KLK9

Last updated
KLK9
Identifiers
Aliases KLK9 , KLK-L3, KLKL3, kallikrein related peptidase 9
External IDs OMIM: 605504 MGI: 1921082 HomoloGene: 40832 GeneCards: KLK9
Gene location (Human)
Ideogram human chromosome 19.svg
Chr. Chromosome 19 (human) [1]
Human chromosome 19 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 19q13.41Start51,002,508 bp [1]
End51,009,634 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

284366

101533

Ensembl

ENSG00000213022

ENSMUSG00000047884

UniProt

Q9UKQ9

Q32M27

RefSeq (mRNA)

NM_012315

NM_028660

RefSeq (protein)

NP_036447

NP_082936

Location (UCSC) Chr 19: 51 – 51.01 Mb Chr 7: 43.79 – 43.8 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene. [5]

Contents

Function

KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. [6] [7] [8] KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin. [5]

Clinical significance

KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian [9] and breast cancer patients. [10]

Related Research Articles

Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (KLKB1) has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.

KLK1

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.

KLK2

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.

ST14

Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.

KLK6

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene.

KLK10

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.

KLK5

Kallikrein-related peptidase 5 (KLK5), formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

KLK4

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

KLK11

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

SERPINB6

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.

KLK7

Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).

KLK13

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.

KLK8

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.

KLK14

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.

KLK15

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.

KLK12

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.

BCL2L12

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14. SPINK6 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK9.

Stratum corneum chymotryptic enzyme is an enzyme. This enzyme catalyses the following chemical reaction

Kallikrein 8 is an enzyme. This enzyme catalyses the following chemical reaction

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000213022 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047884 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Yousef GM, Diamandis EP (April 2000). "The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9)". Genomics. 65 (2): 184–94. doi:10.1006/geno.2000.6159. PMID   10783266.
  6. ↑ "Entrez Gene: KLK9".
  7. ↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID   16800724. S2CID   436200.
  8. ↑ Diamandis EP, Deperthes D, Lundwall Å (June 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID   16800723. S2CID   83910246.
  9. ↑ Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker". Cancer Research. 61 (21): 7811–8. PMID   11691797.
  10. ↑ Yousef GM, Scorilas A, Nakamura T, Ellatif MA, Ponzone R, Biglia N, Maggiorotto F, Roagna R, Sismondi P, Diamandis EP (March 2003). "The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer". Breast Cancer Research and Treatment. 78 (2): 149–58. doi:10.1023/A:1022931403825. PMID   12725415. S2CID   6515644.

Further reading

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