KLK9 | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | KLK9 , KLK-L3, KLKL3, kallikrein related peptidase 9 | ||||||||||||||||||||||||
External IDs | OMIM: 605504 MGI: 1921082 HomoloGene: 40832 GeneCards: KLK9 | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||||||||||
RefSeq (protein) | |||||||||||||||||||||||||
Location (UCSC) | Chr 19: 51 – 51.01 Mb | Chr 7: 43.79 – 43.8 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene. [5]
KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. [6] [7] [8] KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin. [5]
KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian [9] and breast cancer patients. [10]
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (KLKB1) has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.
Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.
Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.
Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.
Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene.
Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.
Kallikrein-related peptidase 5 (KLK5), formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.
Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.
Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.
Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.
Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).
Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.
Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.
Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.
Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.
Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.
Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.
Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14. SPINK6 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK9.
Stratum corneum chymotryptic enzyme is an enzyme. This enzyme catalyses the following chemical reaction
Kallikrein 8 is an enzyme. This enzyme catalyses the following chemical reaction
This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it. |