KLK9

Last updated
KLK9
Identifiers
Aliases KLK9 , KLK-L3, KLKL3, kallikrein related peptidase 9
External IDs OMIM: 605504; MGI: 1921082; HomoloGene: 40832; GeneCards: KLK9; OMA:KLK9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

284366

101533

Ensembl

ENSG00000213022

ENSMUSG00000047884

UniProt

Q9UKQ9

Q32M27

RefSeq (mRNA)

NM_012315

NM_028660

RefSeq (protein)

NP_036447

NP_082936

Location (UCSC) Chr 19: 51 – 51.01 Mb Chr 7: 43.44 – 43.45 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene. [5]

Contents

Function

KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. [6] [7] [8] KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin. [5]

Clinical significance

KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian [9] and breast cancer patients. [10]

Related Research Articles

<span class="mw-page-title-main">Alpha 2-antiplasmin</span> Protein-coding gene in the species Homo sapiens

Alpha 2-antiplasmin is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.

Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.

<span class="mw-page-title-main">KLK1</span> Protein-coding gene in the species Homo sapiens

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.

<span class="mw-page-title-main">KLK2</span> Protein-coding gene in the species Homo sapiens

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.

<span class="mw-page-title-main">KLK6</span> Protein-coding gene in the species Homo sapiens

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene. Kallikrein-6 is also referred to as neurosin, protease M, hK6, or zyme. It is a 223 amino acid sequence, derived from its 244 original form, which contains a 16 residue presignal and 5 residue activation peptide.

<span class="mw-page-title-main">KLK10</span> Protein-coding gene in the species Homo sapiens

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.

<span class="mw-page-title-main">Kallikrein-5</span> Protein-coding gene in the species Homo sapiens

Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

<span class="mw-page-title-main">KLK4</span> Mammalian protein found in Homo sapiens

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

<span class="mw-page-title-main">KLK11</span> Protein-coding gene in the species Homo sapiens

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

<span class="mw-page-title-main">KLK7</span> Protein-coding gene in the species Homo sapiens

Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).

<span class="mw-page-title-main">VTCN1</span> Protein-coding gene in the species Homo sapiens

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.

<span class="mw-page-title-main">KLK13</span> Gene of the species Homo sapiens

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.

<span class="mw-page-title-main">KLK8</span> Protein-coding gene in the species Homo sapiens

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.

<span class="mw-page-title-main">KLK14</span> Protein-coding gene in the species Homo sapiens

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.

<span class="mw-page-title-main">KLK15</span> Protein-coding gene in the species Homo sapiens

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.

<span class="mw-page-title-main">KLK12</span> Protein-coding gene in the species Homo sapiens

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.

<span class="mw-page-title-main">SIGLEC9</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.

<span class="mw-page-title-main">BCL2L12</span> Protein-coding gene in the species Homo sapiens

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

Stratum corneum chymotryptic enzyme is an enzyme. This enzyme catalyses the following chemical reaction

Judith Ann Clements is an Australian academic and educator, specializing in Kallikrein proteases in prostate and ovarian cancers. Clements is the scientific director at the Australian Prostate Cancer Research Centre – Queensland and was head of the Cancer Research Program at the Institute of Health and Biomedical Innovation (IHBI) of Queensland University of Technology at the Translational Research Institute (Australia) from 1997–2014. Her biography was published in the Cancer and Metastasis Reviews in 2019

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000213022 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047884 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Yousef GM, Diamandis EP (April 2000). "The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9)". Genomics. 65 (2): 184–94. CiteSeerX   10.1.1.326.8491 . doi:10.1006/geno.2000.6159. PMID   10783266.
  6. ↑ "Entrez Gene: KLK9".
  7. ↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID   16800724. S2CID   436200.
  8. ↑ Diamandis EP, Deperthes D, Lundwall Å (June 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biological Chemistry. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID   16800723. S2CID   83910246.
  9. ↑ Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker". Cancer Research. 61 (21): 7811–8. PMID   11691797.
  10. ↑ Yousef GM, Scorilas A, Nakamura T, Ellatif MA, Ponzone R, Biglia N, Maggiorotto F, Roagna R, Sismondi P, Diamandis EP (March 2003). "The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer". Breast Cancer Research and Treatment. 78 (2): 149–58. doi:10.1023/A:1022931403825. PMID   12725415. S2CID   6515644.

Further reading


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