PRSS8

Last updated
PRSS8
Protein PRSS8 PDB 3DFJ.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRSS8 , CAP1, PROSTASIN, protease, serine 8, serine protease 8
External IDs OMIM: 600823 MGI: 1923810 HomoloGene: 20613 GeneCards: PRSS8
Orthologs
SpeciesHumanMouse
Entrez

5652

76560

Ensembl

ENSG00000052344

ENSMUSG00000030800

UniProt

Q16651

Q9ESD1

RefSeq (mRNA)

NM_002773

NM_133351

RefSeq (protein)

NP_002764

n/a

Location (UCSC) Chr 16: 31.13 – 31.14 Mb Chr 7: 127.52 – 127.53 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prostasin is a protein that in humans is encoded by the PRSS8 gene. [5] [6] [7]

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

The protein is implicated in epithelial sodium channel regulation [8] and may help regulate a variety of tissue functions that involve a sodium channel. [9]

High prostasin plasma levels may be associated with a higher risk for diabetes and death from cancer, especially in people with high blood sugar. [10] [ unreliable medical source ]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000052344 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030800 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Yu JX, Chao L, Ward DC, Chao J (Mar 1996). "Structure and chromosomal localization of the human prostasin (PRSS8) gene". Genomics. 32 (3): 334–40. doi: 10.1006/geno.1996.0127 . PMID   8838796.
  6. ↑ Yu JX, Chao L, Chao J (Jun 1995). "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA". The Journal of Biological Chemistry. 270 (22): 13483–9. doi: 10.1074/jbc.270.22.13483 . PMID   7768952.
  7. ↑ "Entrez Gene: PRSS8 protease, serine, 8".
  8. ↑ Koda A, Wakida N, Toriyama K, Yamamoto K, Iijima H, Tomita K, Kitamura K (Apr 2009). "Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity". Hypertension Research. 32 (4): 276–81. doi: 10.1038/hr.2009.6 . PMID   19262497.
  9. ↑ Zhu H, Guo D, Li K, Yan W, Tan Y, Wang X, Treiber FA, Chao J, Snieder H, Dong Y (Sep 2008). "Prostasin: a possible candidate gene for human hypertension". American Journal of Hypertension. 21 (9): 1028–33. doi:10.1038/ajh.2008.224. PMC   3812941 . PMID   18583984.
  10. ↑ Bao X, Xu B, Muhammad IF, Nilsson PM, Nilsson J, Engström G (August 2022). "Plasma prostasin: a novel risk marker for incidence of diabetes and cancer mortality". Diabetologia. 65 (10): 1642–1651. doi:10.1007/s00125-022-05771-w. PMC   9477896 . PMID   35922613.

Further reading

Chen LM, Hatfield ML, Fu YY, Chai KX. Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells. Prostate. 2009 Dec 1;69(16):1790-801. doi: 10.1002/pros.21030. PMID: 19670249.


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