METAP1

METAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B3H, 2B3K, 2B3L, 2G6P, 2GZ5, 2NQ6, 2NQ7, 4FLI, 4FLJ, 4FLK, 4FLL, 4HXX, 4IKR, 4IKS, 4IKT, 4IKU, 4IU6, 4U1B, 4U69, 4U6C, 4U6E, 4U6J, 4U6W, 4U6Z, 4U70, 4U71, 4U73, 4U75, 4U76
Identifiers
Aliases	METAP1 , MAP1A, MetAP1A, methionyl aminopeptidase 1
External IDs	OMIM: 610151; MGI: 1922874; HomoloGene: 6488; GeneCards: METAP1; OMA:METAP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q23 Start 98,995,620 bp [1] End 99,062,813 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G3 Start 138,164,717 bp [2] End 138,195,276 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis endometrium Descending thoracic aorta epithelium of nasopharynx rectum urinary bladder gingival epithelium hair follicle oral cavity Top expressed in primitive streak lens vastus lateralis muscle triceps brachii muscle sternocleidomastoid muscle temporal muscle hair follicle crypt of lieberkuhn of small intestine digastric muscle ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity aminopeptidase activity metalloexopeptidase activity hydrolase activity metal ion binding Cellular component cytosol cytoplasm Biological process peptidyl-methionine modification platelet aggregation N-terminal protein amino acid modification regulation of translation proteolysis regulation of rhodopsin mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23173 75624 Ensembl ENSG00000164024 ENSMUSG00000005813 UniProt P53582 Q8BP48 RefSeq (mRNA) NM_015143 NM_175224 RefSeq (protein) NP_055958 NP_780433 Location (UCSC) Chr 4: 99 – 99.06 Mb Chr 3: 138.16 – 138.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000164024 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005813 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID   7788527.
6. Dummitt B, Fei Y, Chang YH (Jul 2002). "Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae". Protein Pept Lett. 9 (4): 295–303. doi:10.2174/0929866023408607. PMID   12144506.
7. "Entrez Gene: METAP1 methionyl aminopeptidase 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Serero A, Giglione C, Sardini A, et al. (2004). "An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway". J. Biol. Chem. 278 (52): 52953–63. doi: 10.1074/jbc.M309770200 . PMID   14532271.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Addlagatta A, Hu X, Liu JO, Matthews BW (2006). "Structural basis for the functional differences between type I and type II human methionine aminopeptidases". Biochemistry. 44 (45): 14741–9. doi:10.1021/bi051691k. PMID   16274222.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Selvakumar P, Lakshmikuttyamma A, Dimmock JR, Sharma RK (2006). "Methionine aminopeptidase 2 and cancer". Biochim. Biophys. Acta. 1765 (2): 148–54. doi:10.1016/j.bbcan.2005.11.001. PMID   16386852.
• Hu X, Addlagatta A, Lu J, et al. (2007). "Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression". Proc. Natl. Acad. Sci. U.S.A. 103 (48): 18148–53. doi: 10.1073/pnas.0608389103 . PMC   1838721 . PMID   17114291.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Methionine aminopeptidase 1