KLK11

KLK11
Identifiers
Aliases	KLK11 , PRSS20, TLSP, kallikrein related peptidase 11
External IDs	OMIM: 604434; MGI: 1929977; HomoloGene: 27048; GeneCards: KLK11; OMA:KLK11 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.41 Start 51,022,216 bp [1] End 51,028,039 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B3 Start 43,424,028 bp [2] End 43,428,687 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium skin of abdomen skin of arm skin of leg human penis oral cavity mucosa of pharynx vulva cervix epithelium gallbladder Top expressed in lip esophagus skin of external ear embryo skin of back embryo genital tubercle umbilical cord skin of abdomen trachea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region Golgi apparatus extracellular exosome extracellular space secretory granule Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11012 56538 Ensembl ENSG00000167757 ENSMUSG00000067616 UniProt Q9UBX7 Q9QYN3 RefSeq (mRNA) NM_001136032 NM_001167605 NM_006853 NM_144947 NM_001177373 NM_019974 RefSeq (protein) NP_001129504 NP_001161077 NP_006844 NP_659196 NP_001170844 NP_064358 Location (UCSC) Chr 19: 51.02 – 51.03 Mb Chr 7: 43.42 – 43.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene. ^{[5] [6] [7] [8] [9]}

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000167757 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067616 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta. 1399 (2–3): 225–8. doi:10.1016/s0167-4781(98)00116-x. PMID   9765601.
6. Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID   10662548.
7. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID   16800724. S2CID   436200.
8. Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID   16800723. S2CID   83910246.
9. "Entrez Gene: KLK11 kallikrein-related peptidase 11".

Further reading

• Mitsui S, Yamada T, Okui A, et al. (2000). "A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate". Biochem. Biophys. Res. Commun. 272 (1): 205–11. doi:10.1006/bbrc.2000.2761. PMID   10872828.
• Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID   11054574.
• Nakamura T, Mitsui S, Okui A, et al. (2002). "Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines". Prostate. 49 (1): 72–8. doi:10.1002/pros.1119. PMID   11550212. S2CID   21572408.
• Diamandis EP, Okui A, Mitsui S, et al. (2002). "Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma". Cancer Res. 62 (1): 295–300. PMID   11782391.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nakamura T, Mitsui S, Okui A, et al. (2003). "Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate". Prostate. 54 (4): 299–305. doi:10.1002/pros.10191. PMID   12539228. S2CID   21482369.
• Nakamura T, Stephan C, Scorilas A, et al. (2003). "Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues". Urology. 61 (5): 1042–6. doi:10.1016/S0090-4295(02)02443-3. PMID   12736044.
• Borgoño CA, Fracchioli S, Yousef GM, et al. (2003). "Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma". Int. J. Cancer. 106 (4): 605–10. CiteSeerX   10.1.1.623.9575 . doi:10.1002/ijc.11296. PMID   12845660. S2CID   13671141.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Shigemasa K, Gu L, Tanimoto H, et al. (2004). "Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer". Clin. Cancer Res. 10 (8): 2766–70. doi:10.1158/1078-0432.CCR-03-0269. PMID   15102682. S2CID   1192794.
• Diamandis EP, Borgoño CA, Scorilas A, et al. (2005). "Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients". Clin. Biochem. 37 (9): 823–9. doi:10.1016/j.clinbiochem.2004.04.009. PMID   15329323.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stavropoulou P, Gregorakis AK, Plebani M, Scorilas A (2005). "Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer". Clin. Chim. Acta. 357 (2): 190–5. doi:10.1016/j.cccn.2005.03.026. PMID   15893744.
• Planque C, Aïnciburu M, Heuzé-Vourc'h N, et al. (2006). "Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues". Biol. Chem. 387 (6): 783–8. doi:10.1515/BC.2006.098. PMID   16800740. S2CID   6937753.
• Mitsui S, Nakamura T, Okui A, et al. (2006). "Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin". FEBS J. 273 (16): 3678–86. doi:10.1111/j.1742-4658.2006.05372.x. PMID   16911518. S2CID   25021929.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.257 ^{[ permanent dead link ]}