KLK2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | KLK2 , KLK2A2, hGK-1, hK2, kallikrein related peptidase 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 147960 HomoloGene: 124422 GeneCards: KLK2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue. [3] [4] [5] [6]
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.
CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family.
Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.
Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.
C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.
G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.
Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene. Kallikrein-6 is also referred to as neurosin, protease M, hK6, or zyme. It is a 223 amino acid sequence, derived from its 244 original form, which contains a 16 residue presignal and 5 residue activation peptide.
Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.
Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.
Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.
Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.
Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.
Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.
Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).
Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.
Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.
Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.
Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.
Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.
Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.
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