KLK1

KLK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SPJ
Identifiers
Aliases	KLK1 , KLKR, Klk6, hK1, kallikrein 1
External IDs	OMIM: 147910; MGI: 102850; HomoloGene: 110727; GeneCards: KLK1; OMA:KLK1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.33 Start 50,819,146 bp [1] End 50,823,787 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 B3|7 28.74 cM Start 43,874,784 bp [2] End 43,879,042 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas mucosa of transverse colon parotid gland rectum skin of abdomen islet of Langerhans skin of leg beta cell skin of arm gonad Top expressed in submandibular gland parotid gland right kidney left colon human kidney pyloric antrum lacrimal gland crypt of lieberkuhn of small intestine duodenum islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component extracellular exosome nucleus secretory granule Biological process proteolysis regulation of systemic arterial blood pressure zymogen activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3816 16612 Ensembl ENSG00000167748 ENSMUSG00000063903 UniProt P06870 P15947 RefSeq (mRNA) NM_002257 NM_010639 NM_001320331 NM_001320332 RefSeq (protein) NP_002248 NP_001307260 NP_001307261 NP_034769 Location (UCSC) Chr 19: 50.82 – 50.82 Mb Chr 7: 43.87 – 43.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. ^{[5] [6] [7]} KLK1 is a member of the peptidase S1 family.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. ^[8]

See also

• Kinin–kallikrein system
• Kininogen 1

References

1. GRCh38: Ensembl release 89: ENSG00000167748 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063903 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics. 11 (1): 77–82. doi:10.1016/0888-7543(91)90103-L. PMID   1684954.
6. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID   16800724. S2CID   436200.
7. Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID   16800723. S2CID   83910246.
8. "Entrez Gene: KLK1 kallikrein 1".

Further reading

• Clements J, Hooper J, Dong Y, Harvey T (2001). "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions" (PDF). Biol. Chem. 382 (1): 5–14. doi:10.1515/BC.2001.002. PMID   11258672. S2CID   5864448.
• Lottspeich F, Geiger R, Henschen A, Kutzbach C (1980). "N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases". Hoppe-Seyler's Z. Physiol. Chem. 360 (12): 1947–50. PMID   393608.
• Riegman PH, Vlietstra RJ, Suurmeijer L, et al. (1992). "Characterization of the human kallikrein locus". Genomics. 14 (1): 6–11. doi:10.1016/S0888-7543(05)80275-7. PMID   1385301.
• Henttu P, Lukkarinen O, Vihko P (1990). "Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate". Int. J. Cancer. 45 (4): 654–60. doi:10.1002/ijc.2910450414. PMID   1691151. S2CID   33875411.
• Qin H, Kemp J, Yip MY, et al. (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization". Hum. Hered. 41 (4): 222–6. doi:10.1159/000154005. PMID   1783409.
• Lu HS, Lin FK, Chao L, Chao J (1989). "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation". Int. J. Pept. Protein Res. 33 (4): 237–49. doi:10.1111/j.1399-3011.1989.tb01277.x. PMID   2666327.
• Angermann A, Bergmann C, Appelhans H (1990). "Cloning and expression of human salivary-gland kallikrein in Escherichia coli". Biochem. J. 262 (3): 787–93. doi:10.1042/bj2620787. PMC   1133342 . PMID   2686621.
• Evans BA, Yun ZX, Close JA, et al. (1988). "Structure and chromosomal localization of the human renal kallikrein gene". Biochemistry. 27 (9): 3124–9. doi:10.1021/bi00409a003. PMID   2898948.
• Fukushima D, Kitamura N, Nakanishi S (1986). "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein". Biochemistry. 24 (27): 8037–43. doi:10.1021/bi00348a030. PMID   3004571.
• Kellermann J, Lottspeich F, Geiger R, Deutzmann R (1988). "Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites". Protein Seq. Data Anal. 1 (3): 177–82. PMID   3163150.
• Takahashi S, Irie A, Katayama Y, et al. (1986). "N-terminal amino acid sequence of human urinary prokallikrein". J. Biochem. 99 (3): 989–92. doi:10.1093/oxfordjournals.jbchem.a135563. PMID   3635530.
• Baker AR, Shine J (1986). "Human kidney kallikrein: cDNA cloning and sequence analysis". DNA. 4 (6): 445–50. doi:10.1089/dna.1985.4.445. PMID   3853975.
• Del Nery E, Chagas JR, Juliano MA, et al. (1996). "Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments". Biochem. J. 312 (1): 233–8. doi:10.1042/bj3120233. PMC   1136249 . PMID   7492318.
• Chen LM, Richards GP, Chao L, Chao J (1995). "Molecular cloning, purification and in situ localization of human colon kallikrein". Biochem. J. 307 (2): 481–6. doi:10.1042/bj3070481. PMC   1136673 . PMID   7733886.
• Clements J, Mukhtar A, Ehrlich A, Yap B (1995). "Glandular kallikrein gene expression in the human uterus". Braz. J. Med. Biol. Res. 27 (8): 1855–63. PMID   7749374.
• Lin FK, Lin CH, Chou CC, et al. (1993). "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes". Biochim. Biophys. Acta. 1173 (3): 325–8. doi:10.1016/0167-4781(93)90131-v. PMID   7916636.
• Gomes RA, Juliano L, Chagas JR, Hial V (1997). "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney". Can. J. Physiol. Pharmacol. 75 (6): 757–61. doi:10.1139/cjpp-75-6-757. PMID   9276160.
• Bourgeois L, Brillard-Bourdet M, Deperthes D, et al. (1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2". J. Biol. Chem. 272 (47): 29590–5. doi: 10.1074/jbc.272.47.29590 . PMID   9368023.
• Chen VC, Chao L, Chao J (2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis". Biochim. Biophys. Acta. 1479 (1–2): 237–46. doi:10.1016/S0167-4838(00)00044-3. PMID   10862973.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.160 Archived 2007-11-03 at the Wayback Machine