KLK15

Last updated
KLK15
Identifiers
Aliases KLK15 , ACO, HSRNASPH, kallikrein related peptidase 15
External IDs OMIM: 610601 MGI: 2447533 HomoloGene: 77571 GeneCards: KLK15
Orthologs
SpeciesHumanMouse
Entrez

55554

317652

Ensembl

ENSG00000174562

ENSMUSG00000055193

UniProt

Q9H2R5

n/a

RefSeq (mRNA)

NM_174865

RefSeq (protein)

NP_001264010
NP_001264011
NP_059979

n/a

Location (UCSC) Chr 19: 50.83 – 50.84 Mb Chr 7: 43.58 – 43.59 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene. [5] [6] [7] [8] [9]

Contents

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [9]

Related Research Articles

Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.

<span class="mw-page-title-main">KLK1</span> Protein-coding gene in the species Homo sapiens

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.

<span class="mw-page-title-main">KLK2</span> Protein-coding gene in the species Homo sapiens

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.

<span class="mw-page-title-main">ST14</span> Protein-coding gene in the species Homo sapiens

Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.

<span class="mw-page-title-main">KLK6</span> Protein-coding gene in the species Homo sapiens

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene. Kallikrein-6 is also referred to as neurosin, protease M, hK6, or zyme. It is a 223 amino acid sequence, derived from its 244 original form, which contains a 16 residue presignal and 5 residue activation peptide.

<span class="mw-page-title-main">KLK10</span> Protein-coding gene in the species Homo sapiens

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.

<span class="mw-page-title-main">Kallikrein-5</span> Protein-coding gene in the species Homo sapiens

Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

<span class="mw-page-title-main">KLK4</span> Mammalian protein found in Homo sapiens

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

<span class="mw-page-title-main">KLK11</span> Protein-coding gene in the species Homo sapiens

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

<span class="mw-page-title-main">SEMG2</span> Protein-coding gene in the species Homo sapiens

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.

<span class="mw-page-title-main">SERPINB6</span> Protein-coding gene in the species Homo sapiens

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.

<span class="mw-page-title-main">KLK7</span> Protein-coding gene in the species Homo sapiens

Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).

<span class="mw-page-title-main">KLK13</span> Gene of the species Homo sapiens

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.

<span class="mw-page-title-main">KLK8</span> Protein-coding gene in the species Homo sapiens

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.

<span class="mw-page-title-main">KLK14</span> Protein-coding gene in the species Homo sapiens

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.

<span class="mw-page-title-main">SIGLEC5</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170.

<span class="mw-page-title-main">KLK12</span> Protein-coding gene in the species Homo sapiens

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.

<span class="mw-page-title-main">SIGLEC9</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.

<span class="mw-page-title-main">BCL2L12</span> Protein-coding gene in the species Homo sapiens

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

<span class="mw-page-title-main">KLK9</span> Protein-coding gene in the species Homo sapiens

Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174562 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055193 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Yousef GM, Scorilas A, Jung K, Ashworth LK, Diamandis EP (Feb 2001). "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer". J Biol Chem. 276 (1): 53–61. doi: 10.1074/jbc.M005432200 . PMID   11010966.
  6. ↑ Yousef GM, Scorilas A, Magklara A, Memari N, Ponzone R, Sismondi P, Biglia N, Abd Ellatif M, Diamandis EP (Nov 2002). "The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer". Br J Cancer. 87 (11): 1294–300. doi:10.1038/sj.bjc.6600590. PMC   2408911 . PMID   12439720.
  7. ↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID   16800724. S2CID   436200.
  8. ↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID   16800723. S2CID   83910246.
  9. 1 2 "Entrez Gene: KLK15 kallikrein-related peptidase 15".

Further reading


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