KLK12

KLK12
Identifiers
Aliases	KLK12 , KLK-L5, KLKL5, kallikrein related peptidase 12
External IDs	OMIM: 605539 MGI: 1916761 HomoloGene: 44690 GeneCards: KLK12
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,035,230 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,423,009 bp
RNA expression pattern
	Top expressed in
	gums; ; cavity of mouth; ; cervix epithelium; ; body of tongue; ; superior surface of tongue; ; vagina; ; minor salivary gland; ; amniotic fluid; ; pancreatic ductal cell; ; periodontal fiber;
	Top expressed in
	esophagus; ; lip; ; stomach; ; skin of back; ; aorta; ; ascending aorta; ; nucleus of brain; ; placenta; ; cerebrum; ; basal forebrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity ; serine-type peptidase activity ; peptidase activity ; serine-type endopeptidase activity ;
Cellular component	extracellular region ; extracellular space ; secretory granule ;
Biological process	proteolysis ; cornification ;
	Sources:Amigo / QuickGO
Orthologs
	43849
	69511
	ENSG00000186474
	ENSMUSG00000044430
	Q9UKR0
	B2RVZ0
NM_019598 ; NM_145894 ; NM_145895 ; NM_001370125 ; NM_001370126 ;
	NM_001370127 ; NM_001370128
	NM_027097
NP_062544 ; NP_665901 ; NP_665902 ; NP_001357054 ; NP_001357055 ;
	NP_001357056 ; NP_001357057
	NP_081373
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.^[5]^[6]^[7]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[7]

Related Research Articles

Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene.

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.

<span class="mw-page-title-main">Kallikrein-5</span> Protein-coding gene in the species Homo sapiens

Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene.

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.

<span class="mw-page-title-main">KLK7</span> Protein-coding gene in the species Homo sapiens

Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19 (19q13).

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.

<span class="mw-page-title-main">KLK8</span> Protein-coding gene in the species Homo sapiens

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.

Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14. SPINK6 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK9.

Stratum corneum chymotryptic enzyme is an enzyme. This enzyme catalyses the following chemical reaction

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186474 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044430 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
1 2 "Entrez Gene: KLK12 kallikrein-related peptidase 12".

External links

The MEROPS online database for peptidases and their inhibitors: S01.020

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186474 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044430 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16800724-5] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-6] Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-7] 1 2 "Entrez Gene: KLK12 kallikrein-related peptidase 12".

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KLK12

Contents

Related Research Articles

References

Further reading

External links