Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3.
Properdin is the only known positive regulator of complement activation that stabilizes the alternative pathway convertases. It is found in the blood serum of more complex animals.
Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system. Once activated, about 12-18 molecules of C9 polymerize to form pores in target cell membranes, causing lysis and cell death. C9 is one member of the complement membrane attack complex (MAC), which also includes complement components C5b, C6, C7 and C8. The formation of the MAC occurs through three distinct pathways: the classical, alternative, and lectin pathways. Pore formation by C9 is an important way that bacterial cells are killed during an infection, and the target cell is often covered in multiple MACs. The clinical impact of a deficiency in C9 is an infection with the gram-negative bacterium Neisseria meningitidis.
Complement component 5 is a protein that in humans is encoded by the C5 gene.
CD46 complement regulatory protein also known as CD46 and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. CD46 is an inhibitory complement receptor.
Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene. The gem-associated proteins are those found in the gems of Cajal bodies.
Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene. The gem-associated proteins are those found in the gems of Cajal bodies.
Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.
Protein Dom3Z is a protein that in humans is encoded by the DOM3Z gene.
Sarcoglycan zeta also known as SGCZ is a protein which in humans is encoded by the SGCZ gene.
Syndetin is a protein that in humans is encoded by the VPS50 gene. It is a component of the EARP complex that is involved in endocytic recycling.
Beta-tectorin is a protein that in humans is encoded by the TECTB gene.
Complement component 4B is a protein that in humans is encoded by the C4B gene.
Dynein, axonemal, heavy chain 7 is a protein in humans that is encoded by the DNAH7 gene.
Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene.
V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene.
TELO2 interacting protein 2 is a protein that in humans is encoded by the TTI2 gene.
Mediator complex subunit 10 (Med10) is a protein that in humans is encoded by the MED10 gene.
Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.
Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.
