CADPS

CADPS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WI1
Identifiers
Aliases	CADPS , CADPS1, CAPS, CAPS1, UNC-31, Ca2+ dependent secretion activator, calcium dependent secretion activator
External IDs	OMIM: 604667 MGI: 1350922 HomoloGene: 2755 GeneCards: CADPS
Gene location (Human)
Chr.	Chromosome 3 (human)
End	62,875,416 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	12,823,079 bp
RNA expression pattern
	Top expressed in
	pons; ; Brodmann area 46; ; prefrontal cortex; ; Brodmann area 9; ; cerebellar cortex; ; cerebellar hemisphere; ; superior frontal gyrus; ; postcentral gyrus; ; islet of Langerhans; ; cingulate gyrus;
	Top expressed in
	pontine nuclei; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; mammillary body; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; superior colliculus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; protein kinase binding ; metal ion binding ; lipid binding ;
Cellular component	membrane ; cytoplasmic vesicle ; cytosol ; cell junction ; synapse ; cytoplasmic vesicle membrane ; presynapse ; glutamatergic synapse ;
Biological process	protein transport ; synaptic vesicle priming ; catecholamine secretion ; vesicle organization ; exocytosis ; synaptic vesicle exocytosis ; dense core granule exocytosis ; presynaptic dense core vesicle exocytosis ; positive regulation of exocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	8618
	27062
	ENSG00000163618
	ENSMUSG00000054423
	Q9ULU8
	Q80TJ1
	NM_003716 ; NM_183393 ; NM_183394
	NM_001042617 ; NM_012061 ; NM_001359919 ; NM_001359920 ; NM_001359921 Contents References ; External links ; Further reading ;
	NP_003707 ; NP_899630 ; NP_899631
	NP_001036082 ; NP_036191 ; NP_001346848 ; NP_001346849 ; NP_001346850
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.^[5]^[6]

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163618 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054423 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell. 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133. S2CID 29122392.
1 2 "Entrez Gene: CADPS Ca2+-dependent secretion activator".

External links

Human CADPS genome location and CADPS gene details page in the UCSC Genome Browser .
Human CAPS genome location and CAPS gene details page in the UCSC Genome Browser .

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Nishizaki T, Walent JH, Kowalchyk JA, Martin TF (1992). "A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C." J. Biol. Chem. 267 (33): 23972–81. doi: 10.1016/S0021-9258(18)35932-5 . PMID 1429734.
Ann K, Kowalchyk JA, Loyet KM, Martin TF (1997). "Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis". J. Biol. Chem. 272 (32): 19637–40. doi: 10.1074/jbc.272.32.19637 . PMID 9289490.
Loyet KM, Kowalchyk JA, Chaudhary A, et al. (1998). "Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis". J. Biol. Chem. 273 (14): 8337–43. doi: 10.1074/jbc.273.14.8337 . PMID 9525942.
Berwin B, Floor E, Martin TF (1998). "CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis". Neuron. 21 (1): 137–45. doi: 10.1016/S0896-6273(00)80521-8 . PMID 9697858.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID 10574461.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family". Genomics. 81 (3): 279–91. doi:10.1016/S0888-7543(02)00040-X. PMID 12659812.
Speidel D, Varoqueaux F, Enk C, et al. (2004). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function". J. Biol. Chem. 278 (52): 52802–9. doi: 10.1074/jbc.M304727200 . PMID 14530279.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)". Biochem. Pharmacol. 69 (10): 1451–61. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163618 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054423 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1516133-5] Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell. 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133. S2CID 29122392.

[entrez-6] 1 2 "Entrez Gene: CADPS Ca2+-dependent secretion activator".

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CADPS

Contents

Related Research Articles

References

External links

Further reading