CALN1

CALN1
Identifiers
Aliases	CALN1 , CABP8, calneuron 1
External IDs	OMIM: 607176; MGI: 2155987; HomoloGene: 10966; GeneCards: CALN1; OMA:CALN1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q11.22 Start 71,779,491 bp [1] End 72,447,151 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G1.3- G2 Start 130,398,296 bp [2] End 130,876,253 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis pons pars reticulata cerebellar hemisphere pars compacta right hemisphere of cerebellum entorhinal cortex external globus pallidus Brodmann area 46 middle temporal gyrus Top expressed in nucleus accumbens dorsal striatum olfactory tubercle facial motor nucleus deep cerebellar nuclei cerebellar cortex globus pallidus cerebellar vermis lobe of cerebellum temporal lobe More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 83698 140904 Ensembl ENSG00000183166 ENSMUSG00000060371 UniProt Q9BXU9 Q9JJG7 RefSeq (mRNA) NM_001017440 NM_031468 NM_001363460 NM_021371 NM_181045 RefSeq (protein) NP_001017440 NP_113656 NP_001350389 NP_067346 NP_851388 Location (UCSC) Chr 7: 71.78 – 72.45 Mb Chr 5: 130.4 – 130.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcium-binding protein 8 is a protein that in humans is encoded by the CALN1 gene. ^{[5] [6]} Alternative splicing results in multiple transcript variants. ^[6]

Function

This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000183166 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060371 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wu YQ, Lin X, Liu CM, Jamrich M, Shaffer LG (Apr 2001). "Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily". Molecular Genetics and Metabolism. 72 (4): 343–50. doi:10.1006/mgme.2001.3160. PMID   11286509.
6. "Entrez Gene: CALN1 calneuron 1".
7. McCue HV, Haynes LP, Burgoyne RD (Aug 2010). "The diversity of calcium sensor proteins in the regulation of neuronal function". Cold Spring Harbor Perspectives in Biology. 2 (8) a004085. doi:10.1101/cshperspect.a004085. PMC   2908765 . PMID   20668007.

External links

• Human CALN1 genome location and CALN1 gene details page in the UCSC Genome Browser .

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.