CALY

CALY
Identifiers
Aliases	CALY , DRD1IP, NSG3, calcyon neuron specific vesicular protein
External IDs	OMIM: 604647 MGI: 1915816 HomoloGene: 9256 GeneCards: CALY
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,336,935 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,662,461 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; hypothalamus; ; pituitary gland; ; caudate nucleus; ; prefrontal cortex; ; anterior pituitary; ; amygdala; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; putamen;
	Top expressed in
	superior frontal gyrus; ; hippocampus proper; ; arcuate nucleus; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; temporal lobe; ; amygdala; ; nucleus accumbens; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; clathrin light chain binding ; protein-containing complex binding ; cargo receptor activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; cytoplasmic vesicle membrane ; cytoplasmic vesicle ; membrane ; endosome ; postsynaptic endocytic zone ; glutamatergic synapse ;
Biological process	clathrin coat assembly ; dopamine receptor signaling pathway ; positive regulation of endocytosis ; endocytosis ; endosomal transport ; postsynaptic neurotransmitter receptor internalization ;
	Sources:Amigo / QuickGO
Orthologs
	50632
	68566
	ENSG00000130643
	ENSMUSG00000025468
	Q9NYX4
	Q9DCA7
	NM_015722 ; NM_001321617
	NM_001190385 ; NM_001190386 ; NM_026769
	NP_001308546 ; NP_056537
	NP_001177314 ; NP_001177315 ; NP_081045
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 11, 2023

Neuron-specific vesicular protein calcyon is a protein that in humans is encoded by the CALY gene.^[5]^[6] Its alternative name is Calcyon.

Function

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with dopamine receptor D1 and may interact with other DA receptor subtypes and/or GPCRs.^[6]

Interactions

SPARCL1 (hevin)^[7]

Related Research Articles

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SPARC-like protein 1, also known as hevin, is a secreted protein with high structural similarity to SPARC. It interacts with the extracellular matrix to create intermediate states of cell adhesion. Due to its dynamic extracellular roles, being implicated in cancer metastasis and inflammation, it is considered a matricellular protein. In humans hevin is encoded by the SPARCL1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130643 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025468 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Heijtz RD, Alexeyenko A, Castellanos FX (July 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD". Behavioral and Brain Functions. 3 (1): 33. doi: 10.1186/1744-9081-3-33 . PMC 1949817 . PMID 17623072.
1 2 "CALY calcyon neuron specific vesicular protein [ Homo sapiens (human) ]".
↑ Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, et al. (March 2021). "Hevin-calcyon interaction promotes synaptic reorganization after brain injury". Cell Death and Differentiation. 28 (9): 2571–2588. doi: 10.1038/s41418-021-00772-5 . PMC 8408247 . PMID 33753902.

Milligan G, White JH (October 2001). "Protein-protein interactions at G-protein-coupled receptors". Trends in Pharmacological Sciences. 22 (10): 513–8. doi:10.1016/S0165-6147(00)01801-0. PMID 11583808.
Ali MK, Bergson C (December 2003). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane". The Journal of Biological Chemistry. 278 (51): 51654–63. doi: 10.1074/jbc.M305803200 . PMID 14534309.
Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J (February 2004). "CALCYON gene variation, schizophrenia, and cocaine dependence". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 125B (1): 25–30. doi: 10.1002/ajmg.b.20092 . PMID 14755439. S2CID 24881261.
Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, Malone M, Tannock R, Schachar R, Kennedy JL, Barr CL (December 2005). "Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder". Molecular Psychiatry. 10 (12): 1117–25. doi:10.1038/sj.mp.4001737. PMID 16172615. S2CID 25367235.
Xiao J, Dai R, Negyessy L, Bergson C (June 2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis". The Journal of Biological Chemistry. 281 (22): 15182–93. doi: 10.1074/jbc.M600265200 . PMID 16595675.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Kruusmägi M, Zelenin S, Brismar H, Scott L (October 2007). "Intracellular dynamics of calcyon, a neuron-specific vesicular protein". NeuroReport. 18 (15): 1547–51. doi:10.1097/WNR.0b013e3282f03f51. PMID 17885599. S2CID 24544827.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130643 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025468 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17623072-5] Heijtz RD, Alexeyenko A, Castellanos FX (July 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD". Behavioral and Brain Functions. 3 (1): 33. doi: 10.1186/1744-9081-3-33 . PMC 1949817 . PMID 17623072.

[entrez-6] 1 2 "CALY calcyon neuron specific vesicular protein [ Homo sapiens (human) ]".

[KimJung2021-7] Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, et al. (March 2021). "Hevin-calcyon interaction promotes synaptic reorganization after brain injury". Cell Death and Differentiation. 28 (9): 2571–2588. doi: 10.1038/s41418-021-00772-5 . PMC 8408247 . PMID 33753902.

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CALY

Contents

Function

Interactions

Related Research Articles

References

Further reading