CALY

CALY
Identifiers
Aliases	CALY , DRD1IP, NSG3, calcyon neuron specific vesicular protein
External IDs	OMIM: 604647; MGI: 1915816; HomoloGene: 9256; GeneCards: CALY; OMA:CALY - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.3 Start 133,324,072 bp [1] End 133,336,935 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F4 Start 139,649,793 bp [2] End 139,662,461 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens right frontal lobe hypothalamus pituitary gland anterior cingulate cortex caudate nucleus prefrontal cortex anterior pituitary right hemisphere of cerebellum amygdala Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus hippocampus proper nucleus of stria terminalis arcuate nucleus central gray substance of midbrain ventromedial nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding clathrin light chain binding protein-containing complex binding cargo receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane cytoplasmic vesicle membrane cytoplasmic vesicle membrane endosome postsynaptic endocytic zone glutamatergic synapse Biological process clathrin coat assembly dopamine receptor signaling pathway positive regulation of endocytosis endocytosis endosomal transport postsynaptic neurotransmitter receptor internalization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50632 68566 Ensembl ENSG00000130643 ENSMUSG00000025468 UniProt Q9NYX4 Q9DCA7 RefSeq (mRNA) NM_015722 NM_001321617 NM_001190385 NM_001190386 NM_026769 RefSeq (protein) NP_001308546 NP_056537 NP_001177314 NP_001177315 NP_081045 Location (UCSC) Chr 10: 133.32 – 133.34 Mb Chr 7: 139.65 – 139.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuron-specific vesicular protein calcyon is a protein that in humans is encoded by the CALY gene. ^{[5] [6]} Its alternative name is Calcyon.

Function

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with dopamine receptor D1 and may interact with other DA receptor subtypes and/or GPCRs. ^[6]

Interactions

• SPARCL1 (hevin) ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000130643 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025468 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Heijtz RD, Alexeyenko A, Castellanos FX (July 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD". Behavioral and Brain Functions. 3 (1): 33. doi: 10.1186/1744-9081-3-33 . PMC   1949817 . PMID   17623072.
6. "CALY calcyon neuron specific vesicular protein [ Homo sapiens (human) ]".
7. Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, et al. (March 2021). "Hevin-calcyon interaction promotes synaptic reorganization after brain injury". Cell Death and Differentiation. 28 (9): 2571–2588. doi: 10.1038/s41418-021-00772-5 . PMC   8408247 . PMID   33753902.

Further reading

• Milligan G, White JH (October 2001). "Protein-protein interactions at G-protein-coupled receptors". Trends in Pharmacological Sciences. 22 (10): 513–8. doi:10.1016/S0165-6147(00)01801-0. PMID   11583808.
• Ali MK, Bergson C (December 2003). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane". The Journal of Biological Chemistry. 278 (51): 51654–63. doi: 10.1074/jbc.M305803200 . PMID   14534309.
• Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J (February 2004). "CALCYON gene variation, schizophrenia, and cocaine dependence". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 125B (1): 25–30. doi: 10.1002/ajmg.b.20092 . PMID   14755439. S2CID   24881261.
• Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, Malone M, Tannock R, Schachar R, Kennedy JL, Barr CL (December 2005). "Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder". Molecular Psychiatry. 10 (12): 1117–25. doi:10.1038/sj.mp.4001737. PMID   16172615. S2CID   25367235.
• Xiao J, Dai R, Negyessy L, Bergson C (June 2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis". The Journal of Biological Chemistry. 281 (22): 15182–93. doi: 10.1074/jbc.M600265200 . PMID   16595675.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Kruusmägi M, Zelenin S, Brismar H, Scott L (October 2007). "Intracellular dynamics of calcyon, a neuron-specific vesicular protein". NeuroReport. 18 (15): 1547–51. doi:10.1097/WNR.0b013e3282f03f51. PMID   17885599. S2CID   24544827.