SPARCL1

SPARCL1
Identifiers
Aliases	SPARCL1 , MAST 9, MAST9, PIG33, SC1, SPARC like 1
External IDs	OMIM: 606041; MGI: 108110; HomoloGene: 3438; GeneCards: SPARCL1; OMA:SPARCL1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q22.1 Start 87,473,335 bp [1] End 87,531,061 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 E5|5 50.55 cM Start 104,226,977 bp [2] End 104,261,599 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus postcentral gyrus superior frontal gyrus Brodmann area 23 orbitofrontal cortex external globus pallidus Region I of hippocampus proper occipital lobe Brodmann area 46 primary visual cortex Top expressed in deep cerebellar nuclei dorsal tegmental nucleus medial vestibular nucleus cerebellar vermis ventral tegmental area globus pallidus pontine nuclei dorsomedial hypothalamic nucleus lobe of cerebellum paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding collagen binding extracellular matrix binding protein binding Cellular component extracellular exosome extracellular space endoplasmic reticulum lumen extracellular region collagen-containing extracellular matrix glutamatergic synapse Biological process signal transduction anatomical structure development post-translational protein modification synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8404 13602 Ensembl ENSG00000152583 ENSMUSG00000029309 UniProt Q14515 P70663 RefSeq (mRNA) NM_004684 NM_001128310 NM_001291976 NM_001291977 NM_010097 NM_001359014 NM_001359016 RefSeq (protein) NP_001121782 NP_001278905 NP_001278906 NP_004675 NP_034227 NP_001345943 NP_001345945 Location (UCSC) Chr 4: 87.47 – 87.53 Mb Chr 5: 104.23 – 104.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SPARC-like protein 1 (SPARCL1 or SC1), also known as hevin (short for high endothelial venule protein), is a secreted protein with high structural similarity to SPARC. ^{[5] [6]}

Biology

It interacts with the extracellular matrix to create intermediate states of cell adhesion. ^[7] Due to its dynamic extracellular roles, it is implicated in cancer metastasis and inflammation and it is considered a matricellular protein. ^{[8] [9]} In humans hevin is encoded by the SPARCL1 gene. ^{[10] [11]} Hevin is produced by astrocytes. It is involved in synapse formation, function, plasticity, and elimination as well as brain chemistry regulation. ^[12]

Interactions

• CALY (calcyon) ^[13]

See also

• Thrombospondin
• Tenascin

References

1. GRCh38: Ensembl release 89: ENSG00000152583 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029309 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Girard JP, Springer TA (January 1995). "Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC". Immunity. 2 (1): 113–23. doi: 10.1016/1074-7613(95)90083-7 . PMID   7600298.
6. Hambrock HO, Nitsche DP, Hansen U, Bruckner P, Paulsson M, Maurer P, Hartmann U (March 2003). "SC1/hevin. An extracellular calcium-modulated protein that binds collagen I". The Journal of Biological Chemistry. 278 (13): 11351–8. doi: 10.1074/jbc.M212291200 . PMID   12538579.
7. Sullivan MM, Barker TH, Funk SE, Karchin A, Seo NS, Höök M, et al. (September 2006). "Matricellular hevin regulates decorin production and collagen assembly". The Journal of Biological Chemistry. 281 (37): 27621–32. doi: 10.1074/jbc.M510507200 . PMID   16844696.
8. Morris AH, Kyriakides TR (July 2014). "Matricellular proteins and biomaterials". Matrix Biology. 37: 183–91. doi:10.1016/j.matbio.2014.03.002. PMC   4167162 . PMID   24657843.
9. Sullivan MM, Sage EH (June 2004). "Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family". The International Journal of Biochemistry & Cell Biology. 36 (6): 991–6. doi:10.1016/j.biocel.2004.01.017. PMID   15094114.
10. Schraml P, Shipman R, Stulz P, Ludwig CU (March 1993). "cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST)". Trends in Genetics. 9 (3): 70–1. doi:10.1016/0168-9525(93)90216-5. PMID   8488563.
11. "Entrez Gene: SPARCL1 SPARC-like 1 (mast9, hevin)".
12. McClure, Paul (2025-05-15). "Natural molecule reverses age- and dementia-related cognitive decline". New Atlas. Retrieved 2025-05-17.
13. Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, et al. (March 2021). "Hevin-calcyon interaction promotes synaptic reorganization after brain injury". Cell Death and Differentiation. 28 (9): 2571–2588. doi: 10.1038/s41418-021-00772-5 . ISSN   1350-9047. PMC   8408247 . PMID   33753902.

Further reading

• Girard JP, Springer TA (February 1996). "Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules". The Journal of Biological Chemistry. 271 (8): 4511–7. doi: 10.1074/jbc.271.8.4511 . PMID   8626806.
• Claeskens A, Ongenae N, Neefs JM, Cheyns P, Kaijen P, Cools M, Kutoh E (March 2000). "Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation". British Journal of Cancer. 82 (6): 1123–30. doi:10.1054/bjoc.1999.1051. PMC   2363342 . PMID   10735494.
• Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, et al. (June 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology. 22 (6): 724–31. doi:10.1038/nbt969. PMID   15146195. S2CID   36630738.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Li Y, Aroca-Aguilar JD, Ghosh S, Sánchez-Sánchez F, Escribano J, Coca-Prados M (January 2006). "Interaction of myocilin with the C-terminal region of hevin". Biochemical and Biophysical Research Communications. 339 (3): 797–804. doi:10.1016/j.bbrc.2005.11.082. PMID   16316624.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Scalabrini D, Fenoglio C, Scarpini E, De Riz M, Comi C, Venturelli E, et al. (October 2007). "Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis". Neuroscience Letters. 425 (3): 173–6. doi:10.1016/j.neulet.2007.08.020. PMID   17825989. S2CID   9381979.