CAP2

CAP2
Identifiers
Aliases	CAP2 , CAP, adenylate cyclase-associated protein, 2 (yeast), cyclase associated actin cytoskeleton regulatory protein 2
External IDs	OMIM: 618385 MGI: 1914502 HomoloGene: 101397 GeneCards: CAP2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	17,557,780 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	46,803,757 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; vastus lateralis muscle; ; endothelial cell; ; deltoid muscle; ; gastrocnemius muscle; ; frontal pole; ; tibialis anterior muscle; ; triceps brachii muscle; ; middle temporal gyrus; ; Brodmann area 10;
	Top expressed in
	triceps brachii muscle; ; vastus lateralis muscle; ; temporal muscle; ; olfactory tubercle; ; primary motor cortex; ; dentate gyrus; ; Region I of hippocampus proper; ; gastrocnemius muscle; ; superior frontal gyrus; ; cingulate gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; actin binding ; adenylate cyclase binding ; identical protein binding ;
Cellular component	plasma membrane ; membrane ; cortical actin cytoskeleton ; postsynaptic density ;
Biological process	establishment or maintenance of cell polarity ; cytoskeleton organization ; signal transduction ; activation of adenylate cyclase activity ; actin polymerization or depolymerization ; cell morphogenesis ; regulation of adenylate cyclase activity ;
	Sources:Amigo / QuickGO
Orthologs
	10486
	67252
	ENSG00000112186
	ENSMUSG00000021373
	P40123
	Q9CYT6
	NM_006366 ; NM_001363533 ; NM_001363534
	NM_026056
	NP_006357 ; NP_001350462 ; NP_001350463
	NP_080332
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 17, 2024

Adenylyl cyclase-associated protein 2 is an enzyme that in humans is encoded by the CAP2 gene.^[5]^[6]^[7]

Function

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin.^[7]

Interactions

CAP2 has been shown to interact with CAP1.^[6]

Related Research Articles

Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene.

Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene.

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Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.

Adenylyl cyclase-associated protein 1 is an enzyme that in humans is encoded by the CAP1 gene.

Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene. It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 can be found on chromosome 5 and the "MIR2113-POU3F2" region of chromosome 6, with a length of 1091 amino-acids. An essential cofactor for ADCY2 is magnesium; two ions bind per subunit.

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.

<span class="mw-page-title-main">ADCY9</span> Protein-coding gene in the species Homo sapiens

Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene.

Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.

40S ribosomal protein S21 is a protein, encoded in humans by the RPS21 gene.

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.

Coronin-1C is a protein that in humans is encoded by the CORO1C gene.

60S ribosomal protein L13 is a protein that in humans is encoded by the RPL13 gene.

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.

Adenylyl cyclase type 4 is an enzyme that in humans is encoded by the ADCY4 gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene.

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.

Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112186 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021373 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yu G, Swiston J, Young D (Jun 1994). "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins". Journal of Cell Science. 107 (6): 1671–8. doi:10.1242/jcs.107.6.1671. PMID 7962207.
1 2 Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". Journal of Cellular Biochemistry. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950. S2CID 46076387.
1 2 "Entrez Gene: CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)".

External links

Human CAP2 genome location and CAP2 gene details page in the UCSC Genome Browser .