CAP2

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CAP2
Identifiers
Aliases	CAP2 , CAP, adenylate cyclase-associated protein, 2 (yeast), cyclase associated actin cytoskeleton regulatory protein 2
External IDs	OMIM: 618385; MGI: 1914502; HomoloGene: 101397; GeneCards: CAP2; OMA:CAP2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.3 Start 17,393,595 bp [1] End 17,557,780 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A5 Start 46,655,324 bp [2] End 46,803,757 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii Brodmann area 23 Skeletal muscle tissue of rectus abdominis vastus lateralis muscle endothelial cell glutes deltoid muscle muscle of thigh gastrocnemius muscle frontal pole Top expressed in muscle of thigh triceps brachii muscle vastus lateralis muscle temporal muscle olfactory tubercle primary motor cortex dentate gyrus Region I of hippocampus proper gastrocnemius muscle superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin binding adenylate cyclase binding identical protein binding Cellular component plasma membrane membrane cortical actin cytoskeleton postsynaptic density Biological process establishment or maintenance of cell polarity cytoskeleton organization signal transduction activation of adenylate cyclase activity actin polymerization or depolymerization cell morphogenesis regulation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10486 67252 Ensembl ENSG00000112186 ENSMUSG00000021373 UniProt P40123 Q9CYT6 RefSeq (mRNA) NM_006366 NM_001363533 NM_001363534 NM_026056 RefSeq (protein) NP_006357 NP_001350462 NP_001350463 NP_080332 Location (UCSC) Chr 6: 17.39 – 17.56 Mb Chr 13: 46.66 – 46.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adenylyl cyclase-associated protein 2 is an enzyme that in humans is encoded by the CAP2 gene. ^{[5] [6] [7]}

Function

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. ^[7]

Interactions

CAP2 has been shown to interact with CAP1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000112186 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021373 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yu G, Swiston J, Young D (Jun 1994). "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins". Journal of Cell Science. 107 (6): 1671–8. doi:10.1242/jcs.107.6.1671. PMID   7962207.
6. Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". Journal of Cellular Biochemistry. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID   8761950. S2CID   46076387.
7. "Entrez Gene: CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)".

External links

• Human CAP2 genome location and CAP2 gene details page in the UCSC Genome Browser .

Further reading

• Shibata R, Mori T, Du W, Chuma M, Gotoh M, Shimazu M, Ueda M, Hirohashi S, Sakamoto M (Sep 2006). "Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis". Clinical Cancer Research. 12 (18): 5363–8. doi:10.1158/1078-0432.CCR-05-2245. PMID   17000669. S2CID   12928459.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.