CASP8AP2

CASP8AP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LR8
Identifiers
Aliases	CASP8AP2 , CED-4, FLASH, RIP25, caspase 8 associated protein 2
External IDs	OMIM: 606880 MGI: 1349399 HomoloGene: 8066 GeneCards: CASP8AP2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	89,874,436 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	32,653,265 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; ganglionic eminence; ; thymus; ; endometrium; ; lymph node; ; bone marrow cells; ; smooth muscle tissue; ; monocyte; ; skeletal muscle tissue;
	Top expressed in
	secondary oocyte; ; cumulus cell; ; primitive streak; ; abdominal wall; ; medial ganglionic eminence; ; maxillary prominence; ; conjunctival fornix; ; medullary collecting duct; ; renal corpuscle; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activator activity involved in apoptotic process ; DNA binding ; death receptor binding ; transcription corepressor activity ; SUMO polymer binding ; protein binding ; cysteine-type endopeptidase activator activity involved in apoptotic process ;
Cellular component	cytoplasm ; PML body ; mitochondrion ; nucleus ; nucleoplasm ;
Biological process	regulation of transcription, DNA-templated ; Fas signaling pathway ; transcription, DNA-templated ; cellular response to mechanical stimulus ; apoptotic signaling pathway ; cell cycle ; activation of cysteine-type endopeptidase activity involved in apoptotic process ; extrinsic apoptotic signaling pathway via death domain receptors ; signal transduction ; apoptotic process ; negative regulation of nucleic acid-templated transcription ;
	Sources:Amigo / QuickGO
Orthologs
	9994
	26885
	ENSG00000118412 ; ENSG00000288475
	ENSMUSG00000028282
	Q9UKL3
	Q9WUF3
	NM_012115 ; NM_001137667 ; NM_001137668
	NM_001122978 ; NM_011997
	NP_001131139 ; NP_001131140 ; NP_036247
	NP_001116450 ; NP_036127
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

CASP8-associated protein 2 is a protein, that in humans is encoded by the CASP8AP2 gene.^[5]^[6]^[7]^[8]

Function

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Researches of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex, that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.^[8]

Interactions

CASP8AP2 has been shown to interact with TRAF2.^[9]

Related Research Articles

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References

1 2 3 ENSG00000288475 GRCh38: Ensembl release 89: ENSG00000118412, ENSG00000288475 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028282 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S (Jun 1999). "The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis". Nature. 398 (6730): 777–85. Bibcode:1999Natur.398..777I. doi:10.1038/19709. PMID 10235259. S2CID 2792230.
↑ Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG (Jan 2007). "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies". EMBO J. 26 (2): 391–401. doi:10.1038/sj.emboj.7601504. PMC 1783462 . PMID 17245429.
↑ Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V (Oct 2006). "FLASH is an essential component of Cajal bodies". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. Bibcode:2006PNAS..10314802B. doi: 10.1073/pnas.0604225103 . PMC 1578500 . PMID 17003126.
1 2 "Entrez Gene: CASP8AP2 CASP8 associated protein 2".
↑ Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK (Jul 2001). "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. doi: 10.1074/jbc.M102941200 . PMID 11340079.

External links

CASP8AP2 human gene location in the UCSC Genome Browser .
CASP8AP2 human gene details in the UCSC Genome Browser .

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
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[refGRCh38Ensembl-1] 1 2 3 ENSG00000288475 GRCh38: Ensembl release 89: ENSG00000118412, ENSG00000288475 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028282 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10235259-5] Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S (Jun 1999). "The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis". Nature. 398 (6730): 777–85. Bibcode:1999Natur.398..777I. doi:10.1038/19709. PMID 10235259. S2CID 2792230.

[pmid17245429-6] Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG (Jan 2007). "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies". EMBO J. 26 (2): 391–401. doi:10.1038/sj.emboj.7601504. PMC 1783462 . PMID 17245429.

[pmid17003126-7] Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V (Oct 2006). "FLASH is an essential component of Cajal bodies". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. Bibcode:2006PNAS..10314802B. doi: 10.1073/pnas.0604225103 . PMC 1578500 . PMID 17003126.

[entrez-8] 1 2 "Entrez Gene: CASP8AP2 CASP8 associated protein 2".

[pmid11340079-9] Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK (Jul 2001). "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. doi: 10.1074/jbc.M102941200 . PMID 11340079.

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