CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. [5] [6] CBLB is a member of the CBL gene family.
CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. [5] [6] CBLB is a member of the CBL gene family.
CBL-B functions as a negative regulator of T-cell activation. [7] CBL-B expression in T cells causes ligand-induced T cell receptor down-modulation, controlling the activation degree of T cells during antigen presentation. [8] [9]
Mutation of the CBLB gene has been associated with autoimmune conditions such as type 1 diabetes. [10] [11]
CBLB has been shown to interact with:
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands.
Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus.
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.
Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.
Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.
Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.
Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.
Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.
Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.
Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.
Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.
Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.
SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.
Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. It is of the Src family of tyrosine kinases.
Vinexin is a protein that in humans is encoded by the SORBS3 gene.
Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.
Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.
NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.
Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.
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