Crk-like protein is a protein that in humans is encoded by the CRKL gene. [5] [6]
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. [7]
CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1. [8] [9]
CRKL has been shown to interact with: