CBLC

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CBLC
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CBLC , CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C
External IDs OMIM: 608453 MGI: 1931457 HomoloGene: 8108 GeneCards: CBLC
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130852
NM_012116

NM_001161844
NM_023224

RefSeq (protein)

NP_001124324
NP_036248

NP_001155316
NP_075713

Location (UCSC) Chr 19: 44.78 – 44.8 Mb Chr 7: 19.51 – 19.53 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene. [5] [6] [7]

Contents

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM] [7]

Interactions

CBLC has been shown to interact with FYN [8] and Epidermal growth factor receptor. [6] [9]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000142273 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040525 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID   10362357.
  6. 1 2 Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID   10571044.
  7. 1 2 "Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c".
  8. Kim, M; Tezuka T; Suziki Y; Sugano S; Hirai M; Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. NETHERLANDS. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN   0378-1119. PMID   10571044.
  9. Keane, M M; Ettenberg S A; Nau M M; Banerjee P; Cuello M; Penninger J; Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. ENGLAND. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. ISSN   0950-9232. PMID   10362357.

Further reading