CCDC85B

CCDC85B
Identifiers
Aliases	CCDC85B , DIPA, coiled-coil domain containing 85B
External IDs	OMIM: 605360; MGI: 2147607; HomoloGene: 4989; GeneCards: CCDC85B; OMA:CCDC85B - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.1 Start 65,890,673 bp [1] End 65,891,635 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 5,503,208 bp [2] End 5,507,922 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala Brodmann area 9 right frontal lobe nucleus accumbens putamen apex of heart caudate nucleus Region I of hippocampus proper cingulate gyrus anterior cingulate cortex Top expressed in anterior horn of spinal cord facial motor nucleus endothelial cell of lymphatic vessel epithelium of lens otolith organ utricle prefrontal cortex hippocampus proper primary motor cortex cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm centrosome cytoskeleton nucleus microtubule organizing center Biological process regulation of growth cell differentiation negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of cell growth transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11007 240514 Ensembl ENSG00000175602 ENSMUSG00000095098 UniProt Q15834 Q6PDY0 RefSeq (mRNA) NM_006848 NM_001243307 NM_198616 RefSeq (protein) NP_006839 NP_001230236 NP_941018 Location (UCSC) Chr 11: 65.89 – 65.89 Mb Chr 19: 5.5 – 5.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene. ^{[5] [6] [7]}

Function

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro . ^[7]

Interactions

CCDC85B has been shown to interact with:

• C19orf25, ^[8]
• KIAA1267, ^[8]
• Keratin 17, ^[8] and
• Protein kinase N1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000175602 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000095098 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brazas R, Ganem D (Oct 1996). "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution". Science. 274 (5284): 90–4. Bibcode:1996Sci...274...90B. doi:10.1126/science.274.5284.90. PMID   8810253. S2CID   20743492.
6. Bezy O, Elabd C, Cochet O, Petersen RK, Kristiansen K, Dani C, et al. (Mar 2005). "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation". The Journal of Biological Chemistry. 280 (12): 11432–8. doi: 10.1074/jbc.M411741200 . PMID   15644333.
7. "Entrez Gene: CCDC85B coiled-coil domain containing 85B".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Human CCDC85B genome location and CCDC85B gene details page in the UCSC Genome Browser .

Further reading

• Robertson HD (Oct 1996). "How did replicating and coding RNAs first get together?". Science. 274 (5284): 66–7. Bibcode:1996Sci...274...66R. doi:10.1126/science.274.5284.66. PMID   8848724. S2CID   37715470.
• Long M, de Souza SJ, Gilbert W (May 1997). "Delta-interacting protein A and the origin of hepatitis delta antigen". Science. 276 (5313): 824–5. doi:10.1126/science.276.5313.824. PMID   9115212.
• Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, et al. (Feb 2005). "C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage". Cell Death and Differentiation. 12 (2): 153–61. doi: 10.1038/sj.cdd.4401539 . PMID   15605074.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID   17014843.