CCDC85B

CCDC85B
Identifiers
Aliases	CCDC85B , DIPA, coiled-coil domain containing 85B
External IDs	OMIM: 605360 MGI: 2147607 HomoloGene: 4989 GeneCards: CCDC85B
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,891,635 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,507,922 bp
RNA expression pattern
	Top expressed in
	amygdala; ; Brodmann area 9; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; Region I of hippocampus proper; ; cingulate gyrus; ; gastric mucosa; ; ascending aorta; ; orbitofrontal cortex;
	Top expressed in
	anterior horn of spinal cord; ; facial motor nucleus; ; otolith organ; ; utricle; ; prefrontal cortex; ; hippocampus proper; ; primary motor cortex; ; cingulate gyrus; ; nucleus accumbens; ; cerebellar vermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; centrosome ; cytoskeleton ; nucleus ; microtubule organizing center ;
Biological process	regulation of growth ; cell differentiation ; negative regulation of fat cell differentiation ; negative regulation of transcription, DNA-templated ; regulation of transcription, DNA-templated ; negative regulation of cell growth ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	11007
	240514
	ENSG00000175602
	ENSMUSG00000095098
	Q15834
	Q6PDY0
	NM_006848
	NM_001243307 ; NM_198616
	NP_006839
	NP_001230236 ; NP_941018
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 26, 2024

Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.^[5]^[6]^[7]

Function

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro .^[7]

Interactions

CCDC85B has been shown to interact with:

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175602 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000095098 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Brazas R, Ganem D (Oct 1996). "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution". Science. 274 (5284): 90–4. Bibcode:1996Sci...274...90B. doi:10.1126/science.274.5284.90. PMID 8810253. S2CID 20743492.
↑ Bezy O, Elabd C, Cochet O, Petersen RK, Kristiansen K, Dani C, et al. (Mar 2005). "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation". The Journal of Biological Chemistry. 280 (12): 11432–8. doi: 10.1074/jbc.M411741200 . PMID 15644333.
1 2 "Entrez Gene: CCDC85B coiled-coil domain containing 85B".
1 2 3 4 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

Human CCDC85B genome location and CCDC85B gene details page in the UCSC Genome Browser .

Robertson HD (Oct 1996). "How did replicating and coding RNAs first get together?". Science. 274 (5284): 66–7. Bibcode:1996Sci...274...66R. doi:10.1126/science.274.5284.66. PMID 8848724. S2CID 37715470.
Long M, de Souza SJ, Gilbert W (May 1997). "Delta-interacting protein A and the origin of hepatitis delta antigen". Science. 276 (5313): 824–5. doi:10.1126/science.276.5313.824. PMID 9115212.
Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, et al. (Feb 2005). "C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage". Cell Death and Differentiation. 12 (2): 153–61. doi: 10.1038/sj.cdd.4401539 . PMID 15605074.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000175602 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000095098 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8810253-5] Brazas R, Ganem D (Oct 1996). "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution". Science. 274 (5284): 90–4. Bibcode:1996Sci...274...90B. doi:10.1126/science.274.5284.90. PMID 8810253. S2CID 20743492.

[pmid15644333-6] Bezy O, Elabd C, Cochet O, Petersen RK, Kristiansen K, Dani C, et al. (Mar 2005). "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation". The Journal of Biological Chemistry. 280 (12): 11432–8. doi: 10.1074/jbc.M411741200 . PMID 15644333.

[entrez-7] 1 2 "Entrez Gene: CCDC85B coiled-coil domain containing 85B".

[pmid16189514-8] 1 2 3 4 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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