CCNG2

CCNG2
Identifiers
Aliases	CCNG2 , cyclin G2
External IDs	OMIM: 603203 MGI: 1095734 HomoloGene: 3208 GeneCards: CCNG2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	77,433,388 bp
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• protein kinase activity ; • cyclin-dependent protein serine/threonine kinase regulator activity ; • protein kinase binding ;
Cellular component	• cytoplasm ; • cyclin-dependent protein kinase holoenzyme complex ; • nucleus ;
Biological process	• cell cycle ; • regulation of cell cycle ; • cell division ; • regulation of cyclin-dependent protein serine/threonine kinase activity ; • GO:0007067 mitotic cell cycle ; • protein phosphorylation ; • regulation of mitotic nuclear division ; • positive regulation of cell population proliferation ; • positive regulation of cell cycle ; • GO:0007090 mitotic cell cycle phase transition ;
	Sources:Amigo / QuickGO
Orthologs
	901
	12452
	ENSG00000138764
	ENSMUSG00000029385
	Q16589
	O08918
	NM_004354
	NM_007635
	NP_004345
	NP_031661
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 05, 2021

Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene.^[4]^[5]

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.^[5]

Interactions

CCNG2 has been shown to interact with PPP2CA.^[6]

Related Research Articles

p21^Cip1, also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest. This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. In humans, Cdk1 is encoded by the CDC2 gene. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates ; phosphorylation of these proteins leads to cell cycle progression.

Cyclin-dependent kinase inhibitor 1B (p27^Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.

G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene.

G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in dividing somatic cells.

Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.

Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.

Cyclin-dependent kinases regulatory subunit 1 is a protein that in humans is encoded by the CKS1B gene.

Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.

Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene.

Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138764 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.
1 2 "Entrez Gene: CCNG2 cyclin G2".
↑ Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (Jul 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi: 10.1074/jbc.M111693200 . PMID 11956189.

External links

Human CCNG2 genome location and CCNG2 gene details page in the UCSC Genome Browser .

Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF (1996). "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression". J. Biol. Chem. 271 (11): 6050–61. doi: 10.1074/jbc.271.11.6050 . PMID 8626390.
Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi: 10.1074/jbc.M111693200 . PMID 11956189.
Tian YL, Liu FR, Liu J, Jiang L, Luo Y, Zhang X (2002). "[Ectopic expression of cyclin G2 inhibits cell proliferation in HeLa cancer cell line]". AI Zheng. 21 (6): 577–81. PMID 12452053.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Bergqvist M, Brattström D, Brodin D, Lindkvist A, Dahlman-Wright K, Dreilich M, Wagenius G, Paulsson-Karlsson Y (2006). "Genes associated with telomerase activity levels in esophageal carcinoma cell lines". Diseases of the Esophagus. 19 (1): 20–3. doi:10.1111/j.1442-2050.2006.00532.x. PMID 16364039.
Stossi F, Likhite VS, Katzenellenbogen JA, Katzenellenbogen BS (2006). "Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter". J. Biol. Chem. 281 (24): 16272–8. doi: 10.1074/jbc.M513405200 . PMID 16608856.
Arachchige Don AS, Dallapiazza RF, Bennin DA, Brake T, Cowan CE, Horne MC (2006). "Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest". Exp. Cell Res. 312 (20): 4181–204. doi:10.1016/j.yexcr.2006.09.023. PMC 1862360 . PMID 17123511.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138764 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8806701-4] Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.

[entrez-5] 1 2 "Entrez Gene: CCNG2 cyclin G2".

[pmid11956189-6] Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (Jul 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi: 10.1074/jbc.M111693200 . PMID 11956189.

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