CCNG2

CCNG2
Identifiers
Aliases	CCNG2 , cyclin G2
External IDs	OMIM: 603203; MGI: 1095734; HomoloGene: 3208; GeneCards: CCNG2; OMA:CCNG2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q21.1 Start 77,157,207 bp [1] End 77,433,388 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 E2 Start 93,415,116 bp [2] End 93,424,090 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid germinal epithelium parietal pleura tibia visceral pleura oral cavity cerebellar vermis epithelium of nasopharynx Brodmann area 23 lactiferous duct Top expressed in medial ganglionic eminence saccule left colon jejunum thymus decidua superior cervical ganglion otic vesicle ileum dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding Cellular component cytoplasm cyclin-dependent protein kinase holoenzyme complex nucleus Biological process cell cycle regulation of cell cycle cell division regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle protein phosphorylation regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 901 12452 Ensembl ENSG00000138764 ENSMUSG00000029385 UniProt Q16589 O08918 RefSeq (mRNA) NM_004354 NM_007635 RefSeq (protein) NP_004345 NP_031661 Location (UCSC) Chr 4: 77.16 – 77.43 Mb Chr 5: 93.42 – 93.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene. ^{[5] [6]}

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. ^[6]

Interactions

CCNG2 has been shown to interact with PPP2CA. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138764 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029385 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID   8806701.
6. "Entrez Gene: CCNG2 cyclin G2".
7. Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (Jul 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi: 10.1074/jbc.M111693200 . PMID   11956189.

External links

• Human CCNG2 genome location and CCNG2 gene details page in the UCSC Genome Browser .

Further reading

• Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF (1996). "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression". J. Biol. Chem. 271 (11): 6050–61. doi: 10.1074/jbc.271.11.6050 . PMID   8626390.
• Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi: 10.1074/jbc.M111693200 . PMID   11956189.
• Tian YL, Liu FR, Liu J, Jiang L, Luo Y, Zhang X (2002). "[Ectopic expression of cyclin G2 inhibits cell proliferation in HeLa cancer cell line]". AI Zheng. 21 (6): 577–81. PMID   12452053.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Bergqvist M, Brattström D, Brodin D, Lindkvist A, Dahlman-Wright K, Dreilich M, Wagenius G, Paulsson-Karlsson Y (2006). "Genes associated with telomerase activity levels in esophageal carcinoma cell lines". Diseases of the Esophagus. 19 (1): 20–3. doi: 10.1111/j.1442-2050.2006.00532.x . PMID   16364039.
• Stossi F, Likhite VS, Katzenellenbogen JA, Katzenellenbogen BS (2006). "Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter". J. Biol. Chem. 281 (24): 16272–8. doi: 10.1074/jbc.M513405200 . PMID   16608856.
• Arachchige Don AS, Dallapiazza RF, Bennin DA, Brake T, Cowan CE, Horne MC (2006). "Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest". Exp. Cell Res. 312 (20): 4181–204. doi:10.1016/j.yexcr.2006.09.023. PMC   1862360 . PMID   17123511.