CD2BP2

CD2BP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GYF, 1L2Z, 1SYX, 4BWS
Identifiers
Aliases	CD2BP2 , FWP010, LIN1, PPP1R59, Snu40, U5-52K, CD2 (cytoplasmic tail) binding protein 2, CD2 cytoplasmic tail binding protein 2
External IDs	OMIM: 604470 MGI: 1917483 HomoloGene: 4455 GeneCards: CD2BP2
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,355,308 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,795,222 bp
RNA expression pattern
	Top expressed in
	Left adrenal gland; ; Right adrenal gland; ; islet of Langerhans; ; left uterine tube; ; gastric mucosa; ; monocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of stomach; ; body of pancreas;
	Top expressed in
	saccule; ; otic placode; ; ganglionic eminence; ; superior cervical ganglion; ; yolk sac; ; primitive streak; ; lip; ; vas deferens; ; thymus; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ribonucleoprotein complex binding ; protein binding ;
Cellular component	U5 snRNP ; nuclear speck ; U4/U6 x U5 tri-snRNP complex ; nucleus ; nucleoplasm ; fibrillar center ; cytoplasm ; cytosol ;
Biological process	negative regulation of phosphatase activity ; mRNA splicing, via spliceosome ; mRNA processing ; spliceosomal tri-snRNP complex assembly ; RNA splicing ;
	Sources:Amigo / QuickGO
Orthologs
	10421
	70233
	ENSG00000169217
	ENSMUSG00000042502
	O95400
	Q9CWK3
	NM_006110 ; NM_001243646
	NM_001285905 ; NM_001285906 ; NM_001285907 ; NM_027353 ; NM_001357817 Contents Interactions ; References ; Further reading ; External links ;
	NP_001230575 ; NP_006101 ; NP_001230575.1 ; NP_006101.1
	NP_001272834 ; NP_001272835 ; NP_001272836 ; NP_081629 ; NP_001344746
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

CD2 antigen cytoplasmic tail-binding protein 2 is a protein that in humans is encoded by the CD2BP2 gene.^[5]^[6]

Interactions

CD2BP2 has been shown to interact with CD2.^[5]

Related Research Articles

Small nuclear ribonucleoprotein-associated protein N is a protein that in humans is encoded by the SNRPN gene.

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

Pinin is a protein that in humans is encoded by the PNN gene.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

Nucleolar protein 58 is a protein that in humans is encoded by the NOP58 gene.

H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene.

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.

RNA-binding protein 28 is a protein that in humans is encoded by the RBM28 gene. It is a nucleolar component of the spliceosomal ribonucleoprotein complexes.

WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene.

Zinc finger protein 473 is a protein that in humans is encoded by the ZNF473 gene.

In molecular biology, the GYF domain is an approximately 60-amino acid protein domain which contains a conserved GP[YF]xxxx[MV]xxWxxx[GN]YF motif. It was identified in the human intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two tandem PPPGHR segments within the cytoplasmic region of CD2. Binding experiments and mutational analyses have demonstrated the critical importance of the GYF tripeptide in ligand binding. A GYF domain is also found in several other eukaryotic proteins of unknown function. It has been proposed that the GYF domain found in these proteins could also be involved in proline-rich sequence recognition. Resolution of the structure of the CD2BP2 GYF domain by NMR spectroscopy revealed a compact domain with a beta-beta-alpha-beta-beta topology, where the single alpha-helix is tilted away from the twisted, anti-parallel beta-sheet. The conserved residues of the GYF domain create a contiguous patch of predominantly hydrophobic nature which forms an integral part of the ligand-binding site. There is limited homology within the C-terminal 20-30 amino acids of various GYF domains, supporting the idea that this part of the domain is structurally but not functionally important.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169217 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042502 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (Jan 1999). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc Natl Acad Sci U S A. 95 (25): 14897–902. doi: 10.1073/pnas.95.25.14897 . PMC 24547 . PMID 9843987.
↑ "Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2".

External links

Human CD2BP2 genome location and CD2BP2 gene details page in the UCSC Genome Browser .

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169217 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042502 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9843987-5] 1 2 Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (Jan 1999). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc Natl Acad Sci U S A. 95 (25): 14897–902. doi: 10.1073/pnas.95.25.14897 . PMC 24547 . PMID 9843987.

[entrez-6] "Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2".

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CD2BP2

Contents

Interactions

Related Research Articles

References

Further reading

External links