CDC40

CDC40
Identifiers
Aliases	CDC40 , EHB3, PRP17, PRPF17, cell division cycle 40, PCH15
External IDs	OMIM: 605585 MGI: 1918963 HomoloGene: 5716 GeneCards: CDC40
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q21 Start 110,180,141 bp [1] End 110,254,275 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 B1 Start 40,707,617 bp [2] End 40,759,307 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus sperm Achilles tendon monocyte secondary oocyte bone marrow deltoid muscle parietal pleura palpebral conjunctiva Brodmann area 23 Top expressed in hand otolith organ utricle interventricular septum Paneth cell secondary oocyte superior cervical ganglion olfactory tubercle medial ganglionic eminence Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex nucleoplasm nucleus U2-type catalytic step 2 spliceosome nuclear speck Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA export from nucleus mRNA 3'-end processing RNA splicing RNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51362 71713 Ensembl ENSG00000168438 ENSMUSG00000038446 UniProt O60508 Q9DC48 RefSeq (mRNA) NM_015891 NM_027879 RefSeq (protein) NP_056975 NP_082155 Location (UCSC) Chr 6: 110.18 – 110.25 Mb Chr 10: 40.71 – 40.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene. ^{[5] [6] [7]}

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000168438 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038446 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M (Oct 1998). "Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control". RNA. 4 (10): 1304–12. doi:10.1017/S1355838298980712. PMC   1369702 . PMID   9769104.
6. Lindsey LA, Garcia-Blanco MA (Jan 1999). "Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p". J Biol Chem. 273 (49): 32771–5. doi: 10.1074/jbc.273.49.32771 . PMID   9830021.
7. "Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)".

External links

• Human CDC40 genome location and CDC40 gene details page in the UCSC Genome Browser .

Further reading

• Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. Bibcode:1995PNAS...92.9530W. doi: 10.1073/pnas.92.21.9530 . PMC   40835 . PMID   7568168.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC   275390 . PMID   9303539.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhou Z, Reed R (1998). "Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing". EMBO J. 17 (7): 2095–106. doi:10.1093/emboj/17.7.2095. PMC   1170554 . PMID   9524131.
• Ben-Yehuda S, Dix I, Russell CS, et al. (2001). "Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae". Genetics. 156 (4): 1503–17. doi:10.1093/genetics/156.4.1503. PMC   1461362 . PMID   11102353.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.