CDC42EP4

Last updated
CDC42EP4
Identifiers
Aliases CDC42EP4 , BORG4, CEP4, KAIA1777, CDC42 effector protein 4
External IDs OMIM: 605468; MGI: 1929760; HomoloGene: 8110; GeneCards: CDC42EP4; OMA:CDC42EP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012121

NM_001163346
NM_020006

RefSeq (protein)

NP_036253

NP_001156818
NP_064390

Location (UCSC) Chr 17: 73.28 – 73.31 Mb Chr 11: 113.62 – 113.64 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene. [5] [6] [7]

Contents

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [7]

Related Research Articles

The Rho family of GTPases is a family of small signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions.

<span class="mw-page-title-main">TRIP10</span> Protein-coding gene in the species Homo sapiens

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene.

<span class="mw-page-title-main">RHOQ</span> Protein-coding gene in the species Homo sapiens

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.

<span class="mw-page-title-main">CDC42BPA</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.

<span class="mw-page-title-main">CDC42EP3</span> Protein-coding gene in the species Homo sapiens

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

<span class="mw-page-title-main">CDC42EP1</span> Protein-coding gene in the species Homo sapiens

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

<span class="mw-page-title-main">CYFIP1</span> Protein-coding gene in the species Homo sapiens

Cytoplasmic FMR1-interacting protein 1 is a protein that in humans is encoded by the CYFIP1 gene.

<span class="mw-page-title-main">BNIP2</span> Protein-coding gene in the species Homo sapiens

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.

<span class="mw-page-title-main">FNBP1L</span> Protein-coding gene in the species Homo sapiens

Formin-binding protein 1-like is a protein that in humans is encoded by the FNBP1L gene.

<span class="mw-page-title-main">SRGAP3</span> Protein-coding gene in the species Homo sapiens

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

<span class="mw-page-title-main">SNX26</span> Protein-coding gene in the species Homo sapiens

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.

<span class="mw-page-title-main">TBC1D3</span> Protein-coding gene in the species Homo sapiens

TBC1 domain family member 3E/3F is a protein that in humans is encoded by the TBC1D3F gene.

<span class="mw-page-title-main">DAAM1</span> Protein-coding gene in the species Homo sapiens

Dishevelled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

<span class="mw-page-title-main">CDC42EP2</span> Protein-coding gene in the species Homo sapiens

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.

<span class="mw-page-title-main">FGD4</span> Protein-coding gene in humans

FYVE, RhoGEF and PH domain-containing protein 4 is a protein encoded in humans by the FGD4 gene.

<span class="mw-page-title-main">RHOBTB1</span> Protein-coding gene in the species Homo sapiens

Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.

<span class="mw-page-title-main">Dedicator of cytokinesis protein 9</span> Protein found in humans

Dedicator of cytokinesis protein 9 (Dock9), also known as Zizimin1, is a large protein encoded in the human by the DOCK9 gene, involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors that function as activators of small G-proteins. Dock9 activates the small G protein Cdc42.

<span class="mw-page-title-main">RHOJ</span> Protein-coding gene in the species Homo sapiens

Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.

<span class="mw-page-title-main">FGD2</span> Protein-coding gene in the species Homo sapiens

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

<span class="mw-page-title-main">ARHGAP31</span> Protein-coding gene in the species Homo sapiens

The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000179604 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041598 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi: 10.1074/jbc.M007039200 . PMID   11035016.
  6. Joberty G, Perlungher RR, Macara IG (Feb 2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol Cell Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC   84628 . PMID   10490598.
  7. 1 2 "Entrez Gene: CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4".

Further reading