CDCA8

CDCA8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KDD, 2QFA, 2RAW, 2RAX
Identifiers
Aliases	CDCA8 , BOR, BOREALIN, DasraB, MESRGP, cell division cycle associated 8
External IDs	OMIM: 609977 MGI: 1196274 HomoloGene: 23075 GeneCards: CDCA8
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,709,719 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,833,104 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; embryo; ; ganglionic eminence; ; rectum; ; bone marrow; ; stromal cell of endometrium; ; spongy bone; ; appendix; ; bone marrow cells;
	Top expressed in
	Paneth cell; ; renal corpuscle; ; condyle; ; primitive streak; ; fossa; ; ureter; ; medullary collecting duct; ; endocardial cushion; ; secondary oocyte; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	intercellular bridge ; nucleolus ; nucleoplasm ; cytoplasm ; spindle ; chromosome ; cytosol ; nucleus ; chromosome, centromeric region ; chromocenter ; midbody ; chromosome passenger complex ; spindle midzone ; cytoskeleton ; protein-containing complex ;
Biological process	chromosome organization ; cell cycle ; cell division ; mitotic metaphase plate congression ; mitotic sister chromatid segregation ;
	Sources:Amigo / QuickGO
Orthologs
	55143
	52276
	ENSG00000134690
	ENSMUSG00000028873
	Q53HL2
	Q8BHX3
	NM_018101 ; NM_001256875
	NM_026560
	NP_001243804 ; NP_060571
	NP_080836
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 29, 2023

Borealin is a protein that in humans is encoded by the CDCA8 gene.^[5]^[6]^[7]

Function

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.^[7]^[8]

Interactions

CDCA8 has been shown to interact with INCENP,^[8] Survivin ^[6]^[8] and Aurora B kinase.^[6]^[8]

Related Research Articles

Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere.

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.

Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 is an enzyme that in humans is encoded by the BUB1 gene.

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.

Inner centromere protein is a protein that in humans is encoded by the INCENP gene. It is a regulatory protein in the chromosome passenger complex (CPC). It is involved in regulation of the catalytic proteins Aurora B and Aurora C. It acts in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N-terminal domain of INCENP is the domain involved in formation of this three-helical bundle while its C-terminal domain is responsible for the interaction with Aurora B.

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.

<span class="mw-page-title-main">KIF4A</span> Protein-coding gene in the species Homo sapiens

Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.

Centromere protein U is a protein that in humans is encoded by the CENPU gene.

Aurora kinase C, also Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene.

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

<span class="mw-page-title-main">KIFC1</span> Protein-coding gene in the species Homo sapiens

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.

Condensin complex subunit 3 also known as condensin subunit CAP-G (CAP-G) or non-SMC condensin I complex subunit G (NCAPG) is a protein that in humans is encoded by the NCAPG gene. CAP-G is a subunit of condensin I, a large protein complex involved in chromosome condensation.

Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene. CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.

Ecotropic viral integration site 5 protein homolog is a protein that in humans is encoded by the EVI5 gene.

MIS18 binding protein 1 is a protein that in humans is encoded by the MIS18BP1 gene. The gene is also known as LKNL2, M18BP1, C14orf106, and HSA242977.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134690 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028873 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets . 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
1 2 3 Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi: 10.1016/j.cell.2004.06.026 . PMID 15260989.
1 2 "Entrez Gene: CDCA8 cell division cycle associated 8".
1 2 3 4 Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304 . PMID 15249581.

External links

Human CDCA8 genome location and CDCA8 gene details page in the UCSC Genome Browser .

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134690 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028873 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12188893-5] Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets . 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.

[Sampath_2004-6] 1 2 3 Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi: 10.1016/j.cell.2004.06.026 . PMID 15260989.

[entrez-7] 1 2 "Entrez Gene: CDCA8 cell division cycle associated 8".

[Gassman_2004-8] 1 2 3 4 Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304 . PMID 15249581.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]