CDR2 (gene)

Not to be confused with Mitosis inducer protein kinase cdr2.

CDR2
Identifiers
Aliases	CDR2 , CDR62, Yo, cerebellar degeneration related protein 2
External IDs	OMIM: 117340; MGI: 1100885; HomoloGene: 7262; GeneCards: CDR2; OMA:CDR2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p12.2 Start 22,345,936 bp [1] End 22,437,165 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 F2|7 65.04 cM Start 120,556,259 bp [2] End 120,581,535 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte retinal pigment epithelium jejunal mucosa Epithelium of choroid plexus Achilles tendon sperm cartilage tissue left lobe of thyroid gland right lobe of thyroid gland gastric mucosa Top expressed in blood fetal liver hematopoietic progenitor cell saccule retinal pigment epithelium tibiofemoral joint otic placode neural layer of retina zygote otic vesicle human fetus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 1039 12585 Ensembl ENSG00000140743 ENSMUSG00000030878 UniProt Q01850 P97817 RefSeq (mRNA) NM_001802 NM_007672 NM_001354986 RefSeq (protein) NP_001793 NP_031698 NP_001341915 Location (UCSC) Chr 16: 22.35 – 22.44 Mb Chr 7: 120.56 – 120.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cerebellar degeneration-related protein 2 is a protein that in humans is encoded by the CDR2 gene. ^{[5] [6]} It promotes cerebellar Purkinje cell survival through downregulation of c-Myc, indicating that CDR2 is a protooncogene. ^[7]

See also

• Cerebellar degeneration-related protein 1

References

1. GRCh38: Ensembl release 89: ENSG00000140743 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030878 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fathallah-Shaykh H, Wolf S, Wong E, Posner JB, Furneaux HM (May 1991). "Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration". Proc Natl Acad Sci U S A. 88 (8): 3451–4. Bibcode:1991PNAS...88.3451F. doi: 10.1073/pnas.88.8.3451 . PMC   51465 . PMID   2014264.
6. "Entrez Gene: CDR2 cerebellar degeneration-related protein 2, 62kDa".
7. Okano, H. J.; Park, W.-Y.; Corradi, J. P.; Darnell, R. B. (1999-08-15). "The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival". Genes & Development. 13 (16): 2087–2097. doi:10.1101/gad.13.16.2087. ISSN   0890-9369. PMC   316965 . PMID   10465786.

Further reading

• Gress T, Baldini A, Rocchi M, et al. (1992). "In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1". Genomics. 13 (4): 1340–2. doi:10.1016/0888-7543(92)90063-X. PMID   1505970.
• Sakai K, Mitchell DJ, Tsukamoto T, Steinman L (1992). "Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration". Ann. Neurol. 30 (5): 738. doi: 10.1002/ana.410300523 . PMID   1763903.
• Sakai K, Mitchell DJ, Tsukamoto T, Steinman L (1991). "Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration". Ann. Neurol. 28 (5): 692–8. doi:10.1002/ana.410280515. PMID   2260856. S2CID   28532317.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Fletcher CF, Okano HJ, Gilbert DJ, et al. (1998). "Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens". Genomics. 45 (2): 313–9. doi:10.1006/geno.1997.4925. PMID   9344654.
• Takanaga H, Mukai H, Shibata H, et al. (1998). "PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor". Exp. Cell Res. 241 (2): 363–72. doi:10.1006/excr.1998.4060. PMID   9637778.
• Okano HJ, Park WY, Corradi JP, Darnell RB (1999). "The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival". Genes Dev. 13 (16): 2087–97. doi:10.1101/gad.13.16.2087. PMC   316965 . PMID   10465786.
• Sakai K, Shirakawa T, Li Y, et al. (2002). "Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X.". Mol. Cell. Neurosci. 19 (4): 477–84. doi:10.1006/mcne.2001.1059. PMID   11988016. S2CID   26659745.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sutton IJ, Steele J, Savage CO, et al. (2004). "An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies". J. Neuroimmunol. 150 (1–2): 98–106. doi:10.1016/j.jneuroim.2003.12.026. PMID   15081253. S2CID   45697226.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Balbo M, Barel M, Lottin-Divoux S, et al. (2005). "Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)". FEMS Microbiol. Lett. 249 (2): 359–66. doi: 10.1016/j.femsle.2005.06.052 . PMID   16054780.

External links

• CDR2 human gene location in the UCSC Genome Browser .
• CDR2 human gene details in the UCSC Genome Browser .