CENPL

CENPL
Identifiers
Aliases	CENPL , C1orf155, CENP-L, dJ383J4.3, centromere protein L
External IDs	OMIM: 611503 MGI: 1917704 HomoloGene: 19618 GeneCards: CENPL
Gene location (Human)
Chr.	Chromosome 1 (human)
End	173,824,720 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,914,294 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ganglionic eminence; ; endothelial cell; ; bone marrow; ; stromal cell of endometrium; ; bone marrow cells; ; Achilles tendon; ; cancellous bone; ; appendix;
	Top expressed in
	hand; ; medial ganglionic eminence; ; thymus; ; endocardial cushion; ; ankle joint; ; morula; ; bone marrow; ; abdominal wall; ; seminiferous tubule; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	chromosome ; cytosol ; chromosome, centromeric region ; nucleus ; nucleoplasm ;
Biological process	CENP-A containing chromatin assembly ;
	Sources:Amigo / QuickGO
Orthologs
	91687
	70454
	ENSG00000120334
	ENSMUSG00000026708
	Q8N0S6
	Q3U3S3
	NM_033319 ; NM_001127181 ; NM_001171182
	NM_001159930 ; NM_027429
	NP_001120653 ; NP_001164653 ; NP_201576
	NP_001153402
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 13, 2023

Centromere protein L is a protein that in humans is encoded by the CENPL gene.^[5]^[6]^[7]

Related Research Articles

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome in most eukaryotes including humans.

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.

Centromere protein U is a protein that in humans is encoded by the CENPU gene.

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.

Shugoshin 2(Shugoshin-2), also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.

Zinc finger CCCH domain-containing protein 13 is a protein that in humans is encoded by the ZC3H13 gene.

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.

Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.

Centromere protein T is a protein that in humans is encoded by the CENPT gene.

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.

Centromere protein N is a protein that in humans is encoded by the CENPN gene.

Centromere protein K is a protein that in humans is encoded by the CENPK gene.

DSN1, MIND kinetochore complex component, homolog , also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120334 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026708 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
↑ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
↑ "Entrez Gene: CENPL centromere protein L".

External links

Human CENPL genome location and CENPL gene details page in the UCSC Genome Browser .

Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID 16716197.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID 15009096. S2CID 21813024.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

This protein-related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000120334 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026708 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16622420-5] Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.

[pmid16622419-6] Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.

[entrez-7] "Entrez Gene: CENPL centromere protein L".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

CENPL

Contents

Related Research Articles

References

External links

Further reading