CENPL

CENPL
Identifiers
Aliases	CENPL , C1orf155, CENP-L, dJ383J4.3, centromere protein L
External IDs	OMIM: 611503; MGI: 1917704; HomoloGene: 19618; GeneCards: CENPL; OMA:CENPL - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q25.1 Start 173,799,550 bp [1] End 173,824,720 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H2.1 Start 160,898,283 bp [2] End 160,914,294 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ventricular zone secondary oocyte gonad ganglionic eminence testicle endothelial cell bone marrow stromal cell of endometrium bone marrow cells Top expressed in hand medial ganglionic eminence genital tubercle thymus ventricular zone granulocyte tail of embryo epiblast embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component chromosome cytosol chromosome, centromeric region nucleus nucleoplasm Biological process CENP-A containing chromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91687 70454 Ensembl ENSG00000120334 ENSMUSG00000026708 UniProt Q8N0S6 Q3U3S3 RefSeq (mRNA) NM_033319 NM_001127181 NM_001171182 NM_001159930 NM_027429 RefSeq (protein) NP_001120653 NP_001164653 NP_201576 NP_001153402 Location (UCSC) Chr 1: 173.8 – 173.82 Mb Chr 1: 160.9 – 160.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein L is a protein that in humans is encoded by the CENPL gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000120334 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026708 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID   16622420. S2CID   26974412.
6. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID   16622419. S2CID   205286556.
7. "Entrez Gene: CENPL centromere protein L".

External links

• Human CENPL genome location and CENPL gene details page in the UCSC Genome Browser .

Further reading

• Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID   16716197.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID   15009096. S2CID   21813024.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.