CENPN

CENPN
Identifiers
Aliases	CENPN , BM039, C16orf60, CENP-N, ICEN32, centromere protein N
External IDs	OMIM: 611509 MGI: 1919405 HomoloGene: 12450 GeneCards: CENPN
Gene location (Human)
Chr.	Chromosome 16 (human)
End	81,033,114 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	117,668,246 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; secondary oocyte; ; bone marrow; ; stromal cell of endometrium; ; sperm; ; cancellous bone; ; bone marrow cells; ; prostate; ; testicle; ; amniotic fluid;
	Top expressed in
	secondary oocyte; ; seminiferous tubule; ; spermatid; ; spermatocyte; ; yolk sac; ; primitive streak; ; blastocyst; ; morula; ; maxillary prominence; ; otic placode;
	More reference expression data
	; ;
	More reference expression data
Orthologs
	55839
	72155
	ENSG00000166451
	ENSMUSG00000031756
	Q96H22
	Q9CZW2
	NM_001100624 ; NM_001100625 ; NM_001270473 ; NM_001270474 ; NM_018455 Contents References ; External links ; Further reading ;
	NM_028131
	NP_001094094 ; NP_001094095 ; NP_001257402 ; NP_001257403 ; NP_060925
	NP_082407
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Centromere protein N is a protein that in humans is encoded by the CENPN gene.^[5]^[6]

Related Research Articles

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome in most eukaryotes including humans.

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.

Centromere protein U is a protein that in humans is encoded by the CENPU gene.

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

Centromere protein H is a protein that in humans is encoded by the CENPH gene.

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.

Shugoshin-like 2 , also known as SGOL2, is a protein which in humans is encoded by the SGOL2 gene.

Zinc finger CCCH domain-containing protein 13 is a protein that in humans is encoded by the ZC3H13 gene.

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.

Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.

Centromere protein T is a protein that in humans is encoded by the CENPT gene.

WP:SE

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.

Centromere protein K is a protein that in humans is encoded by the CENPK gene.

Centromere protein L is a protein that in humans is encoded by the CENPL gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166451 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031756 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
↑ "Entrez Gene: CENPN centromere protein N".

External links

Human CENPN genome location and CENPN gene details page in the UCSC Genome Browser .

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID 16716197. S2CID 45931410.
Okada M, Cheeseman IM, Hori T, et al. (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat. Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166451 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031756 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16622419-5] Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.

[entrez-6] "Entrez Gene: CENPN centromere protein N".

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CENPN

Contents

Related Research Articles

References

External links

Further reading