CENTG1

AGAP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BMJ, 2IWR, 2RLO
Identifiers
Aliases	AGAP2 , CENTG1, GGAP2, PIKE, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
External IDs	OMIM: 605476 MGI: 3580016 HomoloGene: 86815 GeneCards: AGAP2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,742,157 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	126,929,038 bp
RNA expression pattern
	Top expressed in
	cingulate gyrus; ; nucleus accumbens; ; amygdala; ; prefrontal cortex; ; caudate nucleus; ; Brodmann area 9; ; putamen; ; frontal pole; ; middle frontal gyrus; ; hippocampus proper;
	Top expressed in
	superior frontal gyrus; ; hippocampus proper; ; olfactory bulb; ; cerebellar cortex; ; hypothalamus; ; thymus; ; spleen; ; ganglionic eminence; ; bone marrow; ; uterus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity ; metal ion binding ; nucleotide binding ; GTP binding ; protein binding ; GTPase activity ;
Cellular component	extracellular exosome ; membrane ; nucleolus ; cytoplasm ; mitochondrion ; nucleus ;
Biological process	negative regulation of neuron apoptotic process ; protein transport ; negative regulation of protein catabolic process ; positive regulation of GTPase activity ; transport ; positive regulation of 1-phosphatidylinositol-3-kinase activity ;
	Sources:Amigo / QuickGO
Orthologs
	116986
	216439
	ENSG00000135439
	ENSMUSG00000025422
	Q99490
	Q3UHD9
	NM_001122772 ; NM_014770
	NM_001033263 ; NM_001301014
	NP_001116244 ; NP_055585
	NP_001028435 ; NP_001287943
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.^[5]

Interactions

CENTG1 has been shown to interact with:

Related Research Articles

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Lewis C. Cantley is an American cell biologist and biochemist who has made significant advances to the understanding of cancer metabolism. Among his most notable contributions are the discovery and study of the enzyme PI-3-kinase, now known to be important to understanding cancer and diabetes mellitus. He is currently Meyer Director and Professor of Cancer Biology at the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine in New York City. He was formerly a professor in the Departments of Systems Biology and Medicine at Harvard Medical School, and the Director of Cancer Research at the Beth Israel Deaconess Medical Center, in Boston, Massachusetts. In 2016, he was elected Chairman of the Board for the Hope Funds for Cancer Research.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135439 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025422 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CENTG1 centaurin, gamma 1".
1 2 Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi: 10.1016/S0092-8674(00)00195-1 . PMID 11136977. S2CID 16610638.
↑ Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.

External links

Human AGAP2 genome location and AGAP2 gene details page in the UCSC Genome Browser .

Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi: 10.1093/dnares/3.1.17 . PMID 8724849.
Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi: 10.1016/S0092-8674(00)00195-1 . PMID 11136977. S2CID 16610638.
Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH (2002). "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE". Nature. 415 (6871): 541–4. doi:10.1038/415541a. PMID 11823862. S2CID 4371421.
Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA (2003). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". J. Biol. Chem. 277 (50): 48965–75. doi: 10.1074/jbc.M202969200 . PMID 12388557.
Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–88. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724 . PMID 12640130.
Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.
Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K (2004). "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion". J. Biol. Chem. 279 (16): 16441–51. doi: 10.1074/jbc.M312175200 . PMID 14761976.
Ahn JY, Hu Y, Kroll TG, Allard P, Ye K (2004). "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6993–8. Bibcode:2004PNAS..101.6993A. doi: 10.1073/pnas.0400921101 . PMC 406454 . PMID 15118108.
Nie Z, Fei J, Premont RT, Randazzo PA (2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3". J. Cell Sci. 118 (Pt 15): 3555–66. doi: 10.1242/jcs.02486 . PMID 16079295.
Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas". Neuropathol. Appl. Neurobiol. 31 (5): 486–90. doi:10.1111/j.1365-2990.2005.00660.x. PMID 16150119. S2CID 21766234.
Hu Y, Liu Z, Ye K (2006). "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853–8. doi: 10.1073/pnas.0507365102 . PMC 1283830 . PMID 16263930.
Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival". Cell Death Differ. 14 (2): 368–77. doi: 10.1038/sj.cdd.4402011 . PMID 16841086.
Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA (2007). "The centaurin gamma-1 GTPase-like domain functions as an NTPase". Biochem. J. 401 (3): 679–88. doi:10.1042/BJ20060555. PMC 1770848 . PMID 17037982.
Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A". J. Virol. 81 (5): 2340–8. doi:10.1128/JVI.01310-06. PMC 1865929 . PMID 17151107.
Liu X, Hu Y, Hao C, Rempel SA, Ye K (2007). "PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion". Oncogene. 26 (34): 4918–27. doi:10.1038/sj.onc.1210290. PMID 17297440. S2CID 1156814.
Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2". Traffic. 8 (6): 661–72. doi: 10.1111/j.1600-0854.2007.00561.x . PMID 17461797. S2CID 28218061.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135439 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025422 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CENTG1 centaurin, gamma 1".

[pmid11136977-6] 1 2 Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi: 10.1016/S0092-8674(00)00195-1 . PMID 11136977. S2CID 16610638.

[pmid14528310-7] Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.

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CENTG1

Contents

Interactions

Related Research Articles

References

External links

Further reading