CFAP157 | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CFAP157 , C9orf117, cilia and flagella associated protein 157 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 2447809 HomoloGene: 53056 GeneCards: CFAP157 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Cilia and flagella associated protein 157 (CFAP157) also known as chromosome 9 open reading frame 117 (c9orf117) is a protein that in humans is encoded by the CFAP157 gene.
CFAP157 gene is "specifically required during spermatogenesis for flagellum morphogenesis and sperm motility and may be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure," [4] according to UniProt.
CFAP157 is located on chromosome 9, 9q34.11 in human from base pair 127,706,989 to base pair 127,716,002. [5]
The size of the gene is 9,013 bases, and the orientation is plus strand. [5] The gene holds 9 exons. [6]
The most common variant of mRNAs of CFAP157 contains 1,722 base pairs. [6]
CFAP157 is expressed in many human body tissues such as cervix, lung, testis, and uterus. People who have uterine tumor are likely to have an expression in CFAP157. This gene is expressed in both adults and fetuses. [7]
There are 520 amino acids in CFAP157 in human. [8] The protein is glutamine extremely rich, and glycine poor. The protein is quite neutral with the isoelectric point at pH 7.4. [9] The average mass of the protein is estimated to be 60,531.748 Da, and the absorption coefficient is estimated to be 25,440 M−1 cm−1.
CFAP157 is primarily composed of α-helices, and there is no transmembrane helix. The protein structure making program called Phyre is used to create the predicted structure of CFAP157.
There is no known paralog for CFAP157 in human. CFAP157 has numerous orthologs. The following table contains some of orthologs including human, common chimpanzee, rhesus macaque, cattle, dog, mouse, rat, tropical clawed frog, and zebra fish. [10]
Species | Common Name | Accession Number | Sequence Identity | Sequence Similarity |
---|---|---|---|---|
Homo sapiens | Human | NP_001012520 | 100% | 100% |
Pan troglodytes | Common chimpanzee | XP_001143084 | 98.5% | 99.0% |
Macaca mulatta | Rhesus macaque | XP_001095281 | 95.2% | 96.4% |
Bos taurus | Cattle | XP_005213477 | 70.5% | 84.0% |
Canis lupus familiaris | Dog | XP_005625392 | 71.5% | 80.9% |
Mus musculus | Mouse | NP_079895 | 64.6% | 79.0% |
Rattus norvegicus | Rat | NP_001094339 | 64.2% | 78.4% |
Xenopus tropicalis | Tropical clawed frog | NP_001072774 | 41.5% | 60.5% |
Danio rerio | Zebrafish | NP_001103638 | 34.0% | 54.9% |
P14335 (Kunjin virus strain MRM61C) is the virus that interacts with CFAP157 via two-hybrid screening. Kunjin virus is not as severe as other viruses, but this is a noticeable discovery because it is possible to exploit the interaction to develop new types of medicine. Researchers at the University of Queensland discovered a new medical use for the Kunjin virus in 2005, and the possible treatments include HIV/cancer vaccines. [11]
TSR3, or TSR3 Ribosome Maturation Factor, is a hypothetical human protein found on chromosome 16. Its protein is 312 amino acids long. and its cDNA has 1214 base pairs It was previously designated C16orf42.
METTL26, previously designated C16orf13, is a protein-coding gene for Methyltransferase Like 26, also known as JFP2. Though the function of this gene is unknown, various data have revealed that it is expressed at high levels in various cancerous tissues. Underexpression of this gene has also been linked to disease consequences in humans.
Ankyrin repeat domain-containing protein 24 is a protein in humans that is coded for by the ANKRD24 gene. The gene is also known as KIAA1981. The protein's function in humans is currently unknown. ANKRD24 is in the protein family that contains ankyrin-repeat domains.
PRR29 is a protein encoded by the PRR29 gene located in humans on chromosome 17 at 17q23.
Transmembrane Protein 176B, or TMEM176B is a transmembrane protein that in humans is encoded by the TMEM176B gene. It is thought to play a role in the process of maturation of dendritic cells.
Chromosome 10 open reading frame 67 (C10orf67), also known as C10orf115, LINC01552, and BA215C7.4, is an un-characterized human protein-coding gene. Several studies indicate a possible link between genetic polymorphisms of this and several other genes to chronic inflammatory barrier diseases such as Crohn's Disease and sarcoidosis.
Transmembrane and coiled-coil domains 4, TMCO4, is a protein in humans that is encoded by the TMCO4 gene. Currently, its function is not well defined. It is transmembrane protein that is predicted to cross the endoplasmic reticulum membrane three times. TMCO4 interacts with other proteins known to play a role in cancer development, hinting at a possible role in the disease of cancer.
Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12), is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol.
Chromosome 16 open reading frame 46 is a protein of yet to be determined function in Homo sapiens. It is encoded by the C16orf46 gene with NCBI accession number of NM_001100873. It is a protein-coding gene with an overlapping locus.
Transmembrane protein 44 is a protein that in humans is encoded by the TMEM44 gene.
TMEM44 is a protein that in humans is encoded by the TMEM44 gene. DKFZp686O18124 is a synonym of TMEM44.
Chromosome 9 open reading frame 25 (C9orf25) is a domain that encodes the FAM219A gene. The terms FAM219A and C9orf25 are aliases and can be used interchangeably. The function of this gene is not yet completely understood.
Chromosome 19 open reading frame 44 is a protein that in humans is encoded by the C19orf44 gene. C19orf44 is an uncharacterized protein with an unknown function in humans. C19orf44 is non-limiting implying that the protein exists in other species besides human. The protein contains one domain of unknown function (DUF) that is highly conserved throughout its orthologs. This protein is most highly expressed in the testis and ovary, but also has significant expression in the thyroid and parathyroid. Other names for this protein include: LOC84167.
Cilia- and flagella-associated protein 299 (CFAP299), is a protein that in humans is encoded by the CFAP299 gene. CFAP299 is predicted to play a role in spermatogenesis and cell apoptosis.
Uncharacterized protein C17orf78 is a protein encoded by the C17orf78 gene in humans. The name denotes the location of the parent gene, being at the 78th open reading frame, on the 17th human chromosome. The protein is highly expressed in the small intestine, especially the duodenum. The function of C17orf78 is not well defined.
The FAM214B, also known as protein family with sequence similarity 214, B (FAM214B) is a protein that, in humans, is encoded by the FAM214B gene located on the human chromosome 9. The protein has 538 amino acids. The gene contain 9 exon. There has been studies that there are low expression of this gene in patients with major depression disorder. In most organisms such as mammals, amphibians, reptiles, and birds, there are high levels of gene expression in the bone marrow and blood. For humans in fetal development, FAM214B is mostly expressed in the brains and bone marrow.
C2orf72 is a gene in humans that encodes a protein currently named after its gene, C2orf72. It is also designated LOC257407 and can be found under GenBank accession code NM_001144994.2. The protein can be found under UniProt accession code A6NCS6.
THAP domain-containing protein 3 (THAP3) is a protein that, in Homo sapiens (humans), is encoded by the THAP3 gene. The THAP3 protein is as known as MGC33488, LOC90326, and THAP domain-containing, apoptosis associated protein 3. This protein contains the Thanatos-associated protein (THAP) domain and a host-cell factor 1C binding motif. These domains allow THAP3 to influence a variety of processes, including transcription and neuronal development. THAP3 is ubiquitously expressed in H. sapiens, though expression is highest in the kidneys.
Chromosome 5 Open Reading Frame 47, or C5ORF47, is a protein which, in humans, is encoded by the C5ORF47 gene. It also goes by the alias LOC133491. The human C5ORF47 gene is primarily expressed in the testis.
Secernin-3 (SCRN3) is a protein that is encoded by the human SCRN3 gene. SCRN3 belongs to the peptidase C69 family and the secernin subfamily. As a part of this family, the protein is predicted to enable cysteine-type exopeptidase activity and dipeptidase activity, as well as be involved in proteolysis. It is ubiquitously expressed in the brain, thyroid, and 25 other tissues. Additionally, SCRN3 is conserved in a variety of species, including mammals, birds, fish, amphibians, and invertebrates. SCRN3 is predicted to be an integral component of the cytoplasm.