CHST6

Last updated
CHST6
Identifiers
Aliases CHST6 , MCDC1, carbohydrate sulfotransferase 6, GST4-beta, gn6st-5, hCGn6ST, glcNAc6ST-5, C-GlcNAc6ST
External IDs OMIM: 605294 MGI: 1931825 HomoloGene: 56927 GeneCards: CHST6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021615

NM_019950

RefSeq (protein)

NP_067628

NP_064334

Location (UCSC) Chr 16: 75.47 – 75.5 Mb Chr 8: 112.62 – 112.64 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene. [5] [6] [7]

Contents

It codes for an enzyme necessary for the production of keratan sulfate. Mutations in the gene lead to macular corneal dystrophy.

Related Research Articles

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<span class="mw-page-title-main">Keratan sulfate</span> Class of chemical compounds

Keratan sulfate (KS), also called keratosulfate, is any of several sulfated glycosaminoglycans that have been found especially in the cornea, cartilage, and bone. It is also synthesized in the central nervous system where it participates both in development and in the glial scar formation following an injury. Keratan sulfates are large, highly hydrated molecules which in joints can act as a cushion to absorb mechanical shock.

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<span class="mw-page-title-main">GUCA1A</span> Protein-coding gene in the species Homo sapiens

Guanylyl cyclase-activating protein 1 is an enzyme that in humans is encoded by the GUCA1A gene.

<span class="mw-page-title-main">Keratocan</span>

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.

<span class="mw-page-title-main">Collagen, type VIII, alpha 2</span> Mammalian protein found in Homo sapiens

Collagen alpha-2(VIII) chain is a protein that in humans is encoded by the COL8A2 gene. Mutations of the gene are linked to posterior polymorphous dystrophy type 2.

<span class="mw-page-title-main">Cyclic nucleotide gated channel beta 3</span> Protein-coding gene in the species Homo sapiens

Cyclic nucleotide gated channel beta 3, also known as CNGB3, is a human gene encoding an ion channel protein.

<span class="mw-page-title-main">Collagen, type VIII, alpha 1</span>

Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene.

<span class="mw-page-title-main">CHST2</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

<span class="mw-page-title-main">CHST4</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

<span class="mw-page-title-main">VSX1</span> Protein-coding gene in the species Homo sapiens

Visual system homeobox 1 is a protein that in humans is encoded by the VSX1 gene.

<span class="mw-page-title-main">CHST1</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.

<span class="mw-page-title-main">CYP4V2</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 4V2 is a protein that in humans is encoded by the CYP4V2 gene.

<span class="mw-page-title-main">CHST5</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene.

<span class="mw-page-title-main">CHST11</span> Protein-coding gene in humans

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.

<span class="mw-page-title-main">CHST12</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

<span class="mw-page-title-main">CHST7</span> Protein-coding gene in humans

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

<span class="mw-page-title-main">CHST10</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

<span class="mw-page-title-main">Macular corneal dystrophy</span> Medical condition

Macular corneal dystrophy, also known as Fehr corneal dystrophy, is a rare pathological condition affecting the stroma of cornea first described by Arthur Groenouw in 1890. Signs are usually noticed in the first decade of life and progress afterwards, with opacities developing in the cornea and attacks of pain. This gradual opacification leads to visual impairment often requiring keratoplasty in the later decades of life.

<span class="mw-page-title-main">Carbohydrate sulfotransferase</span>

Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183196 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031952 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vance JM, Jonasson F, Lennon F, Sarrica J, Damji KF, Stauffer J, Pericak-Vance MA, Klintworth GK (Jul 1996). "Linkage of a gene for macular corneal dystrophy to chromosome 16". Am J Hum Genet. 58 (4): 757–62. PMC   1914688 . PMID   8644739.
  6. Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (Nov 2000). "Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene". Nat Genet. 26 (2): 237–41. doi:10.1038/79987. PMID   11017086. S2CID   25547752.
  7. "Entrez Gene: CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6".

Further reading