CIRBP

CIRBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X5S
Identifiers
Aliases	CIRBP , CIRP, cold inducible RNA binding protein
External IDs	OMIM: 602649 MGI: 893588 HomoloGene: 980 GeneCards: CIRBP
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,274,880 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,172,786 bp
RNA expression pattern
	Top expressed in
	tibia; ; corpus epididymis; ; caput epididymis; ; parietal pleura; ; germinal epithelium; ; right uterine tube; ; anterior pituitary; ; middle temporal gyrus; ; endothelial cell; ; palpebral conjunctiva;
	Top expressed in
	lip; ; cerebellar cortex; ; molar; ; spermatocyte; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; ganglionic eminence; ; entorhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	translation repressor activity ; nucleic acid binding ; protein binding ; small ribosomal subunit rRNA binding ; mRNA 3'-UTR binding ; RNA binding ; poly(U) RNA binding ;
Cellular component	cytoplasm ; cytoplasmic stress granule ; nucleolus ; nucleus ; nucleoplasm ; spliceosomal complex ; ribonucleoprotein complex ;
Biological process	stress granule assembly ; response to cold ; mRNA stabilization ; response to UV ; positive regulation of translation ; negative regulation of translation ; positive regulation of mRNA splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	1153
	12696
	ENSG00000099622
	ENSMUSG00000045193
	Q14011 ; Q53XX5
	P60824
	NM_001280 ; NM_001300815 ; NM_001300829
	NM_007705
	NP_001271 ; NP_001287744 ; NP_001287758 ; NP_001271.1
NP_031731 ; NP_001366350 ; NP_001366351 ; NP_001366352 ; NP_001366353 ;
	NP_001366354
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 17, 2024

Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene.^[5]^[6]^[7] The cold inducible RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, including short wavelength ultraviolet light, hypoxia, and hypothermia.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000099622 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045193 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nishiyama H, Higashitsuji H, Yokoi H, Itoh K, Danno S, Matsuda T, Fujita J (Feb 1998). "Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene". Gene. 204 (1–2): 115–20. doi:10.1016/S0378-1119(97)00530-1. PMID 9434172.
↑ Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J (Jun 1997). "A Glycine-rich RNA-binding Protein Mediating Cold-inducible Suppression of Mammalian Cell Growth". J Cell Biol. 137 (4): 899–908. doi:10.1083/jcb.137.4.899. PMC 2139845 . PMID 9151692.
↑ "Entrez Gene: CIRBP cold inducible RNA binding protein".

External links

Human CIRBP genome location and CIRBP gene details page in the UCSC Genome Browser .

Sheikh MS, Carrier F, Papathanasiou MA, et al. (1997). "Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein". J. Biol. Chem. 272 (42): 26720–6. doi: 10.1074/jbc.272.42.26720 . PMID 9334257.
Nishiyama H, Danno S, Kaneko Y, et al. (1998). "Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature". Am. J. Pathol. 152 (1): 289–96. PMC 1858111 . PMID 9422546.
Lee J, Bedford MT (2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays". EMBO Rep. 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. PMC 1084016 . PMID 11850402.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hamid AA, Mandai M, Fujita J, et al. (2004). "Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma". Int. J. Gynecol. Pathol. 22 (3): 240–7. doi:10.1097/01.PGP.0000070851.25718.EC. PMID 12819390. S2CID 22639276.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID 15057824.
Wellmann S, Bührer C, Moderegger E, et al. (2004). "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism". J. Cell Sci. 117 (Pt 9): 1785–94. doi: 10.1242/jcs.01026 . PMID 15075239.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000099622 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045193 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9434172-5] Nishiyama H, Higashitsuji H, Yokoi H, Itoh K, Danno S, Matsuda T, Fujita J (Feb 1998). "Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene". Gene. 204 (1–2): 115–20. doi:10.1016/S0378-1119(97)00530-1. PMID 9434172.

[pmid9151692-6] Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J (Jun 1997). "A Glycine-rich RNA-binding Protein Mediating Cold-inducible Suppression of Mammalian Cell Growth". J Cell Biol. 137 (4): 899–908. doi:10.1083/jcb.137.4.899. PMC 2139845 . PMID 9151692.

[entrez-7] "Entrez Gene: CIRBP cold inducible RNA binding protein".

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CIRBP

Contents

Related Research Articles

References

External links

Further reading