CKMT1B

CKMT1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QK1
Identifiers
Aliases	CKMT1B , CKMT, CKMT1, UMTCK, creatine kinase, mitochondrial 1B
External IDs	OMIM: 123290 MGI: 99441 HomoloGene: 69058 GeneCards: CKMT1B
Gene location (Human)
Chr.	Chromosome 15 (human)
End	43,604,901 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	121,194,218 bp
RNA expression pattern
	Top expressed in
	duodenum; ; rectum; ; superior frontal gyrus; ; Brodmann area 9; ; prefrontal cortex; ; nucleus accumbens; ; hypothalamus; ; putamen; ; caudate nucleus; ; hippocampus proper;
	Top expressed in
	left colon; ; Epithelium of stomach; ; duodenum; ; mucous cell of stomach; ; molar; ; medial vestibular nucleus; ; ileum; ; pyloric antrum; ; facial motor nucleus; ; pontine nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; creatine kinase activity ; nucleotide binding ; transferase activity, transferring phosphorus-containing groups ; catalytic activity ; ATP binding ; kinase activity ;
Cellular component	mitochondrial inner membrane ; membrane ; mitochondrion ;
Biological process	creatine metabolic process ; phosphorylation ; phosphocreatine biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	1159
	12716
	ENSG00000237289
	ENSMUSG00000000308
	P12532
	P30275
	NM_020990 ; NM_001375484
	NM_009897 ; NM_001355069
NP_001015001 ; NP_001308855 ; NP_001308856 ; NP_001308857 ; NP_001308858 ;
	NP_001362413 ; NP_066270
	NP_034027 ; NP_001341998
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Creatine kinase, mitochondrial 1B also known as CKMT1B is one of two genes which encode the ubiquitous mitochondrial creatine kinase (ubiquitous mtCK or CKMT1).^[5]

Function

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK (CKMT2) and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 (CKMT1A and CKMT1B (this gene)) have been identified which encode identical mitochondrial creatine kinase proteins.^[5]

Clinical significance

Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis.^[5]

Related Research Articles

<span class="mw-page-title-main">Creatine kinase</span> Class of enzymes

Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP.

POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.

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Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.

Cytochrome b5, form A, is a human microsomal cytochrome b5.

Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene.

5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial is an enzyme that in humans is encoded by the DBT gene.

EPH receptor A3 is a protein that in humans is encoded by the EPHA3 gene.

Creatine kinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene.

Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene.

2-Oxoisovalerate dehydrogenase subunit beta, mitochondrial is an enzyme that in humans is encoded by the BCKDHB gene.

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.

Adenylate kinase 2 is an enzyme that is encoded in humans by the AK2 gene. The AK2 protein is found in the intermembrane space of the mitochondrion.

Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.

Theo Wallimann is a Swiss biologist who was research group leader and Adjunct-Professor at the Institute of Cell Biology ETH Zurich and later at the Institute of Molecular Health Science at the ETH Zurich at the Biology Department, of the ETH Zurich, Switzerland.

Creatine kinase U-type, mitochondrial, also called ubiquitous mitochondrial creatine kinase (uMtCK), is in humans encoded by CKMT1A gene. CKMT1A catalyzes the reversible transfer of the γ-phosphate group of ATP to the guanidino group of Cr to yield ADP and PCr. The impairment of CKMT1A has been reported in ischaemia, cardiomyopathy, and neurodegenerative disorders. Overexpression of CKMT1A has been reported related with several tumors.

Creatine kinase, muscle also known as MCK is a creatine kinase that in humans is encoded by the MCK gene.

In molecular biology, the ATP:guanido phosphotransferase family is a family of structurally and functionally related enzymes, that reversibly catalyse the transfer of phosphate between ATP and various phosphagens. The enzymes belonging to this family include:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000237289 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000308 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B".

External links

Human CKMT1B genome location and CKMT1B gene details page in the UCSC Genome Browser .

Payne RM, Strauss AW (1995). "Expression of the mitochondrial creatine kinase genes". Mol. Cell. Biochem. 133–134: 235–43. doi:10.1007/BF01267957. PMID 7808456. S2CID 24795492.
Qin W, Khuchua Z, Cheng J, Boero J, Payne RM, Strauss AW (1998). "Molecular characterization of the creatine kinases and some historical perspectives". Mol. Cell. Biochem. 184 (1–2): 153–67. doi:10.1023/A:1006807515892. PMID 9746319. S2CID 1577790.
Haas RC, Strauss AW (1990). "Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes". J. Biol. Chem. 265 (12): 6921–7. doi: 10.1016/S0021-9258(19)39237-3 . PMID 2324105.
Haas RC, Korenfeld C, Zhang ZF, Perryman B, Roman D, Strauss AW (1989). "Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase". J. Biol. Chem. 264 (5): 2890–7. doi: 10.1016/S0021-9258(19)81696-4 . PMID 2914937.
Stallings RL, Olson E, Strauss AW, Thompson LH, Bachinski LL, Siciliano MJ (1988). "Human creatine kinase genes on chromosomes 15 and 19, and proximity of the gene for the muscle form to the genes for apolipoprotein C2 and excision repair". Am. J. Hum. Genet. 43 (2): 144–51. PMC 1715361 . PMID 3400641.
Jacobus WE, Moreadith RW, Vandegaer KM (1984). "Control of heart oxidative phosphorylation by creatine kinase in mitochondrial membranes". Ann. N. Y. Acad. Sci. 414 (1): 73–89. Bibcode:1983NYASA.414...73J. doi:10.1111/j.1749-6632.1983.tb31676.x. PMID 6584077. S2CID 7881554.
Brdiczka D, Kaldis P, Wallimann T (1994). "In vitro complex formation between the octamer of mitochondrial creatine kinase and porin". J. Biol. Chem. 269 (44): 27640–4. doi: 10.1016/S0021-9258(18)47033-0 . PMID 7525559.
Steeghs K, Merkx G, Wieringa B (1995). "The ubiquitous mitochondrial creatine kinase gene maps to a conserved region on human chromosome 15q15 and mouse chromosome 2 bands F1-F3". Genomics. 24 (1): 193–5. doi:10.1006/geno.1994.1604. PMID 7896282.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fritz-Wolf K, Schnyder T, Wallimann T, Kabsch W (1996). "Structure of mitochondrial creatine kinase". Nature. 381 (6580): 341–5. Bibcode:1996Natur.381..341F. doi:10.1038/381341a0. PMID 8692275. S2CID 4254253.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Thomure MF, Gast MJ, Srivastava N, Payne RM (1997). "Regulation of creatine kinase isoenzymes in human placenta during early, mid-, and late gestation". J. Soc. Gynecol. Investig. 3 (6): 322–7. doi:10.1016/S1071-5576(96)00043-3. PMID 8923416. S2CID 7814307.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Eder M, Fritz-Wolf K, Kabsch W, Wallimann T, Schlattner U (2000). "Crystal structure of human ubiquitous mitochondrial creatine kinase". Proteins. 39 (3): 216–25. doi:10.1002/(SICI)1097-0134(20000515)39:3<216::AID-PROT40>3.0.CO;2-#. PMID 10737943. S2CID 12531664.
Schlattner U, Wallimann T (2000). "Octamers of mitochondrial creatine kinase isoenzymes differ in stability and membrane binding". J. Biol. Chem. 275 (23): 17314–20. doi: 10.1074/jbc.M001919200 . PMID 10748055.
Schlattner U, Dolder M, Wallimann T, Tokarska-Schlattner M (2002). "Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium". J. Biol. Chem. 276 (51): 48027–30. doi: 10.1074/jbc.M106524200 . PMID 11602586.
Schlattner U, Wallimann T (2002). "A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance". J. Bioenerg. Biomembr. 32 (1): 123–31. doi:10.1023/A:1005576831968. PMID 11768757. S2CID 24884381.
Schlattner U, Möckli N, Speer O, Werner S, Wallimann T (2002). "Creatine kinase and creatine transporter in normal, wounded, and diseased skin". J. Invest. Dermatol. 118 (3): 416–23. doi: 10.1046/j.0022-202x.2001.01697.x . PMID 11874479.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000237289 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000308 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 "Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B".

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