CLASP1

Last updated

CLASP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CLASP1 , MAST1, cytoplasmic linker associated protein 1
External IDs OMIM: 605852; MGI: 1923957; HomoloGene: 41024; GeneCards: CLASP1; OMA:CLASP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 2: 121.34 – 121.65 Mb Chr 1: 118.39 – 118.61 Mb
PubMed search [3] [4]
Wikidata
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Cytoplasmic linker associated protein 1, also known as CLASP1, is a protein which in humans is encoded by the CLASP1 gene. [5]

Function

CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals [6] and plants. [7] CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle. [5] [8] CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle. [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000074054 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000064302 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CLASP1 cytoplasmic linker associated protein 1".
  6. Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Developmental Cell. 11 (1): 21–32. doi: 10.1016/j.devcel.2006.05.012 . PMID   16824950.
  7. Ambrose JC, Wasteneys GO (2008). "CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules". Molecular Biology of the Cell. 19 (11): 4730–4737. doi:10.1091/mbc.E08-06-0665. PMC   2575154 . PMID   18716054.
  8. Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC (June 2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi: 10.1016/S0092-8674(03)00465-3 . hdl: 10216/53832 . PMID   12837247.
  9. Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID   21822276. S2CID   8869880.

Further reading