Cytoplasmic linker associated protein 1, also known as CLASP1, is a protein which in humans is encoded by the CLASP1 gene. [5]
Cytoplasmic linker associated protein 1, also known as CLASP1, is a protein which in humans is encoded by the CLASP1 gene. [5]
CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals [6] and plants. [7] CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle. [5] [8] CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle. [9]
In cell biology, the spindle apparatus is the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells. It is referred to as the mitotic spindle during mitosis, a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis, a process that produces gametes with half the number of chromosomes of the parent cell.
A kinetochore is a disc-shaped protein structure associated with duplicated chromatids in eukaryotic cells where the spindle fibers attach during cell division to pull sister chromatids apart. The kinetochore assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis. The term kinetochore was first used in a footnote in a 1934 Cytology book by Lester W. Sharp and commonly accepted in 1936. Sharp's footnote reads: "The convenient term kinetochore has been suggested to the author by J. A. Moore", likely referring to John Alexander Moore who had joined Columbia University as a freshman in 1932.
Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere.
Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.
Centromere protein F is a protein that in humans is encoded by the CENPF gene. It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia.
Microtubule-associated protein RP/EB family member 1 is a protein that in humans is encoded by the MAPRE1 gene.
Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.
Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.
Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.
Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.
Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.
Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.
Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.
Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.
Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene.
Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog.
Microtubule-associated protein RP/EB family member 3 is a protein that in humans is encoded by the MAPRE3 gene.
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.
Pleckstrin homology-like domain family B member 1 is a protein that in humans is encoded by the PHLDB1 gene.
Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.
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