Casper Hoogenraad

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Casper Hoogenraad
Casper Hoogenraad.jpg
Casper C. Hoogenraad
Born (1973-01-31) January 31, 1973 (age 51)
Delft, The Netherlands
Nationality Dutch
Citizenship The Netherlands
Alma mater
Known for Molecular Neuroscience
Scientific career
Fields Neuroscience
Institutions
Doctoral advisor Frank Grosveld, Chris De Zeeuw
Other academic advisors Morgan Sheng
Website https://www.gene.com/scientists/our-scientists/casper-hoogenraad

Casper Hoogenraad is a Dutch Cell Biologist who specializes in molecular neuroscience. The focus of his research is the basic molecular and cellular mechanisms that regulate the development and function of the brain. As of January 2020, he serves as Vice President of Neuroscience at Genentech Research and Early Development.

Contents

Biography and academic career

Casper Hoogenraad was born in 1973 in Delft and grew up in Gouda, in The Netherlands. He received his B.S. in Biochemistry and M.S. in Molecular Biology from Utrecht University, and his doctorate in Cell Biology from the Erasmus University Rotterdam. [1] In 2002, Hoogenraad started his post-doctoral research at Massachusetts Institute of Technology in Cambridge, USA. In 2005, he returned to the Netherlands and joined the faculty of the Erasmus University Medical Center in Rotterdam as Associate Professor in the Department of Neuroscience. In 2011 he joined Utrecht University as full Professor of Molecular Neuroscience, and served as Chair of Cell Biology, Neurobiology and Biophysics for 10 years. [2] He is Adjunct Professor in Department of Biochemistry and Biophysics at University of California, San Francisco (UCSF). [3]

During his career, he discovered molecular mechanisms and cell biological processes that control cytoskeleton remodeling and cargo trafficking during the development and function of the brain. Hoogenraad published over 250 research articles, reviews and books, focused on synaptic function [4] [5] [6] [7] dendritic spine plasticity [8] [9] [10] [11] neuronal polarity [12] [13] [14] [15] organelle sorting mechanisms [16] [17] [18] [19] [20] the axon initial segment [21] [22] [23] [24] [25] cytoskeleton remodeling [26] [27] [28] [29] microtubule dynamics [30] [31] [32] [33] [34] fundamental transport mechanisms [35] [36] [37] [38] [39] axon regeneration [40] [41] and neurodegeneration [42] [43] [44] [45] . See for full publication record - Pubmed, [46] Google Scholar, [47] ORCID [48]

Industrial career

Hoogenraad was recruited to Genentech, a member of the Roche Group, as Senior Fellow and head of Neuroscience. [49] As of January 2020, he is Vice President of Neuroscience at Genentech Research and Early Development. [50] In this role, he is Head of the Neuroscience Department, responsible for research and drug discovery activities in Neuroscience and oversees Genentech’s Neuroscience disease pipeline programs. He is also responsible for Translational Neuroscience, Neuroscience Stem Cell group, Department of Translational Imaging, and Department of Molecular Biology.

Honors and Awards

He is an elected member of the European Molecular Biology Organization, [51] The Young Academy’ of the Royal Netherlands Academy of Sciences, [52] Young Academy of Europe [53] and the Editorial Board of Neuron [54] and The EMBO Journal. [55] In 2016 he became the 10th recipient of the IBRO-Kemali Prize, in the field of basic and clinical Neuroscience. [56] Some of his awards: NWO Talent stipendium, Human Frontiers Long-Term Fellowship, European Younng Investigators (EURYI) award, Dutch Innovational Research VIDI and VICI, European Research Council (ERC) - consolidator grant.

Science outreach

In 2013, his laboratory made an animation movie, named 'A Day in the Life of a Motor Protein', which has received >1 million views on youtube. [57] During this short five-minute movie, we follow John, a motor protein, who has to transport a large package through the narrow streets in the city of Utrecht, illustrating the importance and challenges of intracellular transport.

Related Research Articles

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References

  1. ↑ PhD thesis. 12 September 2001. ISBN   978-90-77017-07-4.{{cite book}}: |newspaper= ignored (help)
  2. ↑ "Utrecht lab". UU, Utrecht University. 20 December 2023.
  3. ↑ "UCSF lab".
  4. ↑ Sheng M, Hoogenraad CC (2007). "The postsynaptic architecture of excitatory synapses: a more quantitative view". Annu Rev Biochem. 76: 823–47. doi:10.1146/annurev.biochem.76.060805.160029. PMID   17243894.
  5. ↑ Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, Sheng M (2005). "GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking". Nat Neurosci. 8 (7): 906–15. doi:10.1038/nn1487. PMID   15965473. S2CID   23686585.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ↑ Hoogenraad CC, Popa I, Futai K, Martinez-Sanchez E, Wulf PS, van Vlijmen T; et al. (2010). "Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes". PLOS Biol. 8 (1): e1000283. doi: 10.1371/journal.pbio.1000283 . PMC   2808209 . PMID   20098723.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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  32. ↑ Yau KW, van Beuningen SF, Cunha-Ferreira I, Cloin BM, van Battum EY, Will L; et al. (2014). "Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development". Neuron. 82 (5): 1058–73. doi:10.1016/j.neuron.2014.04.019. PMID   24908486.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  33. ↑ Yau KW, Schätzle P, Tortosa E, Pagès S, Holtmaat A, Kapitein LC; et al. (2016). "Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation". J Neurosci. 36 (4): 1071–85. doi:10.1523/JNEUROSCI.2430-15.2016. PMC   4728718 . PMID   26818498.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  34. ↑ Cunha-Ferreira I, Chazeau A, Buijs RR, Stucchi R, Will L, Pan X; et al. (2018). "The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development". Cell Rep. 24 (4): 791–800. doi:10.1016/j.celrep.2018.06.093. PMC   6083040 . PMID   30044976.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  35. ↑ Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R; et al. (2001). "Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes". EMBO J. 20 (15): 4041–54. doi:10.1093/emboj/20.15.4041. PMC   149157 . PMID   11483508.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  36. ↑ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T; et al. (2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat Cell Biol. 4 (12): 986–92. doi:10.1038/ncb891. PMID   12447383. S2CID   7953140.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  37. ↑ van Bergeijk P, Adrian M, Hoogenraad CC, Kapitein LC (2015). "Optogenetic control of organelle transport and positioning". Nature. 518 (7537): 111–114. Bibcode:2015Natur.518..111V. doi:10.1038/nature14128. PMC   5063096 . PMID   25561173.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  38. ↑ Kevenaar JT, Bianchi S, van Spronsen M, Olieric N, Lipka J, Frias CP; et al. (2016). "Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity". Curr Biol. 26 (7): 849–61. doi:10.1016/j.cub.2016.01.048. PMID   26948876.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  39. ↑ Hummel JJA, Hoogenraad CC (2021). "Inducible manipulation of motor-cargo interaction using engineered kinesin motors". J Cell Sci. 134 (15). doi:10.1242/jcs.258776. PMC   8353518 . PMID   34342354.
  40. ↑ Erez H, Malkinson G, Prager-Khoutorsky M, De Zeeuw CI, Hoogenraad CC, Spira ME (2007). "Formation of microtubule-based traps controls the sorting and concentration of vesicles to restricted sites of regenerating neurons after axotomy". J Cell Biol. 176 (4): 497–507. doi:10.1083/jcb.200607098. PMC   2063984 . PMID   17283182.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  41. ↑ Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M; et al. (2011). "Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury". Science. 331 (6019): 928–31. Bibcode:2011Sci...331..928H. doi:10.1126/science.1201148. PMC   3330754 . PMID   21273450.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  42. ↑ Teuling E, Ahmed S, Haasdijk E, Demmers J, Steinmetz MO, Akhmanova A; et al. (2007). "Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates". J Neurosci. 27 (36): 9801–15. doi:10.1523/JNEUROSCI.2661-07.2007. PMC   6672975 . PMID   17804640.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  43. ↑ Kuijpers M, Yu KL, Teuling E, Akhmanova A, Jaarsma D, Hoogenraad CC (2013). "The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites". EMBO J. 32 (14): 2056–72. doi:10.1038/emboj.2013.131. PMC   3715857 . PMID   23736259.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  44. ↑ Tortosa E, Sengupta Ghosh A, Li Q, Wong WR, Hinkle T, Sandoval W; et al. (2022). "Stress-induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration". EMBO J. 41 (14): e110155. doi:10.15252/embj.2021110155. PMC   9289706 . PMID   35611591.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  45. ↑ Adrian M, Weber M, Tsai MC, Glock C, Kahn OI, Phu L; et al. (2023). "Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release". Nat Commun. 14 (1): 6322. Bibcode:2023NatCo..14.6322A. doi:10.1038/s41467-023-41891-6. PMC   10562429 . PMID   37813836.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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  51. ↑ "EMBO member". EMBO Press. Archived from the original on 2015-12-01.
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