CLC (gene)

CLC
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1G86, 1HDK, 1LCL, 1QKQ
Identifiers
Aliases	CLC , GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN, Charcot-Leyden crystal galectin, galectin-10
External IDs	OMIM: 153310 HomoloGene: 130498 GeneCards: CLC
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,738,029 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; bone marrow; ; bone marrow cells; ; monocyte; ; blood; ; gallbladder; ; appendix; ; spleen; ; rectum; ; smooth muscle tissue;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type endopeptidase activity involved in apoptotic process ; lysophospholipase activity ; protein binding ; carbohydrate binding ; identical protein binding ;
Cellular component	cytoplasm ; cytosol ; collagen-containing extracellular matrix ;
Biological process	multicellular organism development ; T cell apoptotic process ; regulation of T cell cytokine production ; regulation of activated T cell proliferation ; regulation of T cell anergy ;
	Sources:Amigo / QuickGO
Orthologs
	1178
	n/a
	ENSG00000105205
	n/a
	Q05315
	n/a
	NM_001828
	n/a
	NP_001819
	n/a
	Wikidata
View/Edit Human

Last updated January 27, 2024

Galectin-10 is an enzyme that in humans is encoded by the CLC gene.^[3]^[4]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.^[4]

Related Research Articles

Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: the protein contains 152 amino acids and its molecular weight is 17 kDa. IL-3 is produced as a monomer by activated T cells, monocytes/macrophages and stroma cells. The major function of IL-3 cytokine is to regulate the concentrations of various blood-cell types. It induces proliferation and differentiation in both early pluripotent stem cells and committed progenitors. It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype switching.

Eosinophil major basic protein, often shortened to major basic protein is encoded in humans by the PRG2 gene.

Charcot–Leyden crystals are microscopic crystals composed of eosinophil protein galectin-10 found in people who have allergic diseases such as asthma or parasitic infections such as parasitic pneumonia or ascariasis.

Leukosialin also known as sialophorin or CD43 is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.

Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In humans, the eosinophil cationic protein is encoded by the RNASE3 gene.

Eosinophil-derived neurotoxin is an enzyme that in humans is encoded by the RNASE2 gene.

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.

Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene.

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene and is pro-apoptotic.

Factor interacting with PAPOLA and CPSF1 is a protein that in humans is encoded by the FIP1L1 gene. A medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause clonal hypereosinophilia and leukemic diseases in humans.

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.

Galectin-7 is a protein that in humans is encoded by the LGALS7 gene.

Placental protein 13 (PP13) is a protein that in humans is encoded by the LGALS13 gene.

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.

Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene.

Myeloid leukemia factor 1 is a protein that in humans is encoded by the MLF1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105205 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
1 2 "CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]".

External links

Human CLC genome location and CLC gene details page in the UCSC Genome Browser .

Gleich GJ, Loegering DA, Mann KG, Maldonado JE (1976). "Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils". J. Clin. Invest. 57 (3): 633–40. doi:10.1172/JCI108319. PMC 436696 . PMID 942977.
Golightly LM, Thomas LL, Dvorak AM, Ackerman SJ (1992). "Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils". J. Leukoc. Biol. 51 (4): 386–92. doi:10.1002/jlb.51.4.386. PMID 1373430. S2CID 24236041.
Dvorak AM, Weller PF, Monahan-Earley RA, et al. (1990). "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome". Lab. Invest. 62 (5): 590–607. PMID 2160562.
Dvorak AM, Letourneau L, Weller PF, Ackerman SJ (1990). "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas". Lab. Invest. 62 (5): 608–15. PMID 2160563.
Dvorak AM, Ackerman SJ (1989). "Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to granules and intragranular crystals in mature human basophils". Lab. Invest. 60 (4): 557–67. doi: 10.1111/1523-1747.ep12703656 . PMID 2709814.
Sieker LC, Turley S, Le Trong I, et al. (1989). "Crystallographic characterization of human eosinophil Charcot-Leyden crystals". J. Mol. Biol. 204 (2): 489–91. doi:10.1016/0022-2836(88)90590-6. PMID 3221396.
Weller PF, Bach D, Austen KF (1982). "Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals". J. Immunol. 128 (3): 1346–9. doi: 10.4049/jimmunol.128.3.1346 . PMID 6173432.
Weller PF, Bach DS, Austen KF (1985). "Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase)". J. Biol. Chem. 259 (24): 15100–5. doi: 10.1016/S0021-9258(17)42520-8 . PMID 6511787.
Gomolin HI, Yamaguchi Y, Paulpillai AV, et al. (1993). "Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter". Blood. 82 (6): 1868–74. doi: 10.1182/blood.V82.6.1868.1868 . PMID 8400237.
Ackerman SJ, Corrette SE, Rosenberg HF, et al. (1993). "Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily". J. Immunol. 150 (2): 456–68. doi: 10.4049/jimmunol.150.2.456 . PMID 8419478.
Leonidas DD, Elbert BL, Zhou Z, et al. (1996). "Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins". Structure. 3 (12): 1379–93. doi: 10.1016/S0969-2126(01)00275-1 . PMID 8747464.
Dyer KD, Handen JS, Rosenberg HF (1997). "The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes". Genomics. 40 (2): 217–21. doi: 10.1006/geno.1996.4590 . PMID 9119387.
Swaminathan GJ, Leonidas DD, Savage MP, et al. (1999). "Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution". Biochemistry. 38 (42): 13837–43. doi:10.1021/bi990756e. PMID 10529229.
Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica. 87 (6): 569–77. PMID 12031912.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Abedin MJ, Kashio Y, Seki M, et al. (2003). "Potential roles of galectins in myeloid differentiation into three different lineages". J. Leukoc. Biol. 73 (5): 650–6. doi: 10.1189/jlb.0402163 . PMID 12714580. S2CID 21337581.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Nielsen K, Heegaard S, Vorum H, et al. (2005). "Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients". Cornea. 24 (6): 661–8. doi:10.1097/01.ico.0000153556.59407.69. PMID 16015083. S2CID 21026845.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105205 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1577491-3] Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.

[entrez-4] 1 2 "CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]".

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CLC (gene)

Contents

See also

Related Research Articles

References

External links

Further reading