CLDN12

CLDN12
Identifiers
Aliases	CLDN12 , claudin 12
External IDs	OMIM: 611232 MGI: 1929288 HomoloGene: 40809 GeneCards: CLDN12
Gene location (Human)
Chr.	Chromosome 7 (human)
End	90,513,402 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	5,564,958 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; islet of Langerhans; ; pancreatic epithelial cell; ; right lobe of liver; ; rectum; ; pituitary gland; ; anterior pituitary; ; gallbladder; ; deltoid muscle; ; Left adrenal gland;
	Top expressed in
	otolith organ; ; utricle; ; interventricular septum; ; retinal pigment epithelium; ; ascending aorta; ; supraoptic nucleus; ; ciliary body; ; primitive streak; ; aortic valve; ; lacrimal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity ; identical protein binding ; protein binding ;
Cellular component	integral component of membrane ; cell junction ; lateral plasma membrane ; membrane ; cell periphery ; bicellular tight junction ; plasma membrane ;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ;
	Sources:Amigo / QuickGO
Orthologs
	9069
	64945
	ENSG00000157224
	ENSMUSG00000046798
	P56749
	Q9ET43
	NM_012129 ; NM_001185072 ; NM_001185073
	NM_001193659 ; NM_001193660 ; NM_001193661 ; NM_022890
	NP_001172001 ; NP_001172002 ; NP_036261
	NP_001180588 ; NP_001180589 ; NP_001180590 ; NP_075028
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Claudin-12 is a protein that in humans is encoded by the CLDN12 gene.^[5] It belongs to the group of claudins.

Related Research Articles

Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions. Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm.

Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins.

Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene. It belongs to the group of claudins.

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. It is a member of the claudin protein family.

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.

Claudin-6 is a protein that in humans is encoded by the CLDN6 gene. It belongs to the group of claudins. The knockout mice of mouse homolog exhibit no phenotype, indicating that claudin-6 is dispensable for normal development and homeostasis.

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. It belongs to the group of claudins.

Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. It belongs to the group of claudins.

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins and was the first member of the family to be knocked out in mice, thereby demonstrating the central role of claudins for intramembranous strands observed in freeze-fracture images.

Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins.

Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.

Claudin-9 is a protein that in humans is encoded by the CLDN9 gene. It belongs to the group of claudins.

Claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function. Claudin-17 is a protein that in humans is encoded by the CLDN17 gene. It belongs to the group of claudins. It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules. Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress. Cells. 2022 May 29;11(11):1782.

Claudin-10 is a protein that in humans is encoded by the CLDN10 gene. It belongs to the group of claudins.

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene. It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.

Claudin-20 is a protein that in humans is encoded by the CLDN20 gene. It belongs to the group of claudins.

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene. It belongs to the group of claudins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000157224 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046798 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CLDN12 claudin 12".

External links

Human CLDN12 genome location and CLDN12 gene details page in the UCSC Genome Browser .

Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi: 10.1034/j.1600-0854.2001.020203.x . PMID 11247307. S2CID 12132159.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi: 10.1016/S0079-6107(02)00037-8 . PMID 12475568.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911 . PMID 11585919.
Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. doi: 10.1681/ASN.V134875 . PMID 11912246.
Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes". Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID 12067061.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Kitajiri SI, Furuse M, Morita K, et al. (2004). "Expression patterns of claudins, tight junction adhesion molecules, in the inner ear". Hear. Res. 187 (1–2): 25–34. doi:10.1016/S0378-5955(03)00338-1. PMID 14698084. S2CID 31183039.
Acharya P, Beckel J, Ruiz WG, et al. (2004). "Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium". Am. J. Physiol. Renal Physiol. 287 (2): F305–18. doi:10.1152/ajprenal.00341.2003. PMID 15068973.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318 . PMID 26680015.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000157224 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046798 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLDN12 claudin 12".

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CLDN12

Contents

Related Research Articles

References

External links

Further reading