CLDN2

CLDN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YYX
Identifiers
Aliases	CLDN2 , claudin 2, OAZON
External IDs	OMIM: 300520; MGI: 1276110; HomoloGene: 9621; GeneCards: CLDN2; OMA:CLDN2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.3 Start 106,900,164 bp [1] End 106,930,861 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F1 Start 138,701,577 bp [2] End 138,712,135 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell gallbladder islet of Langerhans right lobe of liver seminal vesicula renal cortex renal medulla duodenum caput epididymis human kidney Top expressed in Epithelium of choroid plexus human kidney proximal tubule right kidney choroid plexus of fourth ventricle crypt of lieberkuhn of small intestine efferent ductule left colon yolk sac left lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding structural molecule activity Cellular component cell junction integral component of membrane bicellular tight junction plasma membrane membrane Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9075 12738 Ensembl ENSG00000165376 ENSMUSG00000047230 UniProt P57739 O88552 RefSeq (mRNA) NM_020384 NM_001171092 NM_001171095 NM_016675 RefSeq (protein) NP_001164563 NP_001164566 NP_065117 NP_057884 Location (UCSC) Chr X: 106.9 – 106.93 Mb Chr X: 138.7 – 138.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. ^{[5] [6]} It belongs to the group of claudins.

Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM] ^[6]

Function

Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule. ^[7] Mice that are deficient in claudin-2 have reduced reabsorption of Na ⁺ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations. ^[8] Furthermore, claudin-2 has been shown to form paracellular channels for water. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000165376 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047230 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Morita K, Furuse M, Fujimoto K, Tsukita S (March 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi: 10.1073/pnas.96.2.511 . PMC   15167 . PMID   9892664.
6. "Entrez Gene: CLDN2 claudin 2".
7. Muto S, Hata M, Taniguchi J, Tsuruoka S, Moriwaki K, Saitou M, Furuse K, Sasaki H, Fujimura A, Imai M, Kusano E, Tsukita S, Furuse M (2010). "Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules". Proceedings of the National Academy of Sciences. 107 (17): 8011–8016. Bibcode:2010PNAS..107.8011M. doi: 10.1073/pnas.0912901107 . PMC   2867900 . PMID   20385797.
8. Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J, Schulzke JD, Fromm M (2002). "Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells". Journal of Cell Science. 115 (Pt 24): 4969–76. doi:10.1242/jcs.00165. PMID   12432083. S2CID   30696935.
9. Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, Gunzel D, Fromm M (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science. 123 (11): 1913–1921. doi:10.1242/jcs.060665. PMID   20460438. S2CID   19797060.

External links

• Human CLDN2 genome location and CLDN2 gene details page in the UCSC Genome Browser .

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC   11537529 . PMID   10690502. S2CID   26473781.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID   11247307. S2CID   12132159.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID   11283726. S2CID   36524601.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID   12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID   12475568.
• Furuse M, Fujita K, Hiiragi T, et al. (1998). "Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin". J. Cell Biol. 141 (7): 1539–50. doi:10.1083/jcb.141.7.1539. PMC   2132999 . PMID   9647647.
• Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC   2168087 . PMID   10601346.
• Sakaguchi T, Gu X, Golden HM, et al. (2002). "Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha". J. Biol. Chem. 277 (24): 21361–70. doi: 10.1074/jbc.M110261200 . PMID   11934881.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Colegio OR, Van Itallie C, Rahner C, Anderson JM (2003). "Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture". Am. J. Physiol., Cell Physiol. 284 (6): C1346–54. doi:10.1152/ajpcell.00547.2002. PMID   12700140.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Mankertz J, Hillenbrand B, Tavalali S, et al. (2004). "Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity". Biochem. Biophys. Res. Commun. 314 (4): 1001–7. doi:10.1016/j.bbrc.2003.12.185. PMID   14751232.
• Yamauchi K, Rai T, Kobayashi K, et al. (2004). "Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4690–4. Bibcode:2004PNAS..101.4690Y. doi: 10.1073/pnas.0306924101 . PMC   384808 . PMID   15070779.
• Escaffit F, Boudreau F, Beaulieu JF (2005). "Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells". J. Cell. Physiol. 203 (1): 15–26. doi:10.1002/jcp.20189. PMID   15389642. S2CID   39780124.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC   4777318 . PMID   26680015.