CLDN20

CLDN20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YYX
Identifiers
Aliases	CLDN20 , claudin 20
External IDs	MGI: 3646757; HomoloGene: 47972; GeneCards: CLDN20; OMA:CLDN20 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q25.3 Start 155,264,013 bp [1] End 155,276,548 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A1 Start 3,582,829 bp [2] End 3,583,484 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell testicle tendon stromal cell of endometrium tibial nerve epithelium of colon Achilles tendon right adrenal cortex left adrenal gland smooth muscle tissue Top expressed in embryo secondary oocyte zygote granulocyte bone marrow primary oocyte ganglionic eminence olfactory bulb striatum of neuraxis neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding Cellular component integral component of membrane cell junction plasma membrane membrane bicellular tight junction Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 49861 621628 Ensembl ENSG00000171217 ENSMUSG00000091530 UniProt P56880 G5E8X0 RefSeq (mRNA) NM_001001346 NM_001101560 RefSeq (protein) NP_001001346 NP_001095030 Location (UCSC) Chr 6: 155.26 – 155.28 Mb Chr 17: 3.58 – 3.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-20 is a protein that in humans is encoded by the CLDN20 gene. ^{[5] [6]} It belongs to the group of claudins.

References

1. GRCh38: Ensembl release 89: ENSG00000171217 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000091530 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hewitt KJ, Agarwal R, Morin PJ (Aug 2006). "The claudin gene family: expression in normal and neoplastic tissues". BMC Cancer. 6: 186. doi: 10.1186/1471-2407-6-186 . PMC   1538620 . PMID   16836752.
6. "Entrez Gene: CLDN20 claudin 20".

External links

• Human CLDN20 genome location and CLDN20 gene details page in the UCSC Genome Browser .

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC   11537529 . PMID   10690502. S2CID   26473781.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID   11247307. S2CID   12132159.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID   11283726. S2CID   36524601.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID   12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID   12475568.
• Berg M, Geisel A, Necheles H (1975). "The influence of carbenoxolone on steroid-induced ulcer and mucus secretion in the rat". The American Journal of Digestive Diseases. 20 (2): 134–7. doi:10.1007/BF01072339. PMID   1124737. S2CID   29907180.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–59. doi:10.1021/acs.jproteome.5b00769. PMC   4777318 . PMID   26680015.