CLDN6

CLDN6
Identifiers
Aliases	CLDN6 , claudin 6
External IDs	OMIM: 615798; MGI: 1859284; HomoloGene: 10300; GeneCards: CLDN6; OMA:CLDN6 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 3,014,712 bp [1] End 3,020,071 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 23,898,223 bp [2] End 23,901,420 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad islet of Langerhans putamen placenta cerebellar hemisphere striated muscle tissue skeletal muscle tissue right hemisphere of cerebellum stromal cell of endometrium metanephros Top expressed in yolk sac embryo epiblast genital tubercle tail of embryo primitive streak blastocyst glomerulus morula renal vein More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding protein binding virus receptor activity Cellular component bicellular tight junction cell junction membrane apicolateral plasma membrane integral component of membrane plasma membrane Biological process cell-cell junction organization viral process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9074 54419 Ensembl ENSG00000184697 ENSMUSG00000023906 UniProt P56747 Q9Z262 RefSeq (mRNA) NM_021195 NM_018777 RefSeq (protein) NP_067018 NP_061247 Location (UCSC) Chr 16: 3.01 – 3.02 Mb Chr 17: 23.9 – 23.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-6 is a protein that in humans is encoded by the CLDN6 gene. ^{[5] [6] [7]} It belongs to the group of claudins. The knockout mice of mouse homolog exhibit no phenotype, indicating that claudin-6 is dispensable for normal development and homeostasis.

References

1. GRCh38: Ensembl release 89: ENSG00000184697 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023906 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi: 10.1073/pnas.96.2.511 . PMC   15167 . PMID   9892664.
6. Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus". J Virol. 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC   2268462 . PMID   18234789.
7. "Entrez Gene: CLDN6 claudin 6".

External links

• Human CLDN6 genome location and CLDN6 gene details page in the UCSC Genome Browser .

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC   11537529 . PMID   10690502. S2CID   26473781.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi: 10.1034/j.1600-0854.2001.020203.x . PMID   11247307.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID   11283726. S2CID   36524601.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID   12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi: 10.1016/S0079-6107(02)00037-8 . PMID   12475568.
• Morita K, Sasaki H, Furuse M, Tsukita S (1999). "Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells". J. Cell Biol. 147 (1): 185–94. doi:10.1083/jcb.147.1.185. PMC   2164984 . PMID   10508865.
• Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC   2168087 . PMID   10601346.
• Turksen K, Troy TC (2001). "Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium". Dev. Dyn. 222 (2): 292–300. doi: 10.1002/dvdy.1174 . PMID   11668606. S2CID   22718714.
• Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. doi: 10.1681/ASN.V134875 . PMID   11912246.
• Turksen K, Troy TC (2002). "Permeability barrier dysfunction in transgenic mice overexpressing claudin 6". Development. 129 (7): 1775–84. doi: 10.1242/dev.129.7.1775 . PMID   11923212.
• Morita K, Furuse M, Yoshida Y, et al. (2002). "Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis". J. Invest. Dermatol. 118 (6): 1073–9. doi: 10.1046/j.1523-1747.2002.01774.x . PMID   12060405.
• Reyes JL, Lamas M, Martin D, et al. (2003). "The renal segmental distribution of claudins changes with development". Kidney Int. 62 (2): 476–87. doi: 10.1046/j.1523-1755.2002.00479.x . PMID   12110008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID   12736707.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC   4777318 . PMID   26680015.