CLDN9

CLDN9
Identifiers
Aliases	CLDN9 , claudin 9, DFNB116
External IDs	OMIM: 615799; MGI: 1913100; HomoloGene: 10656; GeneCards: CLDN9; OMA:CLDN9 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 3,012,923 bp [1] End 3,014,505 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 23,901,558 bp [2] End 23,903,000 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum Pituitary Gland anterior pituitary testicle blood body of pancreas right uterine tube right lobe of liver C1 segment apex of heart Top expressed in vestibular sensory epithelium vestibular membrane of cochlear duct olfactory epithelium stria vascularis Pituitary Gland lumbar spinal ganglion utricle Epithelium of choroid plexus median eminence internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding protein binding virus receptor activity Cellular component integral component of membrane membrane bicellular tight junction cell junction intracellular membrane-bounded organelle plasma membrane Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules viral process cell-cell junction organization viral entry into host cell tight junction organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9080 56863 Ensembl ENSG00000213937 ENSMUSG00000066720 UniProt O95484 Q9Z0S7 RefSeq (mRNA) NM_020982 NM_020293 RefSeq (protein) NP_066192 NP_064689 Location (UCSC) Chr 16: 3.01 – 3.01 Mb Chr 17: 23.9 – 23.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-9 is a protein that in humans is encoded by the CLDN9 gene. ^{[5] [6] [7]} It belongs to the group of claudins.

This gene is expressed in the inner ear, olfactory epithelium, and anterior pituitary gland ^[8] and is involved in hearing. ^{[9] [10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000213937 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066720 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Peacock RE, Keen TJ, Inglehearn CF (Mar 1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID   9441748.
6. Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus". J Virol. 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC   2268462 . PMID   18234789.
7. "Entrez Gene: CLDN9 claudin 9".
8. Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H (Nov 2021). "Claudin-9 constitutes tight junctions of folliclo-stellate cells in the anterior pituitary gland". Scientific Reports. 11 (1): 21642. Bibcode:2021NatSR..1121642H. doi:10.1038/s41598-021-01004-z. PMC   8568902 . PMID   34737342.
9. Gene discovery reveals a critical protein's function in hearing
10. Nakano Y, Kim SH, Kim HM, Sanneman JD, Zhang Y, Smith RJ, Marcus DC, Wangemann P, Nessler RA, Bánfi B (Aug 2009). "A claudin-9-based ion permeability barrier is essential for hearing". PLOS Genetics. 5 (8): e1000610. doi: 10.1371/journal.pgen.1000610 . PMC   2720454 . PMID   19696885.
11. Sineni CJ, Yildirim-Baylan M, Guo S, Camarena V, Wang G, Tokgoz-Yilmaz S, Duman D, Bademci G, Tekin M (Oct 2019). "A truncating CLDN9 variant if associated with autosomal recessive nonsyndromic hearing loss". Human Genetics. 138 (10): 1071–1075. doi:10.1007/s00439-019-02037-1. PMC   6745279 . PMID   31175426.

External links

• Human CLDN9 genome location and CLDN9 gene details page in the UCSC Genome Browser .

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC   11537529 . PMID   10690502. S2CID   26473781.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID   11247307. S2CID   12132159.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID   11283726. S2CID   36524601.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID   12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID   12475568.
• Yi X, Wang Y, Yu FS (2000). "Corneal epithelial tight junctions and their response to lipopolysaccharide challenge". Invest. Ophthalmol. Vis. Sci. 41 (13): 4093–100. PMID   11095601.
• Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. doi: 10.1681/ASN.V134875 . PMID   11912246.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID   12736707.
• Ban Y, Dota A, Cooper LJ, et al. (2003). "Tight junction-related protein expression and distribution in human corneal epithelium". Exp. Eye Res. 76 (6): 663–9. doi:10.1016/S0014-4835(03)00054-X. PMID   12742348.
• Kitajiri SI, Furuse M, Morita K, et al. (2004). "Expression patterns of claudins, tight junction adhesion molecules, in the inner ear". Hear. Res. 187 (1–2): 25–34. doi:10.1016/S0378-5955(03)00338-1. PMID   14698084. S2CID   31183039.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zheng A, Yuan F, Li Y, et al. (2007). "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus". J. Virol. 81 (22): 12465–71. doi:10.1128/JVI.01457-07. PMC   2169001 . PMID   17804490.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC   4777318 . PMID   26680015.