CNOT3

CNOT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C0D, 4C0G, 5FU6, 5FU7
Identifiers
Aliases	CNOT3 , LENG2, NOT3, NOT3H, CCR4-NOT transcription complex subunit 3, IDDSADF
External IDs	OMIM: 604910; MGI: 2385261; HomoloGene: 133900; GeneCards: CNOT3; OMA:CNOT3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.42 Start 54,137,749 bp [1] End 54,155,681 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A1 Start 3,645,268 bp [2] End 3,661,109 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve pituitary gland granulocyte right uterine tube anterior pituitary right hemisphere of cerebellum ventricular zone left lobe of thyroid gland right lobe of thyroid gland blood Top expressed in zygote genital tubercle tail of embryo granulocyte ventricular zone yolk sac neural layer of retina lip hand Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm CCR4-NOT complex cytosol P-body nucleus CCR4-NOT core complex Biological process nuclear-transcribed mRNA poly(A) tail shortening multicellular organism development gene silencing negative regulation of translation regulation of stem cell population maintenance regulation of transcription, DNA-templated trophectodermal cell differentiation regulation of translation transcription, DNA-templated DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4849 232791 Ensembl ENSG00000088038 ENSG00000277600 ENSG00000277114 ENSG00000274616 ENSG00000275979 ENSG00000277615 ENSG00000276082 ENSG00000274176 ENSG00000274941 ENSG00000273943 ENSMUSG00000035632 UniProt O75175 Q8K0V4 RefSeq (mRNA) NM_014516 NM_146176 RefSeq (protein) NP_055331 NP_666288 Location (UCSC) Chr 19: 54.14 – 54.16 Mb Chr 7: 3.65 – 3.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene. ^{[5] [6] [7]} It is a subunit of the CCR4-Not deadenylase complex.

Interactions

CNOT3 has been shown to interact with CNOT8. ^[5]

References

1. ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 GRCh38: Ensembl release 89: ENSG00000088038, ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035632 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC   102560 . PMID   10637334.
6. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
7. "Entrez Gene: CNOT3 CCR4-NOT transcription complex, subunit 3".

Further reading

• Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID   10941842. S2CID   20719684.
• Aoki T, Okada N, Wakamatsu T, Tamura TA (2002). "TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3". Biochem. Biophys. Res. Commun. 296 (5): 1097–103. doi:10.1016/S0006-291X(02)02031-4. PMID   12207886.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID   15752756.

External links

• Human CNOT3 genome location and CNOT3 gene details page in the UCSC Genome Browser .