CNOT8

CNOT8
Identifiers
Aliases	CNOT8 , CAF1, CALIF, Caf1b, POP2, hCAF1, CCR4-NOT transcription complex subunit 8
External IDs	OMIM: 603731; MGI: 1916375; HomoloGene: 48304; GeneCards: CNOT8; OMA:CNOT8 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.2 Start 154,857,553 bp [1] End 154,876,792 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.3 Start 57,994,979 bp [2] End 58,009,420 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte sperm right lung ganglionic eminence Achilles tendon granulocyte rectum upper lobe of left lung ventricular zone Top expressed in secondary oocyte neural layer of retina thymus zygote medial ganglionic eminence granulocyte ventricular zone primary oocyte neural tube morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity 3'-5'-exoribonuclease activity DNA-binding transcription factor activity metal ion binding protein binding RNA binding nucleic acid binding nuclease activity exonuclease activity hydrolase activity Cellular component cytoplasm cytosol CCR4-NOT complex intracellular anatomical structure nucleus P-body CCR4-NOT core complex Biological process regulation of transcription, DNA-templated nucleic acid phosphodiester bond hydrolysis positive regulation of mRNA catabolic process transcription, DNA-templated gene silencing by miRNA positive regulation of cell population proliferation exonucleolytic catabolism of deadenylated mRNA gene silencing regulation of translation negative regulation of cell population proliferation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA poly(A) tail shortening negative regulation of translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9337 69125 Ensembl ENSG00000155508 ENSMUSG00000020515 UniProt Q9UFF9 Q9D8X5 RefSeq (mRNA) NM_001301073 NM_001301074 NM_001301075 NM_001301077 NM_001301080 NM_001301082 NM_001301083 NM_001301086 NM_004779 NM_026949 NM_001356477 NM_001363084 NM_001363085 NM_001363086 RefSeq (protein) NP_001288002 NP_001288003 NP_001288004 NP_001288006 NP_001288009 NP_001288011 NP_001288012 NP_001288015 NP_004770 NP_081225 NP_001343406 NP_001350013 NP_001350014 NP_001350015 Location (UCSC) Chr 5: 154.86 – 154.88 Mb Chr 11: 57.99 – 58.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene. ^{[5] [6] [7]} It is a subunit of the CCR4-Not deadenylase complex.

Interactions

CNOT8 has been shown to interact with BTG2, ^[8] BTG1, ^{[8] [9]} CNOT1 ^{[6] [10]} and CNOT3. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000155508 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020515 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fidler C, Wainscoat JS, Boultwood J (May 1999). "The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome". Genomics. 56 (1): 134–6. doi:10.1006/geno.1998.5687. PMID   10036195.
6. Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC   102560 . PMID   10637334.
7. "Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8".
8. Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi: 10.1074/jbc.M008201200 . PMID   11136725.
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

Further reading

• Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (Pt 2): 471–81. doi:10.1042/bj3360471. PMC   1219893 . PMID   9820826.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi: 10.1074/jbc.M008201200 . PMID   11136725.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Morel AP, Sentis S, Bianchin C, Le Romancer M, Jonard L, Rostan MC, Rimokh R, Corbo L (2003). "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms". J. Cell Sci. 116 (Pt 14): 2929–36. doi: 10.1242/jcs.00480 . PMID   12771185.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C (2007). "Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation". Infect. Immun. 75 (3): 1484–92. doi:10.1128/IAI.01315-06. PMC   1828547 . PMID   17178784.

External links

• Human CNOT8 genome location and CNOT8 gene details page in the UCSC Genome Browser .