CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene. [5]
CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene. [5]
The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis. [6]
DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene.
E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.
Cyclin-dependent kinases regulatory subunit 1 is a protein that in humans is encoded by the CKS1B gene.
Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.
COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene. It encodes a subunit of the COP9 signalosome.
COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.
CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4-Not deadenylase complex.
TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.
CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene. It is a subunit of the CCR4-Not deadenylase complex.
Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.
CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene. It is a subunit of the CCR4-Not deadenylase complex.
CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.
CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene. It is a subunit of the CCR4-Not deadenylase complex.
CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.
General transcription factor IIE subunit 2 (GTF2E2), also known as transcription initiation factor IIE subunit beta (TFIIE-beta), is a protein that in humans is encoded by the GTF2E2 gene.
CCR4-NOT transcription complex subunit 10 is a protein that in humans is encoded by the CNOT10 gene. It is a subunit of the CCR4-Not deadenylase complex.
CCR4-NOT transcription complex subunit 9 is a protein that in humans is encoded by the CNOT9 gene.
CCR4-NOT transcription complex subunit 11 is a protein that in humans is encoded by the CNOT11 gene. It is a subunit of the CCR4-Not deadenylase complex.
CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene. It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.
Carbon Catabolite Repression—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3′-5′ exonuclease and a ubiquitin ligase. The exonuclease activity of CCR4-Not shortens the poly(A) tail found at 3' end of almost every eukaryotic mRNA. The complex is present both in the nucleus where it regulates transcription and in the cytoplasm where it associates with translating ribosomes and RNA processing bodies. In mammalian cell, it has a function in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair in nucleus. Ccr4–Not complex plays an important role in mRNA decay and protein quality control in the cytoplasm.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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