COX7A2

COX7A2
Identifiers
Aliases	COX7A2 , COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL, cytochrome c oxidase subunit 7A2
External IDs	OMIM: 123996; MGI: 1316715; HomoloGene: 36082; GeneCards: COX7A2; OMA:COX7A2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q14.1 Start 75,237,675 bp [1] End 75,250,323 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 E1|9 43.82 cM Start 79,662,643 bp [2] End 79,667,160 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell left testis right testis pancreatic ductal cell right ventricle Brodmann area 23 sperm apex of heart primary visual cortex lateral nuclear group of thalamus Top expressed in facial motor nucleus medial ganglionic eminence digastric muscle otic placode temporal muscle sternocleidomastoid muscle epithelium of stomach triceps brachii muscle intercostal muscle medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function electron transfer activity cytochrome-c oxidase activity Cellular component mitochondrial inner membrane membrane mitochondrion mitochondrial respirasome Biological process proton transmembrane transport electron transport chain regulation of oxidative phosphorylation mitochondrial respirasome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1347 12866 Ensembl ENSG00000112695 ENSMUSG00000032330 UniProt P14406 P48771 RefSeq (mRNA) NM_001865 NM_009945 RefSeq (protein) NP_001856 NP_001353221 NP_001353222 NP_034075 Location (UCSC) Chr 6: 75.24 – 75.25 Mb Chr 9: 79.66 – 79.67 Mb PubMed search [3] [4]
Wikidata
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Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene. ^{[5] [6] [7]}

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.

This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues.

In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112695 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032330 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene. 119 (2): 299–305. doi:10.1016/0378-1119(92)90287-Y. PMID   1327965.
6. Merante F, Duncan AM, Mitchell G, Duff C, Rommens J, Robinson BH (Aug 1997). "Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene". Genome. 40 (3): 318–24. doi:10.1139/g97-044. PMID   9202412.
7. "Entrez Gene: COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)".

External links

• Human COX7A2 genome location and COX7A2 gene details page in the UCSC Genome Browser .

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural Organization and Transcription Regulation of Nuclear Genes Encoding the Mammalian Cytochrome c Oxidase Complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–44. doi: 10.1016/S0079-6603(08)60830-2 . ISBN   978-0-12-540061-9. PMID   9752724.
• Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart". Eur. J. Biochem. 203 (1–2): 193–9. doi:10.1111/j.1432-1033.1992.tb19847.x. PMID   1309697.
• Fabrizi GM, Rizzuto R, Nakase H, et al. (1989). "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase". Nucleic Acids Res. 17 (17): 7107. doi:10.1093/nar/17.17.7107. PMC   318441 . PMID   2550906.
• Taanman JW, Hall RE, Tang C, et al. (1993). "Tissue distribution of cytochrome c oxidase isoforms in mammals. Characterization with monoclonal and polyclonal antibodies". Biochim. Biophys. Acta. 1225 (1): 95–100. doi:10.1016/0925-4439(93)90128-n. PMID   8241294.
• Merante F, Ling M, Duncan AM, et al. (1997). "Cloning, characterization, and chromosomal localization of human liver form cytochrome c oxidase subunit VIa related genes". Genome. 40 (3): 325–31. doi:10.1139/g97-045. PMID   9202413.
• Hüttemann M, Mühlenbein N, Schmidt TR, et al. (2000). "Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene". Biochim. Biophys. Acta. 1492 (1): 252–8. doi:10.1016/s0167-4781(00)00087-7. PMID   11004498.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.