CPA4 (gene)

Last updated
CPA4
Protein CPA4 PDB 2bo9.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CPA4 , CPA3, carboxypeptidase A4
External IDs OMIM: 607635 MGI: 1919041 HomoloGene: 56753 GeneCards: CPA4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016352
NM_001163446

NM_027926

RefSeq (protein)

NP_001156918
NP_057436

NP_082202

Location (UCSC)n/a Chr 6: 30.57 – 30.59 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene. [4] [5] [6]

Contents

This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [6]

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In molecular biology, MEST intronic transcript 1, antisense RNA, also known as MESTIT1 or PEG1-AS is a long non-coding RNA. It is an imprinted gene, which is paternally expressed. In humans, it is found on chromosome 7q32, imprinted genes on chromosome 7 are believed to be involved in Russell-Silver syndrome (RSS). However, it is believed that MESTIT1 is unlikely to cause Russell-Silver syndrome as there is a lack of mutations in this gene in Russell-Silver syndrome patients. MESTIT1 may regulate the expression of the MEST gene.

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039070 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI (Jul 1999). "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells". Cancer Res. 59 (12): 2981–8. PMID   10383164.
  5. Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID   10860668.
  6. 1 2 "Entrez Gene: CPA4 carboxypeptidase A4".

Further reading