CPSF2

Last updated
PDB-6V4X. CPSF2 protein highlighted within the CPSF complex. CPSF2 is rainbow colored. Other subunits of the complex are represented by solid colors. CPSF2 highlighted within CPSF complex.png
PDB-6V4X. CPSF2 protein highlighted within the CPSF complex. CPSF2 is rainbow colored. Other subunits of the complex are represented by solid colors.
CPSF2
Identifiers
Aliases CPSF2 , CPSF100, cleavage and polyadenylation specific factor 2
External IDs OMIM: 606028 MGI: 1861601 HomoloGene: 6460 GeneCards: CPSF2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017437
NM_001322270
NM_001322271
NM_001322272

NM_016856

RefSeq (protein)

NP_001309199
NP_001309200
NP_001309201
NP_059133

NP_058552

Location (UCSC) Chr 14: 92.12 – 92.17 Mb Chr 12: 101.94 – 101.97 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene. [5] [6] [7] This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation. [8] The CPSF2 protein connects the two subunits of the complex, mCF and mPSF. [8] Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function. [9] This protein has been identified as an essential subunit of the complex as certain mutations in the region inhibit CPSF complex formation. [9]

Contents

Related Research Articles

Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature mRNA for translation. In many bacteria, the poly(A) tail promotes degradation of the mRNA. It, therefore, forms part of the larger process of gene expression.

<span class="mw-page-title-main">TATA-binding protein</span> Protein-coding gene in the species Homo sapiens

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

<span class="mw-page-title-main">Post-transcriptional modification</span> RNA processing within a biological cell

Transcriptional modification or co-transcriptional modification is a set of biological processes common to most eukaryotic cells by which an RNA primary transcript is chemically altered following transcription from a gene to produce a mature, functional RNA molecule that can then leave the nucleus and perform any of a variety of different functions in the cell. There are many types of post-transcriptional modifications achieved through a diverse class of molecular mechanisms.

Cleavage and polyadenylation specificity factor (CPSF) is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (pre-mRNA) molecule in the process of gene transcription. In eukaryotes, messenger RNA precursors (pre-mRNA) are transcribed in the nucleus from DNA by the enzyme, RNA polymerase II. The pre-mRNA must undergo post-transcriptional modifications, forming mature RNA (mRNA), before they can be transported into the cytoplasm for translation into proteins. The post-transcriptional modifications are: the addition of a 5' m7G cap, splicing of intronic sequences, and 3' cleavage and polyadenylation.

<span class="mw-page-title-main">Eukaryotic transcription</span> Transcription is heterocatalytic function of DNA

Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary RNA replica. Gene transcription occurs in both eukaryotic and prokaryotic cells. Unlike prokaryotic RNA polymerase that initiates the transcription of all different types of RNA, RNA polymerase in eukaryotes comes in three variations, each translating a different type of gene. A eukaryotic cell has a nucleus that separates the processes of transcription and translation. Eukaryotic transcription occurs within the nucleus where DNA is packaged into nucleosomes and higher order chromatin structures. The complexity of the eukaryotic genome necessitates a great variety and complexity of gene expression control.

<span class="mw-page-title-main">SF3A1</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

<span class="mw-page-title-main">HNRPF</span> Protein-coding gene in the species Homo sapiens

Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the HNRNPF gene.

<span class="mw-page-title-main">CSTF2</span> Protein-coding gene in humans

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.

<span class="mw-page-title-main">NUDT21</span> Protein-coding gene in the species Homo sapiens

Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an enzyme that in humans is encoded by the NUDT21 gene. It belongs to the Nudix family of hydrolases.

<span class="mw-page-title-main">CPSF1</span> Protein-coding gene in humans

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.

<span class="mw-page-title-main">PAPOLA</span> Protein-coding gene in the species Homo sapiens

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.

<span class="mw-page-title-main">CSTF1</span> Protein-coding gene in the species Homo sapiens

Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.

<span class="mw-page-title-main">CSTF3</span> Protein-coding gene in the species Homo sapiens

Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.

<span class="mw-page-title-main">CSTF2T</span> Protein-coding gene in the species Homo sapiens

Cleavage stimulation factor 64 kDa subunit, tau variant is a protein that in humans is encoded by the CSTF2T gene.

<span class="mw-page-title-main">CPSF3</span> Protein-coding gene in humans

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.

<span class="mw-page-title-main">CPSF4</span> Protein-coding gene in humans

Cleavage and polyadenylation specificity factor subunit 4 is a protein that in humans is encoded by the CPSF4 gene.

<span class="mw-page-title-main">CPSF6</span> Protein-coding gene in humans

Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.

<span class="mw-page-title-main">INTS11</span> Protein-coding gene in the species Homo sapiens

Integrator complex subunit 11 is a protein that in humans is encoded by the CPSF3L gene.

<span class="mw-page-title-main">PAPOLG</span> Protein-coding gene in the species Homo sapiens

Poly(A) polymerase gamma is an enzyme that in humans is encoded by the PAPOLG gene.

<span class="mw-page-title-main">CPSF7</span> Protein-coding gene in humans

Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165934 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041781 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jenny A, Hauri HP, Keller W (Dec 1994). "Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit". Mol Cell Biol. 14 (12): 8183–90. doi:10.1128/MCB.14.12.8183. PMC   359357 . PMID   7969155.
  6. Samiotaki M, Balatsos NA, Courtis N, Tsiapalis CM (Jan 2001). "Assignment of the 100-kDa subunit of cleavage and polyadenylation specificity factor (CPSF2) to human chromosome 14q31.3 by radiation hybrid mapping". Cytogenet Cell Genet. 90 (3–4): 328–9. doi:10.1159/000056798. PMID   11124543. S2CID   84335742.
  7. "Entrez Gene: CPSF2 cleavage and polyadenylation specific factor 2, 100kDa".
  8. 1 2 "Human Gene CPSF2 (ENST00000298875.9) from GENCODE V43". genome.ucsc.edu. Retrieved 2023-03-05.
  9. 1 2 Zhang Y, Sun Y, Shi Y, Walz T, Tong L (2020-02-20). "Structural Insights into the Human Pre-mRNA 3′-End Processing Machinery". Molecular Cell. 77 (4): 800–809.e6. doi:10.1016/j.molcel.2019.11.005. ISSN   1097-2765. PMC   7036032 . PMID   31810758.

Further reading