CST5

For the TC LID CST5, see Sable Island § Sable Island station.

CST5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RN7, 1ROA
Identifiers
Aliases	CST5 , cystatin D
External IDs	OMIM: 123858; MGI: 1930004; HomoloGene: 55615; GeneCards: CST5; OMA:CST5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p11.21 Start 23,875,934 bp [1] End 23,879,748 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 G3 Start 149,246,977 bp [2] End 149,252,213 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland right adrenal cortex olfactory zone of nasal mucosa upper lobe of left lung left adrenal gland left adrenal cortex right lung tonsil body of pancreas muscle tissue Top expressed in parotid gland lacrimal gland submandibular gland masseter muscle lymph node sexually immature organism grey matter prosencephalon cerebrum cerebral hemisphere More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding cysteine-type endopeptidase inhibitor activity protease binding Cellular component extracellular region extracellular exosome extracellular space Biological process negative regulation of peptidase activity negative regulation of cysteine-type endopeptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1473 58214 Ensembl ENSG00000170367 ENSMUSG00000033156 UniProt P28325 Q9JM84 RefSeq (mRNA) NM_001900 NM_021405 RefSeq (protein) NP_001891 NP_067380 Location (UCSC) Chr 20: 23.88 – 23.88 Mb Chr 2: 149.25 – 149.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cystatin-D is a protein that in humans is encoded by the CST5 gene. ^{[5] [6]}

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000170367 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033156 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Freije JP, Abrahamson M, Olafsson I, Velasco G, Grubb A, Lopez-Otin C (Dec 1991). "Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor". J Biol Chem. 266 (30): 20538–43. doi: 10.1016/S0021-9258(18)54958-9 . PMID   1939105.
6. "Entrez Gene: CST5 cystatin D".

External links

• The MEROPS online database for peptidases and their inhibitors: I25.005
• Human CST5 genome location and CST5 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : P28325 (Cystatin-D) at the PDBe-KB .

Further reading

• Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. doi:10.1002/pro.5560060102. PMC   2143511 . PMID   9007972.
• Saitoh E, Isemura S, Sanada K, et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID   3202964.
• Dickinson DP, Thiesse M, Dempsey LD, Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. 4 (3–4): 573–80. doi:10.1177/10454411930040034401. PMID   7690606.
• Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics. 24 (1): 172–5. doi:10.1006/geno.1994.1595. PMID   7896273.
• Balbín M, Hall A, Grubb A, et al. (1994). "Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases". J. Biol. Chem. 269 (37): 23156–62. doi: 10.1016/S0021-9258(17)31633-2 . PMID   8083219.
• Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. doi:10.1089/dna.1994.13.97. PMID   8179826.
• Freije JP, Balbín M, Abrahamson M, et al. (1993). "Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva". J. Biol. Chem. 268 (21): 15737–44. doi: 10.1016/S0021-9258(18)82317-1 . PMID   8340398.
• Freije JP, Pendás AM, Velasco G, et al. (1993). "Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization". Cytogenet. Cell Genet. 62 (1): 29–31. doi:10.1159/000133438. PMID   8422752.
• Balbín M, Freije JP, Abrahamson M, et al. (1993). "A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level". Hum. Genet. 90 (6): 668–9. doi:10.1007/BF00202491. PMID   8444475. S2CID   23090315.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Dickinson DP, Thiesse M, Hicks MJ (2002). "Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland". DNA Cell Biol. 21 (1): 47–65. doi:10.1089/10445490252810311. PMID   11879580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Alvarez-Fernandez M, Liang YH, Abrahamson M, Su XD (2005). "Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile" (PDF). J. Biol. Chem. 280 (18): 18221–8. doi: 10.1074/jbc.M411914200 . PMID   15728581. S2CID   12151927.