CST5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CST5 , cystatin D | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 123858 MGI: 1930004 HomoloGene: 55615 GeneCards: CST5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Cystatin-D is a protein that in humans is encoded by the CST5 gene. [5] [6]
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [6]
Cathepsin O is an enzyme that in humans is encoded by the CTSO gene.
The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below.
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. The protein is a cysteine cathepsin, a lysosomal cysteine protease that plays a major role in intracellular protein catabolism.
Cystatin-A is a protein that in humans is encoded by the CSTA gene.
Cystatin-B is a protein that in humans is encoded by the CSTB gene.
Cathepsin H is a protein that in humans is encoded by the CTSH gene.
Cystatin-S is a protein that in humans is encoded by the CST4 gene.
Cystatin-SN is a protein that in humans is encoded by the CST1 gene.
Cystatin-SA is a protein that in humans is encoded by the CST2 gene.
Cystatin-M is a protein that in humans is encoded by the CST6 gene.
Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 is an enzyme that in humans is encoded by the MMP17 gene.
Cystatin-F is a protein that in humans is encoded by the CST7 gene.
Cathepsin L2,, is a protein encoded in humans by the CTSV gene.
Cystatin-8 is a protein that in humans is encoded by the CST8 gene.
Cathepsin W is a protein that in humans is encoded by the CTSW gene.
Cathepsin F is a protein that in humans is encoded by the CTSF gene.
Cystatin-9-like is a protein that in humans is encoded by the CST9L gene.
Cystatin-11 is a protein that in humans is encoded by the CST11 gene.
Fetuin-B is a protein that in humans is encoded by the FETUB gene.
Cystatin-like 1 is a protein that in humans is encoded by the CSTL1 gene.