CTDP1

CTDP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J2X, 1ONV, 2K7L
Identifiers
Aliases	CTDP1 , CCFDN, FCP1, CTD phosphatase subunit 1
External IDs	OMIM: 604927 MGI: 1926953 HomoloGene: 31254 GeneCards: CTDP1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	79,754,503 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	80,512,910 bp
RNA expression pattern
	Top expressed in
	oocyte; ; blood; ; skin of abdomen; ; secondary oocyte; ; monocyte; ; sural nerve; ; spleen; ; right lobe of liver; ; body of stomach; ; popliteal artery;
	Top expressed in
	spermatid; ; hair follicle; ; seminiferous tubule; ; primitive streak; ; somite; ; Paneth cell; ; bone marrow; ; ascending aorta; ; yolk sac; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II CTD heptapeptide repeat phosphatase activity ; protein binding ; hydrolase activity ; phosphoprotein phosphatase activity ; TFIIF-class transcription factor complex binding ; Tat protein binding ;
Cellular component	cytoplasm ; centrosome ; spindle pole ; RNA polymerase II, holoenzyme ; spindle ; microtubule organizing center ; midbody ; spindle midzone ; cytoskeleton ; nucleus ; nucleoplasm ; intracellular membrane-bounded organelle ; protein-containing complex ; actin cytoskeleton ; nuclear speck ;
Biological process	transcription elongation from RNA polymerase II promoter ; protein dephosphorylation ; exit from mitosis ; transcription by RNA polymerase II ; cell division ; negative regulation of cell growth involved in cardiac muscle cell development ; dephosphorylation of RNA polymerase II C-terminal domain ; cell cycle ; positive regulation by host of viral transcription ; positive regulation of viral transcription ;
	Sources:Amigo / QuickGO
Orthologs
	9150
	67655
	ENSG00000282752 ; ENSG00000060069
	ENSMUSG00000033323
	Q9Y5B0
	Q7TSG2
	NM_001202504 ; NM_004715 ; NM_048368 ; NM_001318511
	NM_026295
	NP_001189433 ; NP_001305440 ; NP_004706 ; NP_430255
	NP_080571
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 15, 2023

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.^[5]^[6]^[7]

This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.^[7]

Interactions

CTDP1 has been shown to interact with WD repeat-containing protein 77,^[8] GTF2F1 ^[6] and POLR2A.^[9]

Related Research Articles

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans.

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.

DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the POLR2B gene.

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.

DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.

DNA-directed RNA polymerase II subunit RPB4 is an enzyme that in humans is encoded by the POLR2D gene.

DNA-directed RNA polymerase II subunit RPB9 is an enzyme that in humans is encoded by the POLR2I gene.

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.

Elongin A is a protein that in humans is encoded by the ELOA gene.

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.

General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.

mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene.

CTD small phosphatase-like protein is an enzyme that in humans is encoded by the CTDSPL gene.

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.

Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is 70 kDa cleavage product of the hepatitis C virus polyprotein. It acts as a serine protease. C-terminal two-thirds of the protein also acts as helicase and nucleoside triphosphatase. First (N-terminal) 180 aminoacids of NS3 has additional role as cofactor domains for NS2 protein.

References

1 2 3 ENSG00000060069 GRCh38: Ensembl release 89: ENSG00000282752, ENSG00000060069 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033323 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J (Feb 1998). "An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 94 (26): 14300–5. Bibcode:1997PNAS...9414300A. doi: 10.1073/pnas.94.26.14300 . PMC 24951 . PMID 9405607.
1 2 Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (Nov 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J Biol Chem. 273 (42): 27593–601. doi: 10.1074/jbc.273.42.27593 . PMID 9765293.
1 2 "Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1".
↑ Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. England. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217 . PMID 12560496.
↑ Scully, R; Anderson S F; Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605 . ISSN 0027-8424. PMC 20825 . PMID 9159119.

External links

Human CTDP1 genome location and CTDP1 gene details page in the UCSC Genome Browser .

Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605 . PMC 20825 . PMID 9159119.
Marshall NF, Dahmus GK, Dahmus ME (1998). "Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat protein". J. Biol. Chem. 273 (48): 31726–30. doi: 10.1074/jbc.273.48.31726 . PMID 9822634.
Cho H, Kim TK, Mancebo H, et al. (1999). "A protein phosphatase functions to recycle RNA polymerase II". Genes Dev. 13 (12): 1540–52. doi:10.1101/gad.13.12.1540. PMC 316795 . PMID 10385623.
Angelicheva D, Turnev I, Dye D, et al. (1999). "Congenital cataracts facial dysmorphism neuropathy (CCFDN) syndrome: a novel developmental disorder in Gypsies maps to 18qter". Eur. J. Hum. Genet. 7 (5): 560–6. doi: 10.1038/sj.ejhg.5200319 . PMID 10439962.
Marshall NF, Dahmus ME (2000). "C-terminal domain phosphatase sensitivity of RNA polymerase II in early elongation complexes on the HIV-1 and adenovirus 2 major late templates". J. Biol. Chem. 275 (42): 32430–7. doi: 10.1074/jbc.M005898200 . PMID 10938286.
Licciardo P, Napolitano G, Majello B, Lania L (2001). "Inhibition of Tat transactivation by the RNA polymerase II CTD-phosphatase FCP1". AIDS. 15 (3): 301–7. doi: 10.1097/00002030-200102160-00002 . PMID 11273209. S2CID 33054695.
Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat". Virology. 296 (1): 6–16. doi: 10.1006/viro.2002.1438 . PMID 12036313.
Washington K, Ammosova T, Beullens M, et al. (2002). "Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II". J. Biol. Chem. 277 (43): 40442–8. doi: 10.1074/jbc.M205687200 . PMID 12185079.
Mandal SS, Cho H, Kim S, et al. (2002). "FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation". Mol. Cell. Biol. 22 (21): 7543–52. doi:10.1128/MCB.22.21.7543-7552.2002. PMC 135672 . PMID 12370301.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Licciardo P, Amente S, Ruggiero L, et al. (2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217 . PMID 12560496.
Nguyen BD, Chen HT, Kobor MS, et al. (2003). "Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB". Biochemistry. 42 (6): 1460–9. doi:10.1021/bi0265473. PMID 12578358.
Friedl EM, Lane WS, Erdjument-Bromage H, et al. (2003). "The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2328–33. Bibcode:2003PNAS..100.2328F. doi: 10.1073/pnas.2628049100 . PMC 151340 . PMID 12591939.
Kamada K, Roeder RG, Burley SK (2003). "Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2296–9. Bibcode:2003PNAS..100.2296K. doi: 10.1073/pnas.262798199 . PMC 151334 . PMID 12591941.
Nguyen BD, Abbott KL, Potempa K, et al. (2003). "NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 5688–93. Bibcode:2003PNAS..100.5688N. doi: 10.1073/pnas.1031524100 . PMC 156262 . PMID 12732728.
Varon R, Gooding R, Steglich C, et al. (2003). "Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome". Nat. Genet. 35 (2): 185–9. doi:10.1038/ng1243. PMID 14517542. S2CID 22461437.
Yu X, Chini CC, He M, et al. (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–42. Bibcode:2003Sci...302..639Y. doi:10.1126/science.1088753. PMID 14576433. S2CID 29407635.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000060069 GRCh38: Ensembl release 89: ENSG00000282752, ENSG00000060069 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033323 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9405607-5] Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J (Feb 1998). "An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 94 (26): 14300–5. Bibcode:1997PNAS...9414300A. doi: 10.1073/pnas.94.26.14300 . PMC 24951 . PMID 9405607.

[pmid9765293-6] 1 2 Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (Nov 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J Biol Chem. 273 (42): 27593–601. doi: 10.1074/jbc.273.42.27593 . PMID 9765293.

[entrez-7] 1 2 "Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1".

[pmid12560496-8] Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. England. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217 . PMID 12560496.

[pmid9159119-9] Scully, R; Anderson S F; Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605 . ISSN 0027-8424. PMC 20825 . PMID 9159119.

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CTDP1

Contents

Interactions

Related Research Articles

References

External links

Further reading