WD repeat-containing protein 77

WDR77
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GQB, 4X60, 4X61, 4X63, 5EMJ, 5EML, 5EMM, 5FA5, 5EMK, 5C9Z
Identifiers
Aliases	WDR77 , MEP-50, MEP50, Nbla10071, p44, p44/Mep50, HKMT1069, WD repeat domain 77
External IDs	OMIM: 611734 MGI: 1917715 HomoloGene: 11466 GeneCards: WDR77
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.2 Start 111,439,890 bp [1] End 111,449,256 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 105,866,685 bp [2] End 105,877,353 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube gastrocnemius muscle body of stomach left ventricle left adrenal gland rectum left uterine tube minor salivary gland body of pancreas stromal cell of endometrium Top expressed in primitive streak somite abdominal wall endocardial cushion atrium maxillary prominence renal corpuscle morula myocardium of ventricle ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyl-CpG binding protein binding nuclear receptor coactivator activity protein-arginine N-methyltransferase activity Cellular component cytoplasm cytosol Golgi apparatus methylosome nucleoplasm nucleus Biological process regulation of transcription by RNA polymerase II secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development negative regulation of epithelial cell proliferation involved in prostate gland development positive regulation of cell population proliferation negative regulation of cell population proliferation peptidyl-arginine N-methylation positive regulation of nucleic acid-templated transcription spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79084 70465 Ensembl ENSG00000116455 ENSMUSG00000000561 UniProt Q9BQA1 Q99J09 RefSeq (mRNA) NM_024102 NM_001317062 NM_001317063 NM_001317064 NM_027432 RefSeq (protein) NP_001303991 NP_001303992 NP_001303993 NP_077007 NP_081708 Location (UCSC) Chr 1: 111.44 – 111.45 Mb Chr 3: 105.87 – 105.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene. ^{[5] [6] [7]}

Interactions

WD repeat-containing protein 77 has been shown to interact with CTDP1 ^[8] and Protein arginine methyltransferase 5. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000116455 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000561 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J Biol Chem. 277 (10): 8243–7. doi: 10.1074/jbc.M109984200 . PMID   11756452.
6. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
7. "Entrez Gene: WDR77 WD repeat domain 77".
8. Licciardo P, Amente Stefano, Ruggiero Luca, Monti Maria, Pucci Piero, Lania Luigi, Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. England. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC   149217 . PMID   12560496.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Licciardo P, Amente S, Ruggiero L, et al. (2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC   149217 . PMID   12560496.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID   15221005. S2CID   3114318.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi: 10.1016/j.febslet.2004.12.045 . PMID   15670829.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Furuno K, Masatsugu T, Sonoda M, et al. (2006). "Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro". Biochem. Biophys. Res. Commun. 345 (3): 1051–8. doi:10.1016/j.bbrc.2006.05.014. PMID   16712789.
• Zhou L, Wu H, Lee P, Wang Z (2007). "Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells". J. Mol. Endocrinol. 37 (2): 283–300. doi: 10.1677/jme.1.02062 . PMID   17032745.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Liang JJ, Wang Z, Chiriboga L, et al. (2007). "The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors". J. Urol. 177 (5): 1918–22. doi:10.1016/j.juro.2007.01.017. PMID   17437848.

• Rengasamy, M, Zhang, F, Vashisht, A, Song, WM, et al. (2017). "The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer". Nucleic Acids Res. 45 (19): 11106–11120. doi: 10.1093/nar/gkx727 . PMC   5737218 . PMID   28977470.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9BQA1 (Methylosome protein 50) at the PDBe-KB .